HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Fukushima, N. Articles by Matsuda, H. Search for Related Content PubMed PubMed Citation Articles by Fukushima, N. Articles by Matsuda, H.

The Annals of Thoracic Surgery, Vol 58, 1651-1656, Copyright © 1994 by The Society of Thoracic Surgeons

ARTICLES

Study of efficacies of leukocyte-depleted terminal blood cardioplegia in 24-hour preserved hearts

N Fukushima, R Shirakura, S Nakata, M Kaneko, S Miyagawa, Y Naka, JC Chang, G Matsumiya, S Nakano and H Matsuda
First Department of Surgery, Osaka University Medical School, Japan.

To evaluate the effect of leukocyte-depleted terminal blood cardioplegia on prolonged preservation, 41 canine hearts were stored in modified Collins' solution and transplanted heterotopically. Hearts were transplanted soon after harvesting in group 1 and after 24-hour preservation in groups 2, 3, and 4. Blood cardioplegia was applied just before aortic unclamping in groups 3 and 4; group 3 received simple blood cardioplegia and group 4 received leukocyte-depleted cardioplegia. The percentage of the preload recruitable stroke work and diastolic compliance after transplantation compared with the preharvesting value in group 4 did not differ from those in group 1, but the percentage of the preload recruitable stroke work in groups 2 and 3 was significantly lower than that in groups 1 and 4. The percentage of diastolic compliance in groups 2 and 3 was significantly higher than that in groups 1 and 4. Coronary blood flow 40 minutes after aortic unclamping in group 4 did not differ from that in group 1, but was significantly higher than the blood flows in groups 2 and 3. Significant production of malondialdehyde was detected during terminal blood cardioplegia and 10 minutes after aortic unclamping in groups 2 and 3, but never in groups 1 and 4. After leukocyte-depleted terminal cardioplegia, the myocardial adenosine triphosphate content increased to the preharvesting value in group 4. Our results suggest that leukocyte-depleted terminal blood cardioplegia may be effective in replenishing the energy-depleted myocardium and reducing reperfusion injury, resulting in adequate cardiac function.

This article has been cited by other articles:

				T. Higuchi, K. Yamauchi-Takihara, G. Matsumiya, N. Fukushima, H. Ichikawa, T. Kuratani, Y. Maehata, and Y. Sawa Granulocyte Colony-Stimulating Factor Prevents Reperfusion Injury After Heart Preservation Ann. Thorac. Surg., April 1, 2008; 85(4): 1367 - 1373. [Abstract] [Full Text] [PDF]

				J. Martin, M. Krause, C. Benk, G. Lutter, M. Siegenthaler, and F. Beyersdorf Blood cardioplegia filtration Perfusion, January 1, 2003; 18(1_suppl): 75 - 80. [Abstract] [PDF]

				T. Sakaguchi, Y. Sawa, N. Fukushima, M. Nishimura, H. Ichikawa, Y. Kaneda, and H. Matsuda A novel strategy of decoy transfection against nuclear factor-{{kappa}}B in myocardial preservation Ann. Thorac. Surg., February 1, 2001; 71(2): 624 - 629. [Abstract] [Full Text] [PDF]

				H. Kishima, S.-i. Takeda, S. Miyoshi, A. Matsumura, M. Minami, T. Utsumi, K.-i. Omori, K. Nakahara, and H. Matsuda Microvascular Permeability of the Non-Heart-Beating Rabbit Lung After Warm Ischemia and Reperfusion: Role of Neutrophil Elastase Ann. Thorac. Surg., April 1, 1998; 65(4): 913 - 918. [Abstract] [Full Text] [PDF]