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Ann Thorac Surg 1994;58:207-210
© 1994 The Society of Thoracic Surgeons
Departmenl of Surgery, National Heart & Lung Institute, Heart Science Centre, Harefield Hospital, Harefield, Middlesex, United Kingdom
Accepted for publication December 4, 1993.
* Address reprint requests to Prof Yacoub. Department of Surgery, National Heart & Lung Institute, Heart Science Centre, Harefield Hospital, Harefield, Middlesex UB9 6JH, United Kingdom.
In the inferior epigastric artery, endothelium-dependent relaxations in response to substance P, histamine, and acelylcholine were present. These were greater than reported values in saphenous veins but less than the documented responses in internal mammary and gastroepiploic arteries. Endothelium-independent stimulation with nifedipine, papaverine, sodium nitroprusside, and glyceryl trinitrate induced relaxations that also were reduced compared with established arterial conduits. These findings appear to justify the clinical use of the inferior epigastric artery as a coronary bypass graft with monitoring of its long-term results and possibly perioperative pharmacologic manipulations.
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