ATS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
David A. Fullerton
Max B. Mitchell
Robert C. McIntyre, Jr
James M. Brown
David N. Campbell
Frederick L. Grover
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Fullerton, D. A.
Right arrow Articles by Grover, F. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fullerton, D. A.
Right arrow Articles by Grover, F. L.

Ann Thorac Surg 1994;58:86-92
© 1994 The Society of Thoracic Surgeons

Articles

Mechanisms of coronary vasomotor dysfunction in the transplanted heart

David A. Fullerton, MD*, Max B. Mitchell, MD, Robert C. McIntyre, Jr, MD, James M. Brown, MD, Xianzhong Meng, MD, David N. Campbell, MD, Frederick L. Grover, MD

Department of Surgery, University of Colorado Health Sciences Center, Denver, Colorado USA

* Address reprint requests to Dr Fullerton, Cardiothoracic Surgery, Box C310, University of Colorado Health Sciences Center, 4200 E Ninth Ave, Denver, CO 80262.

The transplanted heart sustains both cold ischemic and reperfusion injuries. These can produce coronary vascular endothelial or smooth muscle injury or both, which, in turn, can produce coronary vasomotor dysfunction. Using a canine model of autologous heart transplantation, we examined the following coronary vasomotor control mechanisms in isolated coronary artery rings: (1) endothelial-dependent cyclic guanosine monophosphate (cGMP)-mediated vasorelaxation (response to acetylcholine); (2) endothelial-independent cGMP-mediated vasorelaxation (response to sodium nitroprusside); and (3) β-adrenergic cyclic adenosine monophosphate (cAMP)-mediated vasorelaxation (response to isoproterenol hydrochloride). Further, these mechanisms were related to 3 hours of cold ischemia alone and to 3 hours of cold ischemia plus 1 hour of reperfusion. Autologous heart transplantation was performed in dogs, and isolated distal left anterior descending coronary artery rings were studied in individual organ chambers. Cold ischemia alone produced significant dysfunction of β-adrenergic cAMP-mediated vasorelaxation, which was exacerbated after reperfusion. Neither endothelial-dependent nor endothelial-independent cGMP-mediated vasorelaxation was dysfunctional after cold ischemia alone, but both were significantly impaired after reperfusion. We conclude that cold ischemia and reperfusion each produce coronary vasomotor dysfunction in the transplanted heart. Cumulatively, such coronary vasomotor dysfunction can acutely impair coronary vasodilatation and potentially jeopardize myocardial blood flow in the transplanted heart.




This article has been cited by other articles:


Home page
 Cardiovasc ResHome page
L. P Perrault, J.-P. Bidouard, P. Janiak, N. Villeneuve, P. Bruneval, J.-P. Vilaine, and P. M Vanhoutte
Impairment of G-protein-mediated signal transduction in the porcine coronary endothelium during rejection after heart transplantation
Cardiovasc Res, August 1, 1999; 43(2): 457 - 470.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
D. Bouchard, M.-A. Despatis, J. Buluran, and R. Cartier
Vascular Effects of Cyclosporin A and Acute Rejection in Canine Heart Transplantation
Ann. Thorac. Surg., November 1, 1997; 64(5): 1325 - 1330.
[Abstract] [Full Text]

Home page
 Ann. Thorac. Surg.Home page
C. O. Murphy, Pan-Chih, J. P. Gott, and R. A. Guyton
Coronary Microvascular Reactivity After Ischemic Cold Storage and Reperfusion
Ann. Thorac. Surg., January 1, 1997; 63(1): 20 - 27.
[Abstract] [Full Text]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
J. Lee, D. C. Drinkwater Jr., H. Laks, A. Chong, A. Blitz, M. A. Chen, L. J. Ignarro, and P. Chang
PRESERVATION OF ENDOTHELIUM-DEPENDENT VASODILATION WITH LOW-POTASSIUM UNIVERSITY OF WISCONSIN SOLUTION
J. Thorac. Cardiovasc. Surg., July 1, 1996; 112(1): 103 - 110.
[Abstract] [Full Text]

Home page
 Ann. Thorac. Surg.Home page
M. Carrier, A. Khalil, A. Tourigny, B. C. Solymoss, and L. C. Pelletier
Effect of L-Arginine on Metabolic Recovery of the Ischemic Myocardium
Ann. Thorac. Surg., June 1, 1996; 61(6): 1651 - 1657.
[Abstract] [Full Text]

Home page
 CirculationHome page
S. F. Davis, A. C. Yeung, I. T. Meredith, F. Charbonneau, P. Ganz, A. P. Selwyn, and T. J. Anderson
Early Endothelial Dysfunction Predicts the Development of Transplant Coronary Artery Disease at 1 Year Posttransplant
Circulation, February 1, 1996; 93(3): 457 - 462.
[Abstract] [Full Text]

Home page
 Ann. Thorac. Surg.Home page
J. Jaggers, D. A. Fullerton, D. N. Campbell, B. Andrea, S. D. Jones, J. M. Brown, E. E. Wolfel, J. Lindenfeld, F. L. Grover, and M. R. Bristow
Cardiac allograft failure: successful use of biventricular assist device
Ann. Thorac. Surg., November 1, 1995; 60(5): 1409 - 1411.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 1994 by The Society of Thoracic Surgeons.