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Ann Thorac Surg 1994;58:1240-1246
© 1994 The Society of Thoracic Surgeons

Articles

Importance of elevated plasma homocysteine levels as a risk factor for atherosclerosis

Philippe A. Masser, MD, Lloyd M. Taylor, Jr, MD, John M. Porter, MD*

Division of Vascular Surgery, Oregon Health Sciences University, Portland, Oregon, USA

* Address reprint requests to Dr Porter, Division of Vascular Surgery, OP-11, Oregon Health Sciences University, 3181 SW Sam Jackson Park Rd, Portland, OR 97201-3098.

Atherosclerosis is a leading cause of death and disability in the Western world, and an important risk factor for it may be an elevated level of the plasma amino acid homocysteine. The biochemical characteristics of homocysteine, along with historical, laboratory, and clinical evidence for its pathologic role in atherosclerosis, are reviewed. Possible therapies for reducing elevated homocysteine levels and the possible impact of therapy in atherosclerosis are examined.




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