HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Hiep C. Nguyen Eugene A. Grossi Bryan M. Steinberg Stephen B. Colvin Aubrey C. Galloway Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Nguyen, H. C. Articles by Galloway, A. C. Search for Related Content PubMed PubMed Citation Articles by Nguyen, H. C. Articles by Galloway, A. C.

Ann Thorac Surg 1994;58:308-311
© 1994 The Society of Thoracic Surgeons

---

Articles

Mammary artery versus saphenous vein grafts: Assessment of basic fibroblast growth factor receptors

Division of Cardtothoracic Surgery, Departments of Surgery and Cell Biology, New York University Medical Center, New York, New York USA

^_* Address reprint requests to Dr Grossi, Division of Cardiovascular Surgery. New York University Medical Conter, 530 First Ave, Ste 6-D, New York, NY 10016.

Neointimal hyperplasia limits the long-term patency of saphenous vein grafts (SVGs), but is notably absent from most internal mammary artery (IMA) grafts. Basic fibroblast growth factor (bFGF) is a local endothelial and vascular smooth muscle mitogen known to be involved in the pathogenesis of neointimal hyperplasia. This study used an animal model to compare the number of available high-affinity (HAR) and low-affinity (LAR) bFGF receptors in SVGs and IMA grafts and to determine whether distention injury causes an increase in receptor availability. The IMA and SVG specimens were harvested from 12 dogs and distended at 25 or 200 mm Hg for 15 minutes, and then the bFGF receptor uptake was measured in them using iodine 125-labeled bFGF. In the IMA conduits distended at low pressure, there were 2.54 ± 0.10 (mean ± standard error of the mean) HARs per mm² of intimai surface area available and 5.19 ± 0.40 LARs per mm². High-pressure distention significantly (p < 0.001) increased the number of available HARs to 5.06 ± 0.27 per mm² and of LARs to 7.27 ± 0.042 per mm². At low pressure, the SVGs had significantly (p < 0.001) more HARs (9.14 ± 0.84 per mm²) and LARs (18.2 ± 0.57 per mm²) available than did the IMA conduits, and high pressure significantly (p < 0.001) increased the number of HARs available in SVGs to 24.1 ± 2.43 per mm² and the number of LARs to 44.7 ± 2.34 per mm². These results demonstrate that there is a significantly higher number of available bFGF receptors per unit of surface area in dog SVGs than IMA grafts. High-pressure distention further increases the differences in the number of available bFGF receptors between SVGs and IMA grafts (p < 0.001). These findings suggest a newly recognized mechanism that may contribute to the increased intimai hyperplasia found in implanted SVGs but not IMAs.

This article has been cited by other articles:

				M. Desai, J. Mirzay-Razzaz, D. von Delft, S. Sarkar, G. Hamilton, and A. M. Seifalian Inhibition of neointimal formation and hyperplasia in vein grafts by external stent/sheath Vascular Medicine, August 1, 2010; 15(4): 287 - 297. [Abstract] [PDF]

				R. Friedl, J. Li, B. Schumacher, H. Hanke, J. Waltenberger, A. Hannekum, and S. Stracke Intimal Hyperplasia and Expression of Transforming Growth Factor-{beta}1 in Saphenous Veins and Internal Mammary Arteries Before Coronary Artery Surgery Ann. Thorac. Surg., October 1, 2004; 78(4): 1312 - 1318. [Abstract] [Full Text] [PDF]

				Y. Ichikawa, H. Kajiwara, Y. Noishiki, I. Yamazaki, K. Yamamoto, T. Kosuge, S. Sato, and Y. Takanashi Flow dynamics in internal thoracic artery grafts 10 years after coronary artery bypass grafting Ann. Thorac. Surg., January 1, 2002; 73(1): 131 - 137. [Abstract] [Full Text] [PDF]

				M. Ojha, R. L. Leask, K. W. Johnston, T. E. David, and J. Butany Histology and morphology of 59 internal thoracic artery grafts and their distal anastomoses Ann. Thorac. Surg., October 1, 2000; 70(4): 1338 - 1344. [Abstract] [Full Text] [PDF]

				J.-M. Farinas, M. Carrier, Y. Hebert, R. Cartier, M. Pellerin, L. P. Perrault, and L. C. Pelletier Comparison of long-term clinical results of double versus single internal mammary artery bypass grafting Ann. Thorac. Surg., February 1, 1999; 67(2): 466 - 470. [Abstract] [Full Text] [PDF]

				J. G. Motwani and E. J. Topol Aortocoronary Saphenous Vein Graft Disease : Pathogenesis, Predisposition, and Prevention Circulation, March 10, 1998; 97(9): 916 - 931. [Abstract] [Full Text] [PDF]

				K. St. Rammos and G. J. Koullias IMMUNOLOCALIZATION OF BASIC FIBROBLAST GROWTH FACTOR RECEPTORS IN INTERNAL THORACIC ARTERY AND SAPHENOUS VEIN GRAFTS J. Thorac. Cardiovasc. Surg., June 1, 1997; 113(6): 1111 - 1112. [Full Text]

				B. Medalion, G. Merin, H. Aingorn, H.-Q. Miao, A. Nagler, A. Elami, R. Ishai-Michaeli, and I. Vlodavsky Endogenous Basic Fibroblast Growth Factor Displaced by Heparin From the Lumenal Surface of Human Blood Vessels Is Preferentially Sequestered by Injured Regions of the Vessel Wall Circulation, April 1, 1997; 95(7): 1853 - 1862. [Abstract] [Full Text]

				J. C.- C. Tsang and R. C.- J. Chiu The phantom of "Myocardial Sinusoids": A historical reappraisal Ann. Thorac. Surg., December 1, 1995; 60(6): 1831 - 1835. [Abstract] [PDF]