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Ann Thorac Surg 1994;58:1764-1766
© 1994 The Society of Thoracic Surgeons
The New York Hospital-Cornell University Medical College, New York, New York USA
Accepted for publication April 12, 1994.
* Address reprint requests to Dr Rosengart, The New York Hospital, 525 E 68th St. New York, NY 10021.
Heparin-induced thrombocytopenia and thrombosis syndrome was diagnosed in a 63-year-old woman 11 days after coronary artery bypass grafting. Her only presenting complaints were incisional leg pain and vague chest discomfort. The syndrome was suspected when her platelet count was found to be 37,000/µL. A subsequent ventilation-perfusion lung scan showed findings highly probable for pulmonary embolism. An inferior venacavogram obtained before a pulmonary angiogram revealed a large retrohepatic thrombus at the right atrial junction. The patient was successfully treated with the defibrinogenating agent ancrod (Arvin). A diagnosis of heparin-induced thrombocytopenia and thrombosis syndrome should be considered and heparin therapy should be avoided in patients with low platelet counts who have been previously treated with heparin.
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