HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Janet R. Maurer Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Kesten, S. Articles by Maurer, J. R. Search for Related Content PubMed PubMed Citation Articles by Kesten, S. Articles by Maurer, J. R.

Ann Thorac Surg 1995;59:877-879
© 1995 The Society of Thoracic Surgeons

Aprotinin Reduces Blood Loss in Lung Transplant Recipients

The Toronto Lung Transplant Program, The Toronto Hospital, University of Toronto, Toronto, Ontario, Canada

Accepted for publication January 4, 1995.

After early experience with perioperative bleeding in sequential single-lung transplant recipients, aprotinin was introduced in an attempt to reduce this complication and the attendant morbidity. Records of sequential single-lung transplantations (n = 33) performed between January 1989 and November 1991 were reviewed to assess the impact of aprotinin on perioperative blood loss and blood product requirements. Recipients were divided according to whether or not they required cardiopulmonary bypass. In patients requiring cardiopulmonary bypass (n = 15), mean estimated postoperative blood loss was 3,000 +/- 500 mL in those who did not receive aprotinin (n = 4) compared with 1,177 +/- 253 mL in those who received aprotinin (n = 11) (p < 0.05). An average of 8.0 +/- 0.7 units of packed red blood cells were administered to patients not receiving aprotinin compared with 3.1 +/- 0.7 units to those who received aprotinin (p < 0.05). Requirements for fresh frozen plasma were similar in each group. There were no differences in blood loss or blood product replacement in the group not undergoing cardiopulmonary bypass (n = 18). Therefore, we conclude that aprotinin decreases postoperative blood loss and blood product requirements in patients undergoing sequential single-lung transplantation under cardiopulmonary bypass.

This article has been cited by other articles:

				K. R. Balsara, S. T. Morozowich, S. S. Lin, R. D. Davis, B. G. Phillips-Bute, M. Hartwig, J. Z. Appel, and I. J. Welsby Aprotinin's effect on blood product transfusion in off-pump bilateral lung transplantation Interactive CardioVascular and Thoracic Surgery, January 1, 2009; 8(1): 45 - 48. [Abstract] [Full Text] [PDF]

				W. Beierlein, A. M. Scheule, W. Dietrich, and G. Ziemer Forty Years of Clinical Aprotinin Use: A Review of 124 Hypersensitivity Reactions Ann. Thorac. Surg., February 1, 2005; 79(2): 741 - 748. [Abstract] [Full Text] [PDF]

				A. M. Mahdy and N. R. Webster Perioperative systemic haemostatic agents Br. J. Anaesth., December 1, 2004; 93(6): 842 - 858. [Abstract] [Full Text] [PDF]

				T. Kyriss, H. Wurst, G. Friedel, R. Jaki, and H. Toomes Reduced blood loss by aprotinin in thoracic surgical operations associated with high risk of bleeding. : A placebo-controlled, randomized phase IV study Eur. J. Cardiothorac. Surg., July 1, 2001; 20(1): 38 - 41. [Abstract] [Full Text] [PDF]

				R. F. Roberts, G. P. Nishanian, J. N. Carey, S. H. Darbinian, J. D. Kim, Y. Sakamaki, J. Y. Chang, V. A. Starnes, and M. L. Barr Addition of aprotinin to organ preservation solutions decreases lung reperfusion injury Ann. Thorac. Surg., July 1, 1998; 66(1): 225 - 230. [Abstract] [Full Text] [PDF]

				T. L. Spray Use of Aprotinin in Pediatric Organ Transplantation Ann. Thorac. Surg., June 1, 1998; 65(90060): S71 - 73. [Abstract] [Full Text] [PDF]

				C. C Hlozek, N. G Smedira, T. J Kirby, A. N Patel, and M. Perl Cardiopulmonary bypass (CPB) for lung transplantation Perfusion, March 1, 1997; 12(2): 107 - 112. [Abstract] [PDF]

				Y. J. Gu, J. de Haan, U. P. M. Brenken, W. J. de Boer, Jm. Prop, W. van Oeveren, and G. L. T. Group CLOTTING AND FIBRINOLYTIC DISTURBANCE DURING LUNG TRANSPLANTATION: EFFECT OF LOW-DOSE APROTININ J. Thorac. Cardiovasc. Surg., September 1, 1996; 112(3): 599 - 606. [Abstract] [Full Text]