HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Bradley L. Bufkin Richard J. Mellitt Robert A. Guyton Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Huang, A. H. Articles by Guyton, R. A. Search for Related Content PubMed PubMed Citation Articles by Huang, A. H. Articles by Guyton, R. A.

Ann Thorac Surg 1994;58:1499-1504
© 1994 The Society of Thoracic Surgeons

---

Articles

Coronary sinus pressure and arterial venting do not affect retrograde cardioplegia distribution

Carlyle Fraser Heart Center, Crawford Long Hospital of Emory University, Atlanta, Georgia USA

Accepted for publication May 12, 1994.

^_* Address reprint requests to Dr Guyton, Carlyle Fraser Heart Center, Crawford Long Hospital of Emory University, Suite 4356, 550 Peachtree St NE, Atlanta, GA 30365-2225.

Retrograde techniques for the administration of cardioplegia solutions are of interest because of their relative practical convenience, and because of the possibility that they provide better delivery to myocardial regions jeopardized by coronary stenosis than can be achieved with traditional antegrade techniques. This study was designed to test the following three hypotheses about how the distribution of cardioplegia by retrograde techniques might be optimized: (1) venting an occluded coronary artery improves the distribution of cardioplegia to the myocardial region originally supplied by it; (2) increasing the coronary sinus perfusion pressure makes the distribution of cardioplegia through the myocardium more uniform; and (3) increasing the driving pressure, as achieved by increasing the coronary sinus perfusion pressure or occluding a left coronary artery, improves the distribution of flow to the right ventricular free wall and interventricular septum. Tracer microspheres infused retrogradely with cardioplegia solution into canine hearts in vitro showed that the distribution of flow through the coronary sinus is consistently and significantly nonuniform, and is not significantly altered by coronary arterial occlusion and venting, or by increases in coronary sinus perfusion pressure.

This article has been cited by other articles:

				S. F. Mironov, F. J. Vetter, and A. M. Pertsov Fluorescence imaging of cardiac propagation: spectral properties and filtering of optical action potentials Am J Physiol Heart Circ Physiol, July 1, 2006; 291(1): H327 - H335. [Abstract] [Full Text] [PDF]

				A. Matiukas, B. G. Mitrea, A. M. Pertsov, J. P. Wuskell, M.-d. Wei, J. Watras, A. C. Millard, and L. M. Loew New near-infrared optical probes of cardiac electrical activity Am J Physiol Heart Circ Physiol, June 1, 2006; 290(6): H2633 - H2643. [Abstract] [Full Text] [PDF]

				C. W. Zemlin, S. Mironov, and A. M. Pertsov Near-threshold field stimulation: Intramural versus surface activation Cardiovasc Res, January 1, 2006; 69(1): 98 - 106. [Abstract] [Full Text] [PDF]

				A. V. Zaitsev, O. Berenfeld, S. F. Mironov, J. Jalife, and A. M. Pertsov Distribution of Excitation Frequencies on the Epicardial and Endocardial Surfaces of Fibrillating Ventricular Wall of the Sheep Heart Circ. Res., March 3, 2000; 86(4): 408 - 417. [Abstract] [Full Text] [PDF]

				I. B. Krukenkamp and S. Levitsky Myocardial Protection: Modern Studies Ann. Thorac. Surg., May 1, 1996; 61(5): 1581 - 1582. [Full Text]

				X. Y. Jin, D. G. Gibson, and J. R. Pepper Early Changes in Regional and Global Left Ventricular Function After Aortic Valve Replacement : Comparison of Crystalloid, Cold Blood, and Warm Blood Cardioplegias Circulation, November 1, 1995; 92(9): 155 - 162. [Abstract] [Full Text]