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The Annals of Thoracic Surgery, Vol 58, 121-127, Copyright © 1994 by The Society of Thoracic Surgeons

ARTICLES

Acute impairment of coronary blood flow by dynamic cardiomyoplasty

ER Soltero, DH Glaeser, LH Michael, CJ Hartley, NR Earle and GM Lawrie
Department of Surgery, Baylor College of Medicine, Houston, Texas 77030.

The aim of this study was to quantify the effects of three different configurations of cardiomyoplasty on coronary blood flow in an acute dog model. Thirteen dogs had both latissimus dorsi muscles harvested and transposed to the chest. Coronary blood flow was measured using Doppler cuff probes on the left anterior descending and circumflex coronary arteries during each of three cardiomyoplasty configurations: left posterior, right anterior, and double. Multiple beat measures were made of systolic and diastolic flow during a control protocol and a subsequent protocol with the muscle(s) paced. Significant flow reductions during pacing were observed in the left anterior descending coronary artery during left posterior (17%, p = 0.003), right anterior (29%, p < 0.0001), and double (35%, p = 0.0001) myoplasty. Similar reductions occurred in the circumflex artery (14%, p = 0.0009; 20%, p = 0.001; 27%, p = 0.0053). The net flow over an entire pacing cycle also was reduced significantly: left anterior descending artery (11%, p = 0.0035; 23%, p = 0.0001; 23%, p = 0.0047) and circumflex artery (10%, p = 0.0025; 17%, p = 0.0018; 21%, p = 0.0091). Thus, in the acute setting cardiomyoplasty depresses coronary blood flow. A chronic setting will be needed to determine the ultimate significance of these results.

This article has been cited by other articles:

				R. E. Oakley Effect of cardiomyoplasty on coronary artery flow J. Thorac. Cardiovasc. Surg., July 1, 1995; 110(1): 280 - 280. [Full Text]

				T. Tsukube, M. Okada, T. Mukai, and M. A. Kashem Effect of cardiomyoplasty on coronary artery flow J. Thorac. Cardiovasc. Surg., July 1, 1995; 110(1): 280 - 281. [Full Text]