ATS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Erik Fosse
Oddvar Moen
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Fosse, E.
Right arrow Articles by Venge, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fosse, E.
Right arrow Articles by Venge, P.

Ann Thorac Surg 1994;58:472-477
© 1994 The Society of Thoracic Surgeons

Articles

Reduced complement and granulocyte activation with heparin-coated cardiopulmonary bypass

Erik Fosse, MD, PhDa,b,c,*, Oddvar Moen, MDa,b,c, Egil Johnson, MD, PhDa,b,c, Gudmund Semb, MDa,b,c, Vibeke Brockmeier, MDa,b,c, Tom Eirik Mollnes, MD, PhDa,b,c, Magne K. Fagerhol, MD, PhDa,b,c, Per Venge, MD, PhDa,b,c

a Departments of Surgery, Anaesthesiology, and Immunology, Institute for Experimental Medical Research, and Blood Bank, Ullevål Hospital, Oslo, Norway
b Institute of Immunology and Rheumatology, The National Hospital, University of Oslo, Oslo, Norway
c Department of Clinical Chemistry, Uppsala University Hospital, Uppsala, Sweden

Accepted for publication December 15, 1993.

* Address ruprint requests to Dr Fosse, Surgical Department A, The National Hospital, 0027 Oslo, Norway.

Plasma concentrations of the complement activation products C3b, iC3b, and C3c; the terminal C5b-9 complement complex; and the granulocyte proteins calprotectin, myeloperoxidase, and lactoferrin were assessed in two groups of patients undergoing aortocoronary bypass procedures. In 10 patients operated on, the bypass circuits were coated by the Canneda Bio-Active Surface and systemic heparinization was reduced to 1.5 mg/kg; in another 10, the systems were uncoated and the dosage of systemic heparinization was 4 mg/kg. In both groups, significant complement activation was observed after the onset of cardiopulmonary bypass, but the maximum levels of C3b, iC3b, and C3c and the terminal C5b-9 complement complex were significantly lower in the heparin-coated group. In both groups, a significant increase in calprotectin, myeloperoxidase, and lactoferrin release was observed by the end of operation. The maximum myelopeioxidase levels were significantly lower in the heparin-coated group than those in the uncoated group (p = 0.03). There was a correlation of borderline significance between the formation of terminal C5b-9 complement complex and lactoferrin release, as well as between the formation of terminal C5b-9 complement complex and myelopeioxidase release (p = 0.05). The postoperative blood loss did not differ significantly between the two groups. We conclude that coating by end point-attached and functionally active heparin allows a significant reduction in the amount of systemic heparinization, and significantly reduces complement and granulocyte activation.




This article has been cited by other articles:


Home page
 PerfusionHome page
I. Fluger, K. Maderova, M. Simek, R. Hajek, J. Zapletalova, and V. Lonsky
The effect of a cardiopulmonary bypass system with biocompatible coating on fibrinogen levels determined by the TEG - functional fibrinogen method: preliminary results
Perfusion, November 1, 2011; 26(6): 503 - 509.
[Abstract] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
E. Ovrum, G. Tangen, S. Tollofsrud, B. Skeie, M. A. L. Ringdal, R. Istad, and R. Oystese
Heparinized cardiopulmonary bypass circuits and low systemic anticoagulation: An analysis of nearly 6000 patients undergoing coronary artery bypass grafting
J. Thorac. Cardiovasc. Surg., May 1, 2011; 141(5): 1145 - 1149.
[Abstract] [Full Text] [PDF]

Home page
 PerfusionHome page
E. Khoshbin, A. E. Dux, H. Killer, A. W Sosnowski, R. K Firmin, and G. J Peek
A comparison of radiographic signs of pulmonary inflammation during ECMO between silicon and poly-methyl pentene oxygenators
Perfusion, January 1, 2007; 22(1): 15 - 21.
[Abstract] [PDF]

Home page
 Anesth. Analg.Home page
M. E. Jessen
Pro: Heparin-Coated Circuits Should be Used for Cardiopulmonary Bypass
Anesth. Analg., December 1, 2006; 103(6): 1365 - 1369.
[Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
R. D. Frank, U. Muller, R. Lanzmich, C. Groeger, and J. Floege
Anticoagulant-free Genius(R) haemodialysis using low molecular weight heparin-coated circuits
Nephrol. Dial. Transplant., April 1, 2006; 21(4): 1013 - 1018.
[Abstract] [Full Text] [PDF]

Home page
 Eur J Cardiothorac SurgHome page
H. Fujii, S. Suehiro, H. Kumano, T. Shibata, K. Hattori, H. Hirai, and T. Aoyama
Relationship between granulocyte elastase and C3a under protamine dosing in on-pump cardiac surgery
Eur J Cardiothorac Surg, September 1, 2005; 28(3): 431 - 434.
[Abstract] [Full Text] [PDF]

Home page
 PerfusionHome page
E. Khoshbin, C. Westrope, S. Pooboni, D. Machin, H. Killer, G. J Peek, A. W Sosnowski, and R. K Firmin
Performance of polymethyl pentene oxygenators for neonatal extracorporeal membrane oxygenation: a comparison with silicone membrane oxygenators
Perfusion, May 1, 2005; 20(3): 129 - 134.
[Abstract] [PDF]

Home page
 Ann. Thorac. Surg.Home page
F. D. Rubens, H. Nathan, R. Labow, K. S. Williams, D. Wozny, J. Karsh, M. Ruel, and T. Mesana
Effects of Methylprednisolone and a Biocompatible Copolymer Circuit on Blood Activation During Cardiopulmonary Bypass
Ann. Thorac. Surg., February 1, 2005; 79(2): 655 - 665.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
E. Ovrum, G. Tangen, S. Tollofsrud, R. Oystese, M. A. L. Ringdal, and R. Istad
Cold blood cardioplegia versus cold crystalloid cardioplegia: A prospective randomized study of 1440 patients undergoing coronary artery bypass grafting
J. Thorac. Cardiovasc. Surg., December 1, 2004; 128(6): 860 - 865.
[Abstract] [Full Text] [PDF]

Home page
 Eur J Cardiothorac SurgHome page
J. van den Goor, R. Nieuwland, A. van den Brink, W. van Oeveren, P. Rutten, J. Tijssen, and L. Eijsman
Reduced complement activation during cardiopulmonary bypass does not affect the postoperative acute phase response
Eur J Cardiothorac Surg, November 1, 2004; 26(5): 926 - 931.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
E. Ovrum, G. Tangen, S. Tollofsrud, and M. A. L. Ringdal
Heparin-coated circuits and reduced systemic anticoagulation applied to 2500 consecutive first-time coronary artery bypass grafting procedures
Ann. Thorac. Surg., October 1, 2003; 76(4): 1144 - 1148.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
D. J. Goldstein
Worldwide Experience With the MicroMed DeBakey Ventricular Assist Device(R) as a Bridge to Transplantation
Circulation, September 9, 2003; 108(2011): II-272 - II-277.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
E. Jensen, S. Andreasson, A. Bengtsson, H. Berggren, R. Ekroth, L. Lindholm, and J. Ouchterlony
Influence of two different perfusion systems on inflammatory response in pediatric heart surgery
Ann. Thorac. Surg., March 1, 2003; 75(3): 919 - 925.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
G. S. Aldea, L. O. Soltow, W. L. Chandler, C. M. Triggs, C. R. Vocelka, G. I. Crockett, Y. T. Shin, W. E. Curtis, and E. D. Verrier
Limitation of thrombin generation, platelet activation, and inflammation by elimination of cardiotomy suction in patients undergoing coronary artery bypass grafting treated with heparin-bonded circuits
J. Thorac. Cardiovasc. Surg., April 1, 2002; 123(4): 742 - 755.
[Abstract] [Full Text] [PDF]

Home page
 PerfusionHome page
T. Scholz, R. Solberg, C. Okkenhaug, V. Videm, M. J Gallimore, O. Mathisen, T. E Mollnes, A. Bergan, O. Soreide, G. B Klintmalm, et al.
The significance of heparin-coated veno-venous bypass circuits in liver transplantation
Perfusion, January 1, 2002; 17(1): 45 - 50.
[Abstract] [PDF]

Home page
 PerfusionHome page
D. A Palanzo, D. L Zarro, N. J Manley, R. M Montesano, M. Quinn, B.-A. Elmore, P. A Gustafson, and J. M Castagna
Effect of Carmeda(R) BioActive Surface coating versus TrilliumTM Biopassive Surface coating of the oxygenator on circulating platelet count drop during cardiopulmonary bypass
Perfusion, July 1, 2001; 16(4): 279 - 283.
[Abstract] [PDF]

Home page
 Ann. Thorac. Surg.Home page
H. Suhara, Y. Sawa, M. Nishimura, H. Oshiyama, K. Yokoyama, N. Saito, and H. Matsuda
Efficacy of a new coating material, PMEA, for cardiopulmonary bypass circuits in a porcine model
Ann. Thorac. Surg., May 1, 2001; 71(5): 1603 - 1608.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
E. Ovrum, G. Tangen, R. Oystese, M. A. L. Ringdal, and R. Istad
Comparison of two heparin-coated extracorporeal circuits with reduced systemic anticoagulation in routine coronary artery bypass operations
J. Thorac. Cardiovasc. Surg., February 1, 2001; 121(2): 0324 - 330.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
E. A. Grossi, K. Kallenbach, S. Chau, C. C. Derivaux, M. G. Aguinaga, B. M. Steinberg, D. Kim, S. Iyer, M. Tayyarah, M. Artman, et al.
Impact of heparin bonding on pediatric cardiopulmonary bypass: a prospective randomized study
Ann. Thorac. Surg., July 1, 2000; 70(1): 191 - 196.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
J.-O. Defraigne, J. Pincemail, R. Larbuisson, F. Blaffart, and R. Limet
Cytokine release and neutrophil activation are not prevented by heparin-coated circuits and aprotinin administration
Ann. Thorac. Surg., April 1, 2000; 69(4): 1084 - 1091.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
H. Kumano, S. Suehiro, K. Hattori, T. Shibata, Y. Sasaki, M. Hosono, and H. Kinoshita
Coagulofibrinolysis during heparin-coated cardiopulmonary bypass with reduced heparinization
Ann. Thorac. Surg., October 1, 1999; 68(4): 1252 - 1256.
[Abstract] [Full Text] [PDF]

Home page
 Eur J Cardiothorac SurgHome page
C. B. Mahoney and G. M. Lemole
Transfusion after coronary artery bypass surgery: the impact of heparin-bonded circuits
Eur J Cardiothorac Surg, August 1, 1999; 16(2): 206 - 210.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
P. M. McCarthy, J.-P. P. Yared, R. C. Foster, D. A. Ogella, J. A. Borsh, and D. M. Cosgrove III
A prospective randomized trial of Duraflo II heparin-coated circuits in cardiac reoperations
Ann. Thorac. Surg., May 1, 1999; 67(5): 1268 - 1273.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
H. Watanabe, J.-i. Hayashi, H. Ohzeki, H. Moro, M. Sugawara, and S. Eguchi
Biocompatibility of a silicone-coated polypropylene hollow fiber oxygenator in an in vitro model
Ann. Thorac. Surg., May 1, 1999; 67(5): 1315 - 1319.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
A. L. Picone, C. J. Lutz, C. Finck, D. Carney, L. A. Gatto, A. Paskanik, B. Searles, K. Snyder, and G. Nieman
Multiple sequential insults cause post-pump syndrome
Ann. Thorac. Surg., April 1, 1999; 67(4): 978 - 985.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
M. Ranucci, A. Mazzucco, R. Pessotto, G. Grillone, V. Casati, L. Porreca, R. Maugeri, M. Meli, P. Magagna, S. Cirri, et al.
Heparin-coated circuits for high-risk patients: a multicenter, prospective, randomized trial
Ann. Thorac. Surg., April 1, 1999; 67(4): 994 - 1000.
[Abstract] [Full Text] [PDF]

Home page
 PerfusionHome page
S T Baksaas, V Videm, T Pedersen, H Karlsen, T E Mollnes, F Brosstad, and J L Svennevig
Comparison of three oxygenator-coated and one total-circuit-coated extracorporeal devices
Perfusion, March 1, 1999; 14(2): 119 - 127.
[Abstract] [PDF]

Home page
 PerfusionHome page
S. T Baksaas, V. Videm, E. Fosse, H. Karlsen, T. Pedersen, T. E Mollnes, T. A Hagve, and J. L Svennevig
In vitro evaluation of new surface coatings for extracorporeal circulation
Perfusion, January 1, 1999; 14(1): 11 - 19.
[Abstract] [PDF]

Home page
 Ann. Thorac. Surg.Home page
H. H. Schreurs, M. J. Wijers, Y. J. Gu, W. van Oeveren, R. T. van Domburg, J. H. de Boer, and A. J.J.C. Bogers
Heparin-coated bypass circuits: effects on inflammatory response in pediatric cardiac operations
Ann. Thorac. Surg., July 1, 1998; 66(1): 166 - 171.
[Abstract] [Full Text] [PDF]

Home page
 PerfusionHome page
C B. Mahoney
Heparin-bonded circuits: clinical outcomes and costs
Perfusion, May 1, 1998; 13(3): 192 - 204.
[Abstract] [PDF]

Home page
 Ann. Thorac. Surg.Home page
G. S. Aldea, P. O'Gara, O. M. Shapira, P. Treanor, A. Osman, E. Patalis, C. Arkin, R. Diamond, V. Babikian, H. L. Lazar, et al.
Effect of Anticoagulation Protocol on Outcome in Patients Undergoing CABG With Heparin-Bonded Cardiopulmonary Bypass Circuits
Ann. Thorac. Surg., February 1, 1998; 65(2): 425 - 433.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
H. L. Lazar, X. Zhang, T. Hamasaki, C. A. Memmelo, P. Treanor, S. Rivers, G. S. Aldea, S. A. Bernard, and R. J. Shemin
Heparin-Bonded Circuits Decrease Myocardial Ischemic Damage: An Experimental Study
Ann. Thorac. Surg., June 1, 1997; 63(6): 1701 - 1705.
[Abstract] [Full Text]

Home page
 Ann. Thorac. Surg.Home page
R. Lundblad, O. Moen, and E. Fosse
Endothelin-1 and Neutrophil Activation During Heparin-Coated Cardiopulmonary Bypass
Ann. Thorac. Surg., May 1, 1997; 63(5): 1361 - 1367.
[Abstract] [Full Text]

Home page
 PerfusionHome page
H E Hogevold, O Moen, E Fosse, P Venge, J Braten, C Andersson, and T Lyberg
Effects of heparin coating on the expression of CD11b, CD11c and CD62L by leucocytes in extracorporeal circulation in vitro
Perfusion, January 1, 1997; 12(1): 9 - 20.
[Abstract] [PDF]

Home page
 Ann. Thorac. Surg.Home page
C. Baufreton, P. G. M. Jansen, P. Le Besnerais, H. Velthuis, C. M. Thijs, C. R. H. Wildevuur, and D. Y. Loisance
Heparin Coating With Aprotinin Reduces Blood Activation During Coronary Artery Operations
Ann. Thorac. Surg., January 1, 1997; 63(1): 50 - 56.
[Abstract] [Full Text]

Home page
 Ann. Thorac. Surg.Home page
O. Moen, K. Hogasen, E. Fosse, E. Dregelid, V. Brockmeier, P. Venge, M. Harboe, and T. E. Mollnes
Attenuation of Changes in Leukocyte Surface Markers and Complement Activation With Heparin-Coated Cardiopulmonary Bypass
Ann. Thorac. Surg., January 1, 1997; 63(1): 105 - 111.
[Abstract] [Full Text]

Home page
 Ann. Thorac. Surg.Home page
E. M. Boyle Jr, T. H. Pohlman, M. C. Johnson, and E. D. Verrier
Endothelial Cell Injury in Cardiovascular Surgery: The Systemic Inflammatory Response
Ann. Thorac. Surg., January 1, 1997; 63(1): 277 - 284.
[Abstract] [Full Text]

Home page
 PerfusionHome page
C. Baufreton, P. Le Besnerais, P. Jansen, J. P. Mazzucotelli, C. R. Wildevuur, and D. Y Loisance
Clinical outcome after coronary surgery with heparin-coated extracorporeal circuits for cardiopulmonary bypass
Perfusion, November 1, 1996; 11(6): 437 - 443.
[Abstract] [PDF]

Home page
 Ann. Thorac. Surg.Home page
E. Ovrum, E. A. Holen, G. Tangen, and M.-A. L. Ringdal
Heparinized Cardiopulmonary Bypass and Full Heparin Dose Marginally Improve Clinical Performance
Ann. Thorac. Surg., October 1, 1996; 62(4): 1128 - 1133.
[Abstract] [Full Text]

Home page
 Ann. Thorac. Surg.Home page
O. Moen, E. Fosse, E. Dregelid, V. Brockmeier, C. Andersson, K. Hogasen, P. Venge, T. E. Mollnes, and P. Kierulf
Centrifugal Pump and Heparin Coating Improves Cardiopulmonary Bypass Biocompatibility
Ann. Thorac. Surg., October 1, 1996; 62(4): 1134 - 1140.
[Abstract] [Full Text]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
D. D. Muehrcke, P. M. McCarthy, K. Kottke-Marchant, H. Harasaki, J. Pierre-Yared, J. A. Borsh, D. A. Ogella, and D. M. Cosgrove
BIOCOMPATIBILITY OF HEPARIN-COATED EXTRACORPOREAL BYPASS CIRCUITS: A RANDOMIZED, MASKED CLINICAL TRIAL
J. Thorac. Cardiovasc. Surg., August 1, 1996; 112(2): 472 - 483.
[Abstract] [Full Text]

Home page
 Ann. Thorac. Surg.Home page
P. G. M. Jansen, C. Baufreton, P. Le Besnerais, D. Y. Loisance, and C. R. H. Wildevuur
Heparin-Coated Circuits and Aprotinin Prime for Coronary Artery Bypass Grafting
Ann. Thorac. Surg., May 1, 1996; 61(5): 1363 - 1366.
[Abstract] [Full Text]

Home page
 Ann. Thorac. Surg.Home page
H. t. Velthuis, P. G. M. Jansen, C. E. Hack, L. Eijsman, and C. R. H. Wildevuur
Specific Complement Inhibition With Heparin-Coated Extracorporeal Circuits
Ann. Thorac. Surg., April 1, 1996; 61(4): 1153 - 1157.
[Abstract] [Full Text]

Home page
 PerfusionHome page
O. Moen, E. Fosse, J. Braten, C. Andersson, K. Hogasen, T. Mollnes, P. Venge, and P. Kierulf
Differences in blood activation related to roller/centrifugal pumps and heparin coated/uncoated surfaces in a cardiopulmonary bypass model circuit
Perfusion, March 1, 1996; 11(2): 113 - 123.
[Abstract] [PDF]

Home page
 Ann. Thorac. Surg.Home page
E. Ovrum, L. Nilsson, P. Venge, J. W. Borowiec, and S. Thelin
Eosinophil Granulocyte Activation and Heparin-Coated Cardiopulmonary Bypass
Ann. Thorac. Surg., March 1, 1996; 61(3): 1038 - 1039.
[Full Text]

Home page
 Ann. Thorac. Surg.Home page
D. D. Muehrcke, P. M. McCarthy, R. W. Stewart, R. C. Foster, D. A. Ogella, J. A. Borsh, and D. M. Cosgrove III
Extracorporeal Membrane Oxygenation for Postcardiotomy Cardiogenic Shock
Ann. Thorac. Surg., February 1, 1996; 61(2): 684 - 691.
[Abstract] [Full Text]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
R. C. Gorman, N. P. Ziats, A. K. Rao, N. Gikakis, L. Sun, M. M. H. Khan, N. Stenach, S. Sapatnekar, V. Chouhan, J. H. Gorman III, et al.
SURFACE-BOUND HEPARIN FAILS TO REDUCE THROMBIN FORMATION DURING CLINICAL CARDIOPULMONARY BYPASS
J. Thorac. Cardiovasc. Surg., January 1, 1996; 111(1): 1 - 12.
[Abstract] [Full Text]

Home page
 Ann. Thorac. Surg.Home page
E. Ovrum, T. E. Mollnes, E. Fosse, E. Am Holen, G. Tangen, M.-A. L. Ringdal, and V. Videm
High and low heparin dose with heparin-coated cardiopulmonary bypass: Activation of complement and granulocytes
Ann. Thorac. Surg., December 1, 1995; 60(6): 1755 - 1761.
[Abstract] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
E. Ovrum, T. E. Mollnes, E. Fosse, E. A. Holen, G. Tangen, M. Abdelnoor, M.-A. L. Ringdal, R. Oystese, and P. Venge
COMPLEMENT AND GRANULOCYTE ACTIVATION IN TWO DIFFERENT TYPES OF HEPARINIZED EXTRACORPOREAL CIRCUITS
J. Thorac. Cardiovasc. Surg., December 1, 1995; 110(6): 1623 - 1632.
[Abstract] [Full Text]

Home page
 Ann. Thorac. Surg.Home page
O. Moen, E. Fosse, V. Brockmeier, C. Andersson, T. E. Mollnes, K. Hogsen, and P. Venge
Disparity in blood activation by two different heparin-coated cardiopulmonary bypass systems
Ann. Thorac. Surg., November 1, 1995; 60(5): 1317 - 1323.
[Abstract] [PDF]

Home page
 CirculationHome page
E. Ovrum, F. Brosstad, E. Am Holen, G. Tangen, and M. Abdelnoor
Effects on Coagulation and Fibrinolysis With Reduced Versus Full Systemic Heparinization and Heparin-Coated Cardiopulmonary Bypass
Circulation, November 1, 1995; 92(9): 2579 - 2584.
[Abstract] [Full Text]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
P. G. M. Jansen, H. t. Velthuis, R. A. J. M. Huybregts, R. Paulus, E. R. Bulder, H. I. van der Spoel, P. D. Bezemer, E. H. Slaats, L. Eijsman, and C. R. H. Wildevuur
Reduced complement activation and improved postoperative performance after cardiopulmonary bypass with heparin-coated circuits
J. Thorac. Cardiovasc. Surg., September 1, 1995; 110(3): 829 - 834.
[Abstract] [Full Text]

Home page
 Ann. Thorac. Surg.Home page
E. Ovrum, E. Am Holen, G. Tangen, F. Brosstad, M. Abdelnoor, M.-A. L. Ringdal, R. Oystese, and R. Istad
Completely heparinized cardiopulmonary bypass and reduced systemic heparin: Clinical and hemostatic effects
Ann. Thorac. Surg., August 1, 1995; 60(2): 365 - 371.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 1994 by The Society of Thoracic Surgeons.