HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Mehrdad M.R. Amirhamzeh Henry M. Spotnitz Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Amirhamzeh, M. M. R. Articles by Spotnitz, H. M. Search for Related Content PubMed PubMed Citation Articles by Amirhamzeh, M. M. R. Articles by Spotnitz, H. M.

Ann Thorac Surg 1994;58:1374-1379
© 1994 The Society of Thoracic Surgeons

---

Articles

Systolic arterial pressure recovery after ventricular fibrillation in pigs

Department of Surgery, Columbia University College of Physicians & Surgeons, New York, New York USA

Accepted for publication March 30, 1994.

^_* Address reprint requests to Dr Spotnitz, Department of Surgery, Columbia University P&S 14-460, 630 W 168th St, New York, NY 10032.

Ventricular fibrillation (VF) is induced during implantable cardioverter defibrillator insertion and can result in cardiovascular collapse. The relation between repeated VF trials of varying duration and systolic blood pressure (SBP) recovery rate was studied in 6 pigs. Two implantable cardioverter defibrillator patches were placed on the heart, and VF was varied in a cyclic pattern until cardiovascular collapse occurred. A negative logarithmic relation between SBP recovery rate and duration of VF was found in 4 of the pigs with correlation coefficients of 0.62 to 0.97 (p < 0.05). The overall correlation coefficient was 0.51 for all 116 data points (p < 0.001). Although there was a significant (p < 0.05) decrease in average (± standard error of the mean) baseline SBP in the second half of each experiment (83 ± 5 mm Hg versus 77 ± 6 mm Hg), no significant difference in SBP was observed during VF (17 ± 1 mm Hg versus 16 ± 1 mm Hg) or after 15 seconds of SBP recovery (51 ± 4 mm Hg versus 46 ± 3 mm Hg) between the two halves of the experiments. Cardiovascular collapse occurred without warning; epinephrine was effective in reversing it. In conclusion, SBP recovery rate and duration of VF have a negative logarithmic relation consistent with a negative effect on left ventricular contractility with prolongation of VF. The onset of cardiovascular collapse during implantable cardioverter defibrillator testing cannot be predicted on the basis of monitored blood pressure alone.

This article has been cited by other articles:

				G. P. Walcott, S. B. Melnick, C. R. Killingsworth, W. M. Smith, and R. E. Ideker Effects of burst stimulation during ventricular fibrillation on cardiac function after defibrillation Am J Physiol Heart Circ Physiol, July 11, 2003; 285(2): H766 - H774. [Abstract] [Full Text] [PDF]

				D. G. Rabkin, S. E. Cabreriza, J. C. LaCorte, A. D. Weinberg, L. Coku, R. Walsh, R. Mosca, and H. M. Spotnitz Sodium-hydrogen exchange inhibition preserves ventricular function after ventricular fibrillation in the intact swine heart J. Thorac. Cardiovasc. Surg., June 1, 2003; 125(6): 1499 - 1509. [Abstract] [Full Text] [PDF]