ATS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 QUICK SEARCH:   [advanced]


     


This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Simon R. Knight
Mary S. Pohl
Joel D. Cooper
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Trachiotis, G. D.
Right arrow Articles by Trulock, E. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Trachiotis, G. D.
Right arrow Articles by Trulock, E. P.

Ann Thorac Surg 1994;58:1718-1720
© 1994 The Society of Thoracic Surgeons


Articles

Tidal volume and respiratory rate changes during CO2 rebreathing after lung transplantation

Gregery D. Trachiotis, MDa,b, Simon R. Knight, MDa,b, Mary S. Pohl, BSNa,b, G.Alexander Patterson, MDa,b, Joel D. Cooper, MDa,b, Elbert P. Trulock, MD*,a,b

a Washington University Lung Transplant Group, Division of Cardiothoracic Surgery, Department of Surgery, Barnes Hospital, Washington University School of Medicine, St. Louis, Missouri USA
b Washington University Lung Transplant Group, Division of Respiratory and Critical Care, Department of Medicine, Barnes Hospital, Washington University School of Medicine, St. Louis, Missouri USA

Accepted for publication June 6, 1994.

* Address reprint requests to Dr Trulock, Division of Critical Care and Pulmonary Medicine, Barnes Hospital, Campus Box 8052, 660 S Euclid Ave, St. Louis, MO 63110-1093.

To evaluate the contribution of the respiratory pattern to the ventilatory response after lung transplantation, we studied the changes in minute ventilation, tidal volume, and respiratory rate during CO2 rebreathing in 14 patients with severe obstructive pulmonary disease, and compared them with 10 normal subjects. Seven patients underwent a bilateral lung transplantation and 7 patients had single-lung transplantation. Single-lung transplant recipients increased their respiratory rate by the last postoperative test compared with either preoperative or initial test periods (0.38 ± 0.13 versus 0.027 ± 0.24 or 0.12 ± 0.08 breaths · min–1 · mm Hg–1; P < 0.005). Bilateral lung transplant recipients showed a diminished ability to augment their respiratory rate by the last postoperative test compared with either preoperative or initial test periods (0.13 ± 0.23 versus 0.54 ± 0.25 or 0.25 ± 0.29 breaths · min–1 · mm Hg–1; p < 0.06). The restored ventilatory response by the fourth postoperative week was due to a statistically significant increase in tidal volume for both single and bilateral lung transplant recipients. This study demonstrates that when lung transplant recipients have an appropriate ventilatory response to CO2 rebreathing, single-lung transplant recipients have a respiratory pattern similar to normal; whereas the bilateral lung transplant recipients show the effects of total pulmonary denervation. We conclude that the preserved ventilatory response in lung transplant recipients is composed of a respiratory pattern that is influenced by the presence or absence of vagal inputs.







HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 1994 by The Society of Thoracic Surgeons.