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Ann Thorac Surg 1994;58:121-127
© 1994 The Society of Thoracic Surgeons

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Articles

Acute impairment of coronary blood flow by dynamic cardiomyoplasty

Department of Surgery and Department of Medicine, Section of Cardiovascular Sciences, Baylor College of Medicine, Houston, Texas USA

Accepted for publication November 5, 1993.

^_* Address reprint requests to Dr Lawrie, Baylor College of Medicine, 6535 Fannin, Suite A-854, Houston, TX 77030.

The aim of this study was to quantify the effects of three different configurations of cardiomyoplasty on coronary blood flow in an acute dog model. Thirteen dogs had both latissimus dorsi muscles harvested and transposed to the chest. Coronary blood flow was measured using Doppler cuff probes on the left anterior descending and circumflex coronary arteries during each of three cardio-myoplasty configurations: left posterior, right anterior, and double. Multiple beat measures were made of systolic and diastolic flow during a control protocol and a subsequent protocol with the muscle(s) paced. Significant flow reductions during pacing were observed in the left anterior descending coronary artery during left posterior (17%, p = 0.003), right anterior (29%, p < 0.0001), and double (35%, p = 0.0001) myoplasty. Similar reductions occurred in the circumflex artery (14%, p = 0.0009; 20%, p = 0.001; 27%, p = 0.0053). The net flow over an entire pacing cycle also was reduced significantly; left anterior descending artery (11%, p = 0.0035; 23%, p = 0.0001; 23%, p = 0.0047) and circumflex artery (10%, p = 0.0025; 17%, p = 0.0018; 21%, p = 0.0091). Thus, in the acute setting cardiomyoplasty depresses coronary blood flow. A chronic setting will be needed to determine the ultimate significance of these results.

This article has been cited by other articles:

				R. E. Oakley Effect of cardiomyoplasty on coronary artery flow J. Thorac. Cardiovasc. Surg., July 1, 1995; 110(1): 280 - 280. [Full Text]

				T. Tsukube, M. Okada, T. Mukai, and M. A. Kashem Effect of cardiomyoplasty on coronary artery flow J. Thorac. Cardiovasc. Surg., July 1, 1995; 110(1): 280 - 281. [Full Text]