| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Ann Thorac Surg 1995;59:336-341
© 1995 The Society of Thoracic Surgeons
Department of Surgery II, Okayama University Medical School, Okayama, Japan
Accepted for publication September 13, 1994.
A canine bilateral single-lung transplantation model was used to evaluate 21-hour lung preservation with low-potassium dextran glucose solution. Donor lungs were flushed with low-potassium dextran glucose solution (50 mL/kg), inflated with 100% oxygen (35 mL/kg), and preserved at 8°C. Bilateral single-lung transplantation was performed without using cardiopulmonary bypass. The ischemic times to the right and left lungs were designed to be 3 and 6 hours, respectively, in group 1 (n = 5) and 18 and 21 hours in group 2 (n = 6). After bilateral single-lung transplantation, animals were maintained on a ventilator for 12 hours and lung function, including arterial blood gas and pulmonary hemodynamics, was measured. All 5 dogs in group 1 and 5 of 6 dogs in group 2 completed bilateral single-lung transplantation successfully and survived for 12 hours with excellent lung function. Arterial oxygen tension and mean pulmonary artery pressure were stable during the 12-hour assessment period in both groups and did not differ significantly from donor values. Twelve hours after reperfusion, mean arterial oxygen tension (inspired oxygen fraction = 1.0) was 590 ± 18 mm Hg in group 1 and 604 ± 8 mm Hg in group 2. After the 12-hour assessment period, the animals were extubated and immunosuppressed. Two dogs in group 2 survived for 7 and 8 days, respectively, with a mean arterial oxygen tension of 74 mm Hg on room air at 5 days. These results lead us to conclude that lungs flushed with low-potassium dextran glucose solution, inflated with 100% oxygen, and preserved at 8°C for 21 hours provides excellent lung function in a canine bilateral single-lung transplantation model in which the animal is totally dependent on the function of transplanted lung tissue.
This article has been cited by other articles:
|
|
 |
|
  T. M. Aziz, T. M. Pillay, P. A. Corris, J. Forty, C. J. Hilton, A. Hasan, and J. H. Dark Perfadex for clinical lung procurement: is it an advance? Ann. Thorac. Surg., March 1, 2003; 75(3): 990 - 995. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. de Perrot, M. Liu, T. K. Waddell, and S. Keshavjee Ischemia-Reperfusion-induced Lung Injury Am. J. Respir. Crit. Care Med., February 15, 2003; 167(4): 490 - 511. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. I. Gasparri, N. C.P. Jannis, W. J. Flameng, T. E. Lerut, and D. E.M. Van Raemdonck Ischemic preconditioning enhances donor lung preservation in the rabbit Eur. J. Cardiothorac. Surg., December 1, 1999; 16(6): 639 - 646. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. L. Featherstone, F. J. Kelly, M. J. Shattock, D. J. Hearse, and D. J. Chambers Hypothermic preservation of isolated rat lungs in modified bicarbonate buffer, EuroCollins solution or St Thomas' Hospital cardioplegic solution Eur. J. Cardiothorac. Surg., November 1, 1999; 14(5): 508 - 515. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. A. R. Binns, N. F. DeLima, S. A. Buchanan, J. T. Cope, R. C. King, C. A. Marek, K. S. Shockey, C. G. Tribble, and I. L. Kron BOTH BLOOD AND CRYSTALLOID-BASED EXTRACELLULAR SOLUTIONS ARE SUPERIOR TO INTRACELLULAR SOLUTIONS FOR LUNG PRESERVATION J. Thorac. Cardiovasc. Surg., December 1, 1996; 112(6): 1515 - 1521. [Abstract] [Full Text]
|
|
|
|
|
|
N. F. DeLima, O. A. R. Binns, S. A. Buchanan, J. T. Cope, M. C. Mauney, K. S. Shockey, C. G. Tribble, and I. L. Kron Low-Potassium Solution for Lung Preservation in the Setting of High-Flow Reperfusion Ann. Thorac. Surg., March 1, 1996; 61(3): 973 - 976. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| ANN THORAC SURG | ASIAN CARDIOVASC THORAC ANN | EUR J CARDIOTHORAC SURG |
| J THORAC CARDIOVASC SURG | ICVTS | ALL CTSNet JOURNALS |
