ATS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Marko I. Turina
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tönz, M.
Right arrow Articles by Turina, M. I.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tönz, M.
Right arrow Articles by Turina, M. I.

Ann Thorac Surg 1994;58:1031-1035
© 1994 The Society of Thoracic Surgeons

Articles

Treatment of acute pulmonary hypertension with inhaled nitric oxide

Martin Tönz, MD*,a,b, Ludwig K. von Segesser, MDa,b, Julian Schilling, MDa,b, Thomas F. Lüscher, MDa,b, Georg Noll, MDa,b, Boris Leskosek, BAa,b, Marko I. Turina, MDa,b

a Clinic for Cardiovascular Surgery, University Hospital, Zurich, Switzerland
b Division of Cardiology, University Hospital, Bern, Switzerland

Accepted for publication March 19, 1994.

* Address reprint requests to Dr Tönz, Clink for Pediatric Surgery, University Hospital, 3010 Bern, Switzerland.

We examined the effectiveness of inhaled nitric oxide (NO) as a selective pulmonary vasodilator in acute pulmonary hypertension in an in vivo canine model with fixed cardiac output. In 5 dogs, total right heart bypass was instituted, and pulmonary hypertension was induced by infusion of the thromboxane analogue U-46619. During U-46619 infusion, NO was administered at 10 and 40 ppm for 5 minutes followed by breathing of the oxygen mixture without NO. Pump flow was held constant during the experiment. Infusion of the thromboxane analogue resulted in an increase in pulmonary vascular resistance and systemic vascular resistance from 147 ± 83 to 740 ± 126 dyne · s · cm–5 and from 1,720 ± 113 to 2,407 ± 232 dyne · s · cm–5, respectively. During inhalation of 10 ppm NO, pulmonary vascular resistance significantly decreased to 613 ± 55 dyne · s · cm–5 (p < 0.05) and further decreased to 527 ± 163 dyne · s · cm–5 with 40 ppm NO inhalation (p < 0.05). Systemic vascular resistance did not change during NO treatment (2,300 ± 70 dyne · s · cm–5 during 40 ppm NO). There was no increase in intrapulmonary shunting or methemoglobin levels during NO inhalation. In this setting, with a constant cardiac output throughout the experiment, NO acted as a selective pulmonary vasodilator without altering systemic vascular resistance. However, induced pulmonary vasoconstriction was only partially reversed by NO inhalation.




This article has been cited by other articles:


Home page
 PerfusionHome page
F. Urdaneta, E. Lobato, T. Beaver, J. Muehlschlegel, D. Kirby, C. Klodell, and A. Sidi
RETRACTED: Treating pulmonary hypertension post cardiopulmonary bypass in pigs: milrinone vs. sildenafil analog
Perfusion, March 1, 2008; 23(2): 117 - 125.
[Abstract] [PDF]

Home page
 Br J AnaesthHome page
E. B. Lobato, T. Beaver, J. Muehlschlegel, D. S. Kirby, C. Klodell, and A. Sidi
Treatment with phosphodiesterase inhibitors type III and V: milrinone and sildenafil is an effective combination during thromboxane-induced acute pulmonary hypertension
Br. J. Anaesth., March 1, 2006; 96(3): 317 - 322.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
F. Urdaneta, J. L. Willert, T. Beaver, B. Naik, D. S. Kirby, and E. B. Lobato
Effects of a New Phosphodiesterase Enzyme Type V Inhibitor (UK 343-664) Versus Milrinone in a Porcine Model of Acute Pulmonary Hypertension
Ann. Thorac. Surg., October 1, 2004; 78(4): 1433 - 1437.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
M. R. Bonnell, F. Urdaneta, D. S. Kirby, N. R. Valdez, T. M. Beaver, and E. B. Lobato
Effects of sildenafil analogue UK 343-664 on a porcine model of acute pulmonary hypertension
Ann. Thorac. Surg., January 1, 2004; 77(1): 238 - 242.
[Abstract] [Full Text] [PDF]

Home page
 Eur J Cardiothorac SurgHome page
A. F. Corno, P. Tozzi, C. Y. Genton, and L. K. von Segesser
Surgically induced unilateral pulmonary hypertension: time-related analysis of a new experimental model
Eur J Cardiothorac Surg, April 1, 2003; 23(4): 513 - 517.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
L. K. von Segesser
Cardiopulmonary support and extracorporeal membrane oxygenation for cardiac assist
Ann. Thorac. Surg., August 1, 1999; 68(2): 672 - 677.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
M. Tonz, O. N. Krogmann, O. M. Hess, B. Leskosek, T. Mihaljevic, L. K. von Segesser, and M. I. Turina
Effect of Intermittent Warm Blood Cardioplegia on Functional Recovery After Prolonged Cardiac Arrest
Ann. Thorac. Surg., October 1, 1996; 62(4): 1146 - 1151.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 1994 by The Society of Thoracic Surgeons.