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Ann Thorac Surg 1994;58:1161-1163
© 1994 The Society of Thoracic Surgeons

Articles

Carcinoid heart disease: Early failure of an allograft valve replacement

Sunil K. Ohri, FRCS*,a,b,c, John B. Schofield, MRCPatha,b,c, Humphrey Hodgson, FRCPa,b,c, Celia M. Oakley, FRCPa,b,c, Bruce E. Keogh, FRCSa,b,c

a Cardiothoracic Unit, Department of Surgery, Department of PathologyHammersmith Hospital, Royal Postgraduate Medical School, London, England
b Gastroenterology Unit, Department of MedicineHammersmith Hospital, Royal Postgraduate Medical School, London, England
c Cardiology Unit, Department of Medicine, Hammersmith Hospital, Royal Postgraduate Medical School, London, England

Accepted for publication January 17, 1994.

* Address reprint requests to Mr Ohri, Cardiothoracic Unit, Department of Surgery, Hammersmith Hospital, Royal Postgraduate Medical School, Du Cane Rd, London W12 OHS, England.

A woman who had carcinoid syndrome and carcinoid heart disease underwent tricuspid and pulmonary valve replacements with a xenograft and a cryopreserved allograft, respectively. Within 3 months of the operation severe pulmonary regurgitation and pulmonary hypertension refractory to medical therapy developed. Autopsy found the biomechanical tricuspid valve to be free of disease but the allograft in the pulmonary position was involved by carcinoid heart disease in a fashion similar to the excised native pulmonary valve.




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