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The Annals of Thoracic Surgery, Vol 58, 1240-1246, Copyright © 1994 by The Society of Thoracic Surgeons
PA Masser, LM Taylor Jr and JM Porter
Atherosclerosis is a leading cause of death and disability in the Western
world, and an important risk factor for it may be an elevated level of the
plasma amino acid homocysteine. The biochemical characteristics of
homocysteine, along with historical, laboratory, and clinical evidence for
its pathologic role in atherosclerosis, are reviewed. Possible therapies
for reducing elevated homocysteine levels and the possible impact of
therapy in atherosclerosis are examined.
ARTICLES
Importance of elevated plasma homocysteine levels as a risk factor for atherosclerosis
Division of Vascular Surgery, Oregon Health Sciences University, Portland 97201-3098.
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