| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Annals of Thoracic Surgery, Vol 58, 472-477, Copyright © 1994 by The Society of Thoracic Surgeons
E Fosse, O Moen, E Johnson, G Semb, V Brockmeier, TE Mollnes, MK Fagerhol and P Venge
Plasma concentrations of the complement activation products C3b, iC3b, and
C3c; the terminal C5b-9 complement complex; and the granulocyte proteins
calprotectin, myeloperoxidase, and lactoferrin were assessed in two groups
of patients undergoing aortocoronary bypass procedures. In 10 patients
operated on, the bypass circuits were coated by the Carmeda Bio-Active
Surface and systemic heparinization was reduced to 1.5 mg/kg; in another
10, the systems were uncoated and the dosage of systemic heparinization was
4 mg/kg. In both groups, significant complement activation was observed
after the onset of cardiopulmonary bypass, but the maximum levels of C3b,
iC3b, and C3c and the terminal C5b-9 complement complex were significantly
lower in the heparin-coated group. In both groups, a significant increase
in calprotectin, myeloperoxidase, and lactoferrin release was observed by
the end of operation. The maximum myeloperoxidase levels were significantly
lower in the heparin-coated group than those in the uncoated group (p =
0.03). There was a correlation of borderline significance between the
formation of terminal C5b-9 complement complex and lactoferrin release, as
well as between the formation of terminal C5b-9 complement complex and
myeloperoxidase release (p = 0.05). The postoperative blood loss did not
differ significantly between the two groups. We conclude that coating by
end point-attached and functionally active heparin allows a significant
reduction in the amount of systemic heparinization, and significantly
reduces complement and granulocyte activation.
ARTICLES
Reduced complement and granulocyte activation with heparin-coated cardiopulmonary bypass
Department of Surgery, Ulleval Hospital, Oslo, Norway.
This article has been cited by other articles:
|
|
 |
|
  E. Khoshbin, A. E. Dux, H. Killer, A. W Sosnowski, R. K Firmin, and G. J Peek A comparison of radiographic signs of pulmonary inflammation during ECMO between silicon and poly-methyl pentene oxygenators. Perfusion, January 1, 2007; 22(1): 15 - 21. [Abstract] [PDF]
|
|
|
|
 |
|
 M. E. Jessen Pro: Heparin-Coated Circuits Should be Used for Cardiopulmonary Bypass Anesth. Analg., December 1, 2006; 103(6): 1365 - 1369. [Full Text] [PDF]
|
|
|
|
 |
|
 R. D. Frank, U. Muller, R. Lanzmich, C. Groeger, and J. Floege Anticoagulant-free Genius(R) haemodialysis using low molecular weight heparin-coated circuits Nephrol. Dial. Transplant., April 1, 2006; 21(4): 1013 - 1018. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Fujii, S. Suehiro, H. Kumano, T. Shibata, K. Hattori, H. Hirai, and T. Aoyama Relationship between granulocyte elastase and C3a under protamine dosing in on-pump cardiac surgery Eur. J. Cardiothorac. Surg., September 1, 2005; 28(3): 431 - 434. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Khoshbin, C. Westrope, S. Pooboni, D. Machin, H. Killer, G. J Peek, A. W Sosnowski, and R. K Firmin Performance of polymethyl pentene oxygenators for neonatal extracorporeal membrane oxygenation: a comparison with silicone membrane oxygenators Perfusion, May 1, 2005; 20(3): 129 - 134. [Abstract] [PDF]
|
|
|
|
 |
|
 F. D. Rubens, H. Nathan, R. Labow, K. S. Williams, D. Wozny, J. Karsh, M. Ruel, and T. Mesana Effects of Methylprednisolone and a Biocompatible Copolymer Circuit on Blood Activation During Cardiopulmonary Bypass Ann. Thorac. Surg., February 1, 2005; 79(2): 655 - 665. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Ovrum, G. Tangen, S. Tollofsrud, R. Oystese, M. A. L. Ringdal, and R. Istad Cold blood cardioplegia versus cold crystalloid cardioplegia: A prospective randomized study of 1440 patients undergoing coronary artery bypass grafting J. Thorac. Cardiovasc. Surg., December 1, 2004; 128(6): 860 - 865. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. van den Goor, R. Nieuwland, A. van den Brink, W. van Oeveren, P. Rutten, J. Tijssen, and L. Eijsman Reduced complement activation during cardiopulmonary bypass does not affect the postoperative acute phase response Eur. J. Cardiothorac. Surg., November 1, 2004; 26(5): 926 - 931. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Ovrum, G. Tangen, S. Tollofsrud, and M. A. L. Ringdal Heparin-coated circuits and reduced systemic anticoagulation applied to 2500 consecutive first-time coronary artery bypass grafting procedures Ann. Thorac. Surg., October 1, 2003; 76(4): 1144 - 1148. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. J. Goldstein Worldwide Experience With the MicroMed DeBakey Ventricular Assist Device(R) as a Bridge to Transplantation Circulation, September 9, 2003; 108(90101): II-272 - 277. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Jensen, S. Andreasson, A. Bengtsson, H. Berggren, R. Ekroth, L. Lindholm, and J. Ouchterlony Influence of two different perfusion systems on inflammatory response in pediatric heart surgery Ann. Thorac. Surg., March 1, 2003; 75(3): 919 - 925. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. S. Aldea, L. O. Soltow, W. L. Chandler, C. M. Triggs, C. R. Vocelka, G. I. Crockett, Y. T. Shin, W. E. Curtis, and E. D. Verrier Limitation of thrombin generation, platelet activation, and inflammation by elimination of cardiotomy suction in patients undergoing coronary artery bypass grafting treated with heparin-bonded circuits J. Thorac. Cardiovasc. Surg., April 1, 2002; 123(4): 742 - 755. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Scholz, R. Solberg, C. Okkenhaug, V. Videm, M. J Gallimore, O. Mathisen, T. E Mollnes, A. Bergan, O. Soreide, G. B Klintmalm, et al. The significance of heparin-coated veno-venous bypass circuits in liver transplantation Perfusion, January 1, 2002; 17(1): 45 - 50. [Abstract] [PDF]
|
|
|
|
|
|
D. A Palanzo, D. L Zarro, N. J Manley, R. M Montesano, M. Quinn, B.-A. Elmore, P. A Gustafson, and J. M Castagna Effect of Carmeda(R) BioActive Surface coating versus TrilliumTM Biopassive Surface coating of the oxygenator on circulating platelet count drop during cardiopulmonary bypass Perfusion, July 1, 2001; 16(4): 279 - 283. [Abstract] [PDF]
|
|
|
|
|
|
H. Suhara, Y. Sawa, M. Nishimura, H. Oshiyama, K. Yokoyama, N. Saito, and H. Matsuda Efficacy of a new coating material, PMEA, for cardiopulmonary bypass circuits in a porcine model Ann. Thorac. Surg., May 1, 2001; 71(5): 1603 - 1608. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Ovrum, G. Tangen, R. Oystese, M. A. L. Ringdal, and R. Istad Comparison of two heparin-coated extracorporeal circuits with reduced systemic anticoagulation in routine coronary artery bypass operations J. Thorac. Cardiovasc. Surg., February 1, 2001; 121(2): 0324 - 330. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. A. Grossi, K. Kallenbach, S. Chau, C. C. Derivaux, M. G. Aguinaga, B. M. Steinberg, D. Kim, S. Iyer, M. Tayyarah, M. Artman, et al. Impact of heparin bonding on pediatric cardiopulmonary bypass: a prospective randomized study Ann. Thorac. Surg., July 1, 2000; 70(1): 191 - 196. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-O. Defraigne, J. Pincemail, R. Larbuisson, F. Blaffart, and R. Limet Cytokine release and neutrophil activation are not prevented by heparin-coated circuits and aprotinin administration Ann. Thorac. Surg., April 1, 2000; 69(4): 1084 - 1091. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Kumano, S. Suehiro, K. Hattori, T. Shibata, Y. Sasaki, M. Hosono, and H. Kinoshita Coagulofibrinolysis during heparin-coated cardiopulmonary bypass with reduced heparinization Ann. Thorac. Surg., October 1, 1999; 68(4): 1252 - 1256. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. B. Mahoney and G. M. Lemole Transfusion after coronary artery bypass surgery: the impact of heparin-bonded circuits Eur. J. Cardiothorac. Surg., August 1, 1999; 16(2): 206 - 210. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. M. McCarthy, J.-P. P. Yared, R. C. Foster, D. A. Ogella, J. A. Borsh, and D. M. Cosgrove III A prospective randomized trial of Duraflo II heparin-coated circuits in cardiac reoperations Ann. Thorac. Surg., May 1, 1999; 67(5): 1268 - 1273. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Watanabe, J.-i. Hayashi, H. Ohzeki, H. Moro, M. Sugawara, and S. Eguchi Biocompatibility of a silicone-coated polypropylene hollow fiber oxygenator in an in vitro model Ann. Thorac. Surg., May 1, 1999; 67(5): 1315 - 1319. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Picone, C. J. Lutz, C. Finck, D. Carney, L. A. Gatto, A. Paskanik, B. Searles, K. Snyder, and G. Nieman Multiple sequential insults cause post-pump syndrome Ann. Thorac. Surg., April 1, 1999; 67(4): 978 - 985. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ranucci, A. Mazzucco, R. Pessotto, G. Grillone, V. Casati, L. Porreca, R. Maugeri, M. Meli, P. Magagna, S. Cirri, et al. Heparin-coated circuits for high-risk patients: a multicenter, prospective, randomized trial Ann. Thorac. Surg., April 1, 1999; 67(4): 994 - 1000. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S T Baksaas, V Videm, T Pedersen, H Karlsen, T E Mollnes, F Brosstad, and J L Svennevig Comparison of three oxygenator-coated and one total-circuit-coated extracorporeal devices Perfusion, March 1, 1999; 14(2): 119 - 127. [Abstract] [PDF]
|
|
|
|
|
|
S. T Baksaas, V. Videm, E. Fosse, H. Karlsen, T. Pedersen, T. E Mollnes, T. A Hagve, and J. L Svennevig In vitro evaluation of new surface coatings for extracorporeal circulation Perfusion, January 1, 1999; 14(1): 11 - 19. [Abstract] [PDF]
|
|
|
|
|
|
H. H. Schreurs, M. J. Wijers, Y. J. Gu, W. van Oeveren, R. T. van Domburg, J. H. de Boer, and A. J.J.C. Bogers Heparin-coated bypass circuits: effects on inflammatory response in pediatric cardiac operations Ann. Thorac. Surg., July 1, 1998; 66(1): 166 - 171. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C B. Mahoney Heparin-bonded circuits: clinical outcomes and costs Perfusion, May 1, 1998; 13(3): 192 - 204. [Abstract] [PDF]
|
|
|
|
|
|
G. S. Aldea, P. O'Gara, O. M. Shapira, P. Treanor, A. Osman, E. Patalis, C. Arkin, R. Diamond, V. Babikian, H. L. Lazar, et al. Effect of Anticoagulation Protocol on Outcome in Patients Undergoing CABG With Heparin-Bonded Cardiopulmonary Bypass Circuits Ann. Thorac. Surg., February 1, 1998; 65(2): 425 - 433. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. L. Lazar, X. Zhang, T. Hamasaki, C. A. Memmelo, P. Treanor, S. Rivers, G. S. Aldea, S. A. Bernard, and R. J. Shemin Heparin-Bonded Circuits Decrease Myocardial Ischemic Damage: An Experimental Study Ann. Thorac. Surg., June 1, 1997; 63(6): 1701 - 1705. [Abstract] [Full Text]
|
|
|
|
|
|
R. Lundblad, O. Moen, and E. Fosse Endothelin-1 and Neutrophil Activation During Heparin-Coated Cardiopulmonary Bypass Ann. Thorac. Surg., May 1, 1997; 63(5): 1361 - 1367. [Abstract] [Full Text]
|
|
|
|
|
|
H E Hogevold, O Moen, E Fosse, P Venge, J Braten, C Andersson, and T Lyberg Effects of heparin coating on the expression of CD11b, CD11c and CD62L by leucocytes in extracorporeal circulation in vitro Perfusion, January 1, 1997; 12(1): 9 - 20. [Abstract] [PDF]
|
|
|
|
|
|
C. Baufreton, P. G. M. Jansen, P. Le Besnerais, H. Velthuis, C. M. Thijs, C. R. H. Wildevuur, and D. Y. Loisance Heparin Coating With Aprotinin Reduces Blood Activation During Coronary Artery Operations Ann. Thorac. Surg., January 1, 1997; 63(1): 50 - 56. [Abstract] [Full Text]
|
|
|
|
|
|
O. Moen, K. Hogasen, E. Fosse, E. Dregelid, V. Brockmeier, P. Venge, M. Harboe, and T. E. Mollnes Attenuation of Changes in Leukocyte Surface Markers and Complement Activation With Heparin-Coated Cardiopulmonary Bypass Ann. Thorac. Surg., January 1, 1997; 63(1): 105 - 111. [Abstract] [Full Text]
|
|
|
|
|
|
E. M. Boyle Jr, T. H. Pohlman, M. C. Johnson, and E. D. Verrier Endothelial Cell Injury in Cardiovascular Surgery: The Systemic Inflammatory Response Ann. Thorac. Surg., January 1, 1997; 63(1): 277 - 284. [Abstract] [Full Text]
|
|
|
|
|
|
C. Baufreton, P. Le Besnerais, P. Jansen, J. P. Mazzucotelli, C. R. Wildevuur, and D. Y Loisance Clinical outcome after coronary surgery with heparin-coated extracorporeal circuits for cardiopulmonary bypass Perfusion, November 1, 1996; 11(6): 437 - 443. [Abstract] [PDF]
|
|
|
|
|
|
E. Ovrum, E. A. Holen, G. Tangen, and M.-A. L. Ringdal Heparinized Cardiopulmonary Bypass and Full Heparin Dose Marginally Improve Clinical Performance Ann. Thorac. Surg., October 1, 1996; 62(4): 1128 - 1133. [Abstract] [Full Text]
|
|
|
|
|
|
O. Moen, E. Fosse, E. Dregelid, V. Brockmeier, C. Andersson, K. Hogasen, P. Venge, T. E. Mollnes, and P. Kierulf Centrifugal Pump and Heparin Coating Improves Cardiopulmonary Bypass Biocompatibility Ann. Thorac. Surg., October 1, 1996; 62(4): 1134 - 1140. [Abstract] [Full Text]
|
|
|
|
|
|
D. D. Muehrcke, P. M. McCarthy, K. Kottke-Marchant, H. Harasaki, J. Pierre-Yared, J. A. Borsh, D. A. Ogella, and D. M. Cosgrove BIOCOMPATIBILITY OF HEPARIN-COATED EXTRACORPOREAL BYPASS CIRCUITS: A RANDOMIZED, MASKED CLINICAL TRIAL J. Thorac. Cardiovasc. Surg., August 1, 1996; 112(2): 472 - 483. [Abstract] [Full Text]
|
|
|
|
|
|
P. G. M. Jansen, C. Baufreton, P. Le Besnerais, D. Y. Loisance, and C. R. H. Wildevuur Heparin-Coated Circuits and Aprotinin Prime for Coronary Artery Bypass Grafting Ann. Thorac. Surg., May 1, 1996; 61(5): 1363 - 1366. [Abstract] [Full Text]
|
|
|
|
|
|
H. t. Velthuis, P. G. M. Jansen, C. E. Hack, L. Eijsman, and C. R. H. Wildevuur Specific Complement Inhibition With Heparin-Coated Extracorporeal Circuits Ann. Thorac. Surg., April 1, 1996; 61(4): 1153 - 1157. [Abstract] [Full Text]
|
|
|
|
|
|
O. Moen, E. Fosse, J. Braten, C. Andersson, K. Hogasen, T. Mollnes, P. Venge, and P. Kierulf Differences in blood activation related to roller/centrifugal pumps and heparin coated/uncoated surfaces in a cardiopulmonary bypass model circuit Perfusion, March 1, 1996; 11(2): 113 - 123. [Abstract] [PDF]
|
|
|
|
|
|
E. Ovrum, L. Nilsson, P. Venge, J. W. Borowiec, and S. Thelin Eosinophil Granulocyte Activation and Heparin-Coated Cardiopulmonary Bypass Ann. Thorac. Surg., March 1, 1996; 61(3): 1038 - 1039. [Full Text]
|
|
|
|
|
|
D. D. Muehrcke, P. M. McCarthy, R. W. Stewart, R. C. Foster, D. A. Ogella, J. A. Borsh, and D. M. Cosgrove III Extracorporeal Membrane Oxygenation for Postcardiotomy Cardiogenic Shock Ann. Thorac. Surg., February 1, 1996; 61(2): 684 - 691. [Abstract] [Full Text]
|
|
|
|
|
|
R. C. Gorman, N. P. Ziats, A. K. Rao, N. Gikakis, L. Sun, M. M. H. Khan, N. Stenach, S. Sapatnekar, V. Chouhan, J. H. Gorman III, et al. SURFACE-BOUND HEPARIN FAILS TO REDUCE THROMBIN FORMATION DURING CLINICAL CARDIOPULMONARY BYPASS J. Thorac. Cardiovasc. Surg., January 1, 1996; 111(1): 1 - 12. [Abstract] [Full Text]
|
|
|
|
|
|
E. Ovrum, T. E. Mollnes, E. Fosse, E. A. Holen, G. Tangen, M.-A. L. Ringdal, and V. Videm High and Low Heparin Dose With Heparin-Coated Cardiopulmonary Bypass: Activation of Complement and Granulocytes Ann. Thorac. Surg., December 1, 1995; 60(6): 1755 - 1761. [Abstract] [Full Text]
|
|
|
|
|
|
E. Ovrum, T. E. Mollnes, E. Fosse, E. A. Holen, G. Tangen, M. Abdelnoor, M.-A. L. Ringdal, R. Oystese, and P. Venge COMPLEMENT AND GRANULOCYTE ACTIVATION IN TWO DIFFERENT TYPES OF HEPARINIZED EXTRACORPOREAL CIRCUITS J. Thorac. Cardiovasc. Surg., December 1, 1995; 110(6): 1623 - 1632. [Abstract] [Full Text]
|
|
|
|
|
|
O. Moen, E. Fosse, V. Brockmeier, C. Andersson, T. E. Mollnes, K. Hogasen, and P. Venge Disparity in Blood Activation by Two Different Heparin-Coated Cardiopulmonary Bypass Systems Ann. Thorac. Surg., November 1, 1995; 60(5): 1317 - 1323. [Abstract] [Full Text]
|
|
|
|
|
|
E. Ovrum, F. Brosstad, E. Am Holen, G. Tangen, and M. Abdelnoor Effects on Coagulation and Fibrinolysis With Reduced Versus Full Systemic Heparinization and Heparin-Coated Cardiopulmonary Bypass Circulation, November 1, 1995; 92(9): 2579 - 2584. [Abstract] [Full Text]
|
|
|
|
|
|
P. G. M. Jansen, H. t. Velthuis, R. A. J. M. Huybregts, R. Paulus, E. R. Bulder, H. I. van der Spoel, P. D. Bezemer, E. H. Slaats, L. Eijsman, and C. R. H. Wildevuur Reduced complement activation and improved postoperative performance after cardiopulmonary bypass with heparin-coated circuits J. Thorac. Cardiovasc. Surg., September 1, 1995; 110(3): 829 - 834. [Abstract] [Full Text]
|
|
|
|
|
|
E. Ovrum, E. A. Holen, G. Tangen, F. Brosstad, M. Abdelnoor, M.-A. L. Ringdal, R. Oystese, and R. Istad Completely Heparinized Cardiopulmonary Bypass and Reduced Systemic Heparin: Clinical and Hemostatic Effects Ann. Thorac. Surg., August 1, 1995; 60(2): 365 - 371. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| ANN THORAC SURG | ASIAN CARDIOVASC THORAC ANN | EUR J CARDIOTHORAC SURG |
| J THORAC CARDIOVASC SURG | ICVTS | ALL CTSNet JOURNALS |
