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Ann Thorac Surg 1994;58:290-295
© 1994 The Society of Thoracic Surgeons

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Articles

Neoadjuvant therapy: A novel and effective treatment for stage IIIb non-small cell lung cancer

Valerie W. Rusch, MD^{a,b,c,d,e,f,g,_*}, Kathy S. Albain, MD^{a,b,c,d,e,f,g}, Thomas W. Rice, MD^{a,b,c,d,e,f,g}, Vassyl Lonchyna, MD^{a,b,c,d,e,f,g}, Robert McKenna, Jr, MD^{a,b,c,d,e,f,g}, Keith Stelzer, MD^{a,b,c,d,e,f,g}, Robert B. Livingston, MD^{a,b,c,d,e,f,g} The Southwest Oncology Group^{a,b,c,d,e,f,g}

^a Thoracic Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York USA
^b Section of Hematology-Oncology, Department of Medicine, Loyola University Chicago, Maywood, Illinois USA
^c Southwest Oncology Group Statistical Office, Seattle, Washington USA
^d Division of Thoracic Surgery, Cleveland Clinic, Cleveland, Ohio USA
^e Department of Cardiothoracic Surgery, Loyola University Chicago, Maywood, Illinois USA
^f Wilshire Oncology Medical Group, Marion, California USA
^g Department of Radiation Oncology and Division of Medical Oncology, Department of Medicine, University of Washington, Seattle, Washington USA

^_* Address reprint requests to Dr Rusch, Thoracic Service Department of Surgery, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY 10021.

Neoadjuvant therapy has become an accepted treatment for stage IIIa, but not for stage IIIb, non-small cell lung cancer, which is usually considered incurable and treated nonsurgically. We determined the feasibility of neoadjuvant therapy in the setting of stage IIIb non-small cell lung cancer in a prospective multiinstitutional trial. For patients to be eligible for entry into the study, they had to have pathologically documented T1-4 N2-3 disease. Treatment consisted of: (1) cisplatin (50 mg/m²) given on days 1, 8, 29, and 36 plus VP-16 (50 mg/m²) given on days 1 to 5 and 29 to 33, together with concurrent radiotherapy (4,500 cGy; 180 cGy per daily fraction); and (2) surgical resection performed 3 to 5 weeks after induction of medical therapy, if the response was stable, partial, or complete. Of the 126 total eligible patients entered into the study, 51 patients had stage IIIb rumors (24 with T4 tumors and 27 with N3 disease). This consisted of 34 men and 17 women with a median age of 57 years. Thirty-two (63%) patients (18 with T4 tumors and 14 with N3 disease) underwent resection of the primary tumor, with a 5.2% operative mortality. There was no difference in the operative time, blood loss, and length of hospital stay for the T4 versus the N3 patients. For all 51 patients, survival at 2 years was 39%. Sites of relapse in all patients were mainly distant, even though patients with N3 disease did not initially have involved N3 nodes resected. Our experience shows the feasibility of instituting neoadjuvant therapy in patients with stage IIIb non-small cell lung cancer, and suggests that such patients could be included in future trials designed to evaluate the role of surgical resection in the combined-modality treatment of stage III non-small cell lung cancer.

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