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The Annals of Thoracic Surgery, Vol 58, 698-703, Copyright © 1994 by The Society of Thoracic Surgeons
WJ Scott, JL Schwabe, NC Gupta, NA Dewan, SD Reeb and JT Sugimoto
Positron emission tomography detects increased glucose uptake in malignant
tissue using the glucose analogue [2-18F]fluoro-2-deoxy-D- glucose. We
reviewed the scans obtained in 62 patients with lung tumors. All had
undergone computed tomography and had tissue-based diagnoses: 22 had
adenocarcinomas, 12 had squamous cell carcinomas, 13 had other
malignancies, 1 had organizing pneumonia, 1 had a hamartoma, and 13 had
granulomas. Positron emission tomography with [2-18F]fluoro-
2-deoxy-D-glucose identified 44 of 47 malignancies. Two of three false-
negative findings were tumors that were 1 cm2 or less and the other was a
bronchioloalveolar carcinoma. All three false-positive findings were
granulomas. The sensitivity and specificity of the technique were 93.6% and
80%, respectively, and the positive and negative predictive values were
93.6% and 80%, respectively. The differential uptake ratio was determined
in all 62 patients. The mean differential uptake ratio (+/- the standard
error of the mean) for malignant tumors was 6.4 +/- 0.56 and that for
benign tumors was 1.14 +/- 0.26 (p < 0.0001, t test). Twenty-five of the
patients had N2 lymph nodes evaluated pathologically. Positron emission
tomography with [2-18F]fluoro-2-deoxy- D-glucose identified negative N2
nodes in 19 of 22 patients (86%) with negative nodes and positive N2 nodes
in 2 of 3 patients (66%) with positive nodes, including one instance missed
by computed tomography.(ABSTRACT TRUNCATED AT 250 WORDS)
ARTICLES
Positron emission tomography of lung tumors and mediastinal lymph nodes using [18F]fluorodeoxyglucose. The Members of the PET-Lung Tumor Study Group
Department of Surgery, Creighton University Medical Center, Omaha, Nebraska 68131.
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