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Gary M. Kline
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Verdi J. DiSesa
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Ann Thorac Surg 1994;58:1316-1318
© 1994 The Society of Thoracic Surgeons

Articles

Tolerance to experimental cardiac allografts produced by neonatal intrathymic injection of donor cells

Gary M. Kline, MD, Zhenya Shen, MD, Muhammad Mohiuddin, MD, Susan Rostami, BS, Verdi J. DiSesa, MD*

Division of Cardiothoracic Surgery, Medical College of Pennsylvania, and Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania USA

* Address reprint requests to Dr DiSesa, Division of Cardiothoracic Surgery, Medical College of Pennsylvania, 3300 Henry Ave, Philadelphia, PA 19129.

Intrathymic inoculation of allogeneic cells after systemic administration of antilymphocyte serum in adult experimental animals has produced donor-specific tolerance to cardiac allografts. We investigated whether thymic injection of allogeneic cells without antilymphocyte serum in neonatal Lewis rats (day 1 of life) with immature immune systems also produced tolerance to cardiac grafts. Intrathymic or intraperitoneal injection of 5 x 107 Lewis (control) or Lewis-Brown Norway (allogeneic) spleen cells in Lewis neonates was followed by heterotopic cardiac transplantation using Lewis, Lewis-Brown Norway, or Wistar Furth (third-party allograft) hearts at 6 to 8 weeks of age. Graft survival was prolonged with both intraperitoneal and intrathymic allogeneic cells. Recipt ents of cells by the intrathymic route had longer graft survival, and 2 of 5 animals achieved permanent graft acceptance (longer than 100 days). As expected, Lewis isografts survived indefinitely, whereas third-party Wistar Furth allografts were rejected in the usual time frame. Intrathymic introduction of allogeneic cells in a neonatal recipient with an immature immune system can produce donor-specific tolerance to a subsequent graft without the need for a systemic immunosuppression regimen, even transiently.




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D. Y. Wu and I. Goldschneider
Tolerance to Cyclosporin A-Induced Autologous Graft-Versus-Host Disease Is Mediated by a CD4+CD25+ Subset of Recent Thymic Emigrants
J. Immunol., June 15, 2001; 166(12): 7158 - 7164.
[Abstract] [Full Text] [PDF]


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