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Ann Thorac Surg 1994;58:833-835
© 1994 The Society of Thoracic Surgeons

Articles

Use of glutaraldehyde solution in the treatment of acute aortic dissections

Ying-Fu Chen, MD*, Shah-Hwa Chou, MD, Chaw-Chi Chiu, MD, Young-Tso Lin, MD, Huey-Ji Wang, MD

Departments of Surgery and Pathology, Kaohsiung Medica College, Kaohsiung, Taiwan

Accepted for publication January 19, 1994.

* Address reprint requests to Dr Chen, Division of Cardiovascular Surgery, Kaohsiung Medical College, 100 Shih-Chuan 1st Rd, Kaohsiung, Taiwan.

We report on a promising method for toughening and strengthening the fragile aortic wall that involves the direct application of a 25% glutaraldehyde solution and that has proved to be both technically simple and safe. The operation was successfully employed in 5 patients with acute aortic dissections, 3 with a Stanford type A and 2 with a type B dissection. Histologic examination of the glutaraldehyde-treated portions of the aortic wall showed no detectable difference between them and the sections of untreated aortic wall. All patients survived the operation. The duration of follow-up ranged from 9 to 31 months (mean, 14.0 months). All 5 patients were in good condition at the time of the last follow-up. The preliminary results indicate that the use of a 25% glutaraldehyde solution to strengthen the aortic wall during operations for the repair of acute aortic dissections, regardless of whether they are type A or type B, may reduce the incidence of catastrophic perioperative bleeding and promote favorable results.




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New Technique for Repair of Ascending Thoracic Aortic Dissections
Ann. Thorac. Surg., January 1, 1997; 63(1): 287 - 287.
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