ATS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Andrew S. Wechsler
John C. Entwistle, III
Thomas Yeh, Jr
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wechsler, A. S.
Right arrow Articles by Jakoi, E. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wechsler, A. S.
Right arrow Articles by Jakoi, E. R.

Ann Thorac Surg 1994;58:1282-1284
© 1994 The Society of Thoracic Surgeons

Articles

Early gene changes in myocardial ischemia

Andrew S. Wechsler, MD*, John C. Entwistle, III, MD, Thomas Yeh, Jr, MD, Mai Ding, MD, Emma R. Jakoi, PhD

Division of Cardiothoracic Surgery, Department of Surgery, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia, USA

* Address reprint requests to Dr Wechsler, Division of Cardiothoracic Surgery, Box 980645, MCV Station, Richmond, VA 23298-0645.

After certain periods of myocardial ischemia and reperfusion, cardiac dysfunction exists in the absence of myonecrosis. In a blood-perfused isolated rat heart model, we have demonstrated early gene changes that are associated with global myocardial "stuunning." Early gene changes included elevations in the expression of messenger RNAs for HSP70, c-myc and c-fos. Increased expression of messenger RNAs for protooncogenes is an important observation because of the role of protooncogenes as nuclear transcription factors. From these study findings, it would appear that the stunning state is associated with early gene changes that may signal the induction of a hypertrophic process. Subsequent studies are required to demonstrate the exact events which take place in the course of stunning that directly initiate an alteration in gene expression.




This article has been cited by other articles:


Home page
 Eur J Cardiothorac SurgHome page
J. P. Schmitt, H. Schunkert, D. E. Birnbaum, and H. Aebert
Kinetics of heat shock protein 70 synthesis in the human heart after cold cardioplegic arrest
Eur J Cardiothorac Surg, September 1, 2002; 22(3): 415 - 420.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
T. Yeh Jr, A. S. Wechsler, L. J. Graham, K. E. Loesser, D. A. Sica, L. Wolfe, and E. R. Jakoi
Acute Brain Death Alters Left Ventricular Myocardial Gene Expression
J. Thorac. Cardiovasc. Surg., February 1, 1999; 117(2): 365 - 374.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
H. Aebert, T. Cornelius, T. Ehr, S. R. Holmer, D. E. Birnbaum, G. A. J. Riegger, and H. Schunkert
Expression of Immediate Early Genes After Cardioplegic Arrest and Reperfusion
Ann. Thorac. Surg., June 1, 1997; 63(6): 1669 - 1675.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 1994 by The Society of Thoracic Surgeons.