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Tomislav Mihaljevic
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Ann Thorac Surg 1994;58:677-684
© 1994 The Society of Thoracic Surgeons

Articles

Superior late patency of small-diameter dacron grafts seeded with omental microvascular cells: An experimental study

Miralem Pasic, MD, PhD*, Werner Müller-Glauser, PhD, Ludwig K. Von Segesser, MD, Mario Lachat, MD, Tomislav Mihaljevic, MD, Marko I. Turina, MD

Clinic for Cardiovascular Surgery, Department of Surgery, University Hospital Zurich, Zurich Switzerland

* Address reprint requests to Dr Pasic, Clinic for Cardiovascular Surgery, Department of Surgery, University Hospital Zurich, Rämistrasse 100, CH-8091 Zurich, Switzerland.

The purpose of the study was to investigate the effect of omental microvascular cell seeding on the patency of small-diameter Dacron prostheses usable for coronary artery bypass grafting. In a canine carotid artery model, each dog (n = 64) received one seeded and one similar nonseeded Dacron prosthesis (internal diameter = 4 or 6 mm). Enzymatically harvested omental microvascular cells (omentum = 27.6 ± 5.9 g [± the standard deviation]; range, 17 to 50 g) were seeded prior to implantation. The seeding density was 1.91 ± 0.26 [± the standard error) x 106 cells/cm2 of graft surface. Dipyridamole (75 mg/d) and acetylsalicylic acid (325 mg/d) were administered orally for 4 weeks postoperatively. The prostheses were explanted between 2 and 52 weeks after placement. The results were assessed by angiography; light, scanning electron, and transmission electron microscopy; and morphometry. The seeded grafts developed a uniform luminal monolayer of endothelial cells with minimal platelet or cellular deposition. These grafts also had a significantly higher overall patency rate and significantly larger thrombus-free surface areas than the nonseeded grafts. The overall actuarial patency rates at 1 week, 5, 12, 26, and 52 weeks were 100%, 98%, 93%, 93%, and 93%, respectively, for seeded Dacron grafts and 100%, 91%, 61%, 54%, and 18%, respectively, for nonseeded grafts. The patency rates of Dacron grafts usable for coronary artery bypass grafting are significantly improved by seeding with omental microvascular cells in a canine model.




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