HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Motoi Aoe Gregory D. Trachiotis Kan Okabayashi Joel D. Cooper Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Aoe, M. Articles by Patterson, G. A. Search for Related Content PubMed PubMed Citation Articles by Aoe, M. Articles by Patterson, G. A.

Ann Thorac Surg 1994;58:655-661
© 1994 The Society of Thoracic Surgeons

---

Articles

Administration of prostaglandin E₁ after lung transplantation improves early graft function

Division of Carcliothoracic Surgery, Department of Surgery, and Department of Pharmacology, Washington University School of Medicine, Barnes Hosoital, St. Louis, Missouri USA

^_* Address reprint requests to Dr Patterson, Division of Cardiothoracic Surgery, Washington University School of Medicine, Suite 3108, Queeny Tower, One Barnes Hospital Plaza, St. Louis, MO 63110.

Early graft dysfunction continues to be a major clinical problem after lung transplantation. The objective of this experiment was to determine whether continuous administration of prostaglandin E₁, (PGE₁) after lung transplantation has a beneficial effect on early graft function. Left lung allotransplantation was performed in 10 sizematched mongrel dogs (weight, 24.4 to 31.4 kg). Lung preservation consisted of a bolus injection of PGE₁ (250 µg) into the pulmonary artery, followed by a pulmonary artery flush with 50 mL/kg of 4 °C modified Euro-Collins solution. The lungs were then stored at 1 °C for 12 hours. Left lung transplantation was performed using standard technique. The right pulmonary artery and right bronchus were ligated prior to chest closure. Animals were placed in the supine position and ventilated for 6 hours with 100% oxygen at a rate of 20 breaths/min, a tidal volume of 550 mL, and a positive end-expiratory pressure of 5 cm H₂O. Animals were randomly allocated to one of two groups. Group I animals (n = 6) received continuous PGE₁ infusion from the onset of implaniation. The dose was gradually increased and fixed when mean systemic pressure showed a 10% decrease (mean PGE₁, dose, 31.7 ± 6.9 ng · kg^-1 · min^-1). Group II animals (n = 4) received no PGE₁ After the 6-hour assessment period, arterial oxygen tension and alveolar-arterial oxygen pressure difference were preserved in group I compared with group II (group I versus group II: arterial oxygen tension, 255.8 ± 37.6 mm Hg versus 64.7 ± 7.9 mm Hg [p < 0.05]; alveolar-arterial oxygen pressure difference, 411.1 ± 70.5 mm Hg versus 597.5 ± 1.3 mm Hg [p < 0.05]). There were no significant differences in pulmonary circulatory hemodynamics between the two groups. Wet to dry lung weight ratio and total volume of airway edema fluid were also significantly less in group I than in group II (group I versus group II: wet to dry ratio, 8.2 ± 0.9 versus 12.1 ± 0.7 [p < 0.01]; edema fluid, 106.7 ± 38.6 mL versus 375.0 ± 56.2 mL [p < 0.01]). There was no difference in lung myeloperoxidase activity between the two groups. We conclude that PGE₁ significantly improved early lung function after transplantation and that this improvement is not due to pulmonary vasodilatation, improved pulmonary circulation, or inhibition of leukocyte activation.

This article has been cited by other articles:

				W. A. den Hengst, J. F. Gielis, J. Y. Lin, P. E. Van Schil, L. J. De Windt, and A. L. Moens Lung ischemia-reperfusion injury: a molecular and clinical view on a complex pathophysiological process Am J Physiol Heart Circ Physiol, November 1, 2010; 299(5): H1283 - H1299. [Abstract] [Full Text] [PDF]

				D. V. Raemdonck, M. Struber, F. Venuta, D. Vlasselaers, W. Wisser, and M. E. Erasmus Strategies in the prevention and the treatment of ischaemia-reperfusion injury after lung transplantation Surgery for Non-Neoplastic Disorders of the Chest: a Clinical Update, June 28, 2010; 66 - 88. [Abstract] [Fulltext] [PDF]

				B. Gohrbandt, S. P. Sommer, S. Fischer, J. M. Hohlfeld, G. Warnecke, A. Haverich, and M. Strueber Iloprost to improve surfactant function in porcine pulmonary grafts stored for twenty-four hours in low-potassium dextran solution J. Thorac. Cardiovasc. Surg., January 1, 2005; 129(1): 80 - 86. [Abstract] [Full Text] [PDF]

				M. de Perrot, M. Liu, T. K. Waddell, and S. Keshavjee Ischemia-Reperfusion-induced Lung Injury Am. J. Respir. Crit. Care Med., February 15, 2003; 167(4): 490 - 511. [Abstract] [Full Text] [PDF]

				M. de Perrot and S. Keshavjee Lung preservation Ann. Thorac. Surg., August 1, 2002; 74(2): 629 - 631. [Full Text] [PDF]

				T. Suda, B. N. Mora, F. D’Ovidio, J. A. Cooper, M. Hiratsuka, W. Zhang, T. Mohanakumar, and G. A. Patterson IN VIVO ADENOVIRUS-MEDIATED ENDOTHELIAL NITRIC OXIDE SYNTHASE GENE TRANSFER AMELIORATES LUNG ALLOGRAFT ISCHEMIA-REPERFUSION INJURY J. Thorac. Cardiovasc. Surg., February 1, 2000; 119(2): 297 - 304. [Abstract] [Full Text] [PDF]

				S. Hillinger, R. A. Schmid, P. Sandera, U. Stammberger, D. Schneiter, G. Schoedon, and W. Weder 8-Br-cGMP is superior to prostaglandin e1 for lung preservation Ann. Thorac. Surg., October 1, 1999; 68(4): 1138 - 1142. [Abstract] [Full Text] [PDF]

				S. Fujino, I. Nagahiro, A. N. Triantafillou, C. H. R. Boasquevisque, M. Yano, J. D. Cooper, and G. A. Patterson Inhaled Nitric Oxide at the Time of Harvest Improves Early Lung Allograft Function Ann. Thorac. Surg., May 1, 1997; 63(5): 1383 - 1389. [Abstract] [Full Text]

				A. Watanabe, N. Kawaharada, K. Kusajima, S. Komatsu, and H. Takahashi Contralateral Lung Injury Associated With Single-Lung Ischemia-Reperfusion Injury Ann. Thorac. Surg., December 1, 1996; 62(6): 1644 - 1649. [Abstract] [Full Text]

				K. Okabayashi, A. N. Triantafillou, M. Yamashita, M. Aoe, S. R. DeMeester, J. D. Cooper, and G. A. Patterson CARDIAC AND PULMONARY REPLACEMENTINHALED NITRIC OXIDE IMPROVES LUNG ALLOGRAFT FUNCTION AFTER PROLONGED STORAGE J. Thorac. Cardiovasc. Surg., August 1, 1996; 112(2): 293 - 299. [Abstract] [Full Text]

				M. Aoe, K. Okabayashi, J. D. Cooper, and G. A. Patterson HYPERINFLATION OF CANINE LUNG ALLOGRAFTS DURING STORAGE INCREASES REPERFUSION PULMONARY EDEMA J. Thorac. Cardiovasc. Surg., July 1, 1996; 112(1): 94 - 102. [Abstract] [Full Text]

				R. J. Novick, K. E. Gehman, I. S. Ali, and J. Lee Lung Preservation: The Importance of Endothelial and Alveolar Type II Cell Integrity Ann. Thorac. Surg., July 1, 1996; 62(1): 302 - 314. [Abstract] [Full Text]

				H. Date, A. N. Triantafillou, E. P. Trulock, M. S. Pohl, J. D. Cooper, and G.A. Patterson INHALED NITRIC OXIDE REDUCES HUMAN LUNG ALLOGRAFT DYSFUNCTION J. Thorac. Cardiovasc. Surg., May 1, 1996; 111(5): 913 - 919. [Abstract] [Full Text]

				R. A. Schmid, M. Yamashita, K. Ando, Y. Tanaka, J. D. Cooper, and G. A. Patterson Lidocaine Reduces Reperfusion Injury and Neutrophil Migration in Canine Lung Allografts Ann. Thorac. Surg., March 1, 1996; 61(3): 949 - 955. [Abstract] [Full Text]