HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Michael Grimm Georg Wieselthaler Ernst Wolner Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Grimm, M. Articles by Laufer, G. Search for Related Content PubMed PubMed Citation Articles by Grimm, M. Articles by Laufer, G.

Ann Thorac Surg 1995;59:916-920
© 1995 The Society of Thoracic Surgeons

ICD Therapy in Survivors of Sudden Cardiac Death Awaiting Heart Transplantation

Departments of Cardiothoracic Surgery and Internal Medicine, and Institute of Medical Computer Science, University of Vienna, Vienna, Austria

Accepted for publication December 21, 1994.

The impact of implantable cardioverter defibrillator (ICD) therapy on survival of heart transplant candidates is of major socioeconomic and ethical interest. However, efficacy is even uncertain for patients at highest risk of tachyarrhythmic death on the waiting list. We studied 60 selected heart transplant candidates (mean age, 55.8 years; mean left ventricular ejection fraction, 0.15; functional class III and IV) with a history of successful resuscitation by external electric defibrillation for spontaneous, syncopal ventricular tachyarrhythmia during the study period from March 1992 through September 1994. At the time of registration for transplantation, 30 patients had ICD devices implanted, whereas 30 patients lacked ICD therapy for various nonmedical reasons. Both therapy groups were comparable in clinical and hemodynamic characteristics as well as in intention to transplant (median waiting time to transplantation, 5.7 and 6 months, respectively; not significant by log-rank method). Survival on the waiting list was significantly improved by ICD therapy; only 1 of the 30 ICD patients (19 transplanted) but 7 of the 30 non-ICD patients (14 transplanted) died on the waiting list (p < 0.05 by log-rank method). Implantable cardioverter defibrillator therapy did not affect survival after transplantation as compared with non-ICD patients (not significant by log-rank method). During the waiting time, 26 of the ICD patients (87%) experienced adequate ICD discharges, and 12 of the non-ICD patients were treated successfully by external electric defibrillation (40%). During the waiting time, there was a clear trend toward prolonged hospitalization of ICD patients (median, 23 days; range, 0 to 102 days) as compared with the non-ICD patients (median, 13 days; range, 0 to 62 days); however, it was not statistically significant. Implantable cardioverter defibrillator therapy significantly improves survival on the waiting list in heart transplant candidates with a history of external electric defibrillation for syncopal ventricular tachyarrhythmia. Despite an obviously short waiting time, registration of these high-risk patients without ICD therapy for cost-saving reasons is ethically questionable.

This article has been cited by other articles:

				F Duru, R Candinas, M Lachat, M Rahn, G Noll, T.F Luscher, and M Turina Electrical and mechanical support in advanced heart failure. Rationale and feasibility of a combined management strategy Eur. Heart J., July 1, 2002; 23(13): 1005 - 1010. [Full Text] [PDF]