HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Stig Steen Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Kimblad, P. O. Articles by Steen, S. Search for Related Content PubMed PubMed Citation Articles by Kimblad, P. O. Articles by Steen, S.

Ann Thorac Surg 1994;58:728-733
© 1994 The Society of Thoracic Surgeons

---

Articles

Eliminating the strong pulmonary vasoconstriction caused by euro-collins solution

Department of Cardiothoracic Surgery, University Hospital, Lund, Sweden

Accepted for publication November 23, 1993.

^_* Address reprint requests to Dr Steen, Department of Cardiothoracic Surgery, University Hospital, S-221 85 Lund, Sweden.

Single-flush perfusion with Euro-Collins solution (ECS), after pretreatment with prostaglandin E₁ or prostacyclin, is at most centers the standard procedure for preservation of lungs for transplantation. In a previous study, we showed that the high potassium content of ECS causes strong pulmonary Vasoconstriction at temperatures higher than 20°C. In the present study, five drugs used as pretreatment and added to the perfusate were compared for their ability to counteract ECS-induced constriction of porcine pulmonary arteries; papaverine reduced the vasoconstrictive effect by 92% ± 4%; nifedipine, by 62% ± 6%; the thromboxane A₂ receptor antagonist daltroban, by 15% ± 4%; and prostaglandin E₁, by 12% ± 4%. On the other hand, prostacyclin not only failed to reduce ECS-induced Vasoconstriction but at the highest concentration tested, enhanced it by 37% ± 7%. The combination of papaverine (10^–4 mol/L) and nifedipine (10^–6.5 mol/L) was the only pretreatment to abolish ECS-induced vasoconstriction; moreover, it had no adverse effect on endothelial function. Neither prostaglandin E₁ nor prostacyclin effectively counteracts ECS-induced Vasoconstriction, though they may have other beneficial effects.

This article has been cited by other articles:

				W. Zou, Q. Yang, A. P. C. Yim, and G.-W. He Impaired endothelium-derived hyperpolarizing factor-mediated relaxation in porcine pulmonary microarteries after cold storage with Euro-Collins and University of Wisconsin solutions J. Thorac. Cardiovasc. Surg., July 1, 2003; 126(1): 208 - 215. [Abstract] [Full Text] [PDF]

				T. M. Aziz, T. M. Pillay, P. A. Corris, J. Forty, C. J. Hilton, A. Hasan, and J. H. Dark Perfadex for clinical lung procurement: is it an advance? Ann. Thorac. Surg., March 1, 2003; 75(3): 990 - 995. [Abstract] [Full Text] [PDF]

				S. Fischer, D. Hopkinson, M. Liu, and S. Keshavjee RAFFINOSE IMPROVES THE FUNCTION OF RAT PULMONARY GRAFTS STORED FOR TWENTY-FOUR HOURS IN LOW-POTASSIUM DEXTRAN SOLUTION J. Thorac. Cardiovasc. Surg., March 1, 2000; 119(3): 488 - 492. [Abstract] [Full Text] [PDF]

				M. S. Bhabra, D. N. Hopkinson, T. E. Shaw, and T. L. Hooper Relative Importance of Prostaglandin/Cyclic Adenosine Monophosphate and Nitric Oxide/Cyclic Guanosine Monophosphate Pathways in Lung Preservation Ann. Thorac. Surg., November 1, 1996; 62(5): 1494 - 1499. [Abstract] [Full Text]

				G. Wu, F. Zhang, R. K. Salley, M. C. Robinson, and S. Chien A Systematic Study of Hypothermic Lung Preservation Solutions: Euro-Collins Solution Ann. Thorac. Surg., August 1, 1996; 62(2): 356 - 362. [Abstract] [Full Text]

				N. F. DeLima, O. A. R. Binns, S. A. Buchanan, M. C. Mauney, J. T. Cope, K. S. Shockey, C. G. Tribble, and I. L. Kron EURO-COLLINS SOLUTION EXACERBATES LUNG INJURY IN THE SETTING OF HIGH-FLOW REPERFUSION J. Thorac. Cardiovasc. Surg., July 1, 1996; 112(1): 111 - 116. [Abstract] [Full Text]

				R. Ingemansson, G. Massa, R. K. Pandita, T. Sjoberg, and S. Steen Perfadex is superior to euro-collins solution regarding 24-hour preservation of vascular function Ann. Thorac. Surg., November 1, 1995; 60(5): 1210 - 1214. [Abstract] [PDF]