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Ann Thorac Surg 1994;57:1622-1627
© 1994 The Society of Thoracic Surgeons

Articles

Formaldehyde-free collagen glue in experimental lung gluing

Ina Carolin Ennker, MDa,b,c, Jürgen Ennker, MD*,a,b,c, Doris Schoon, VMDa,b,c, Heinz Adolf Schoon, VMDa,b,c, Manfred Rimpler, PhDa,b,c, Roland Hetzer, MDa,b,c

a Department of Cardiothoracic and Vascular Surgery, German Heart Institute, Berlin, Germany
b Institute of Veterinary Pathology, University of Leipzig, Leipzig, Germany
c Institute of Medicinal Chemistry, Hannover Medical School, Hannover, Germany

Accepted for publication October 28, 1993.

* Address reprint requests to Dr Jürgen Ennker, Department of Cardiothoracic and Vascular Surgery, German Heart Institute Berlin, Augustenburgerplatz 1, 13353 Berlin, Germany.

Because of the well-known limitations of the adhesive strength of fibrin glue, it is imperative to develop a stronger glue with acceptable bioccmpatibility. This was accomplished by removing the formaldehyde component from gelatin-tesoicinol-formaldehyde glue and replacing it by two less toxic aldehydes—pentanedial and ethanedial. To evaluate the adhesive strength of this new glue, GR-DIAL, lung incisions in rabbit hybrids were glued together. Each group (n = 5) was examined histologically after 2 days and 1, 2, and 4 weeks. The glue disintegrated gradually with good bioresorption when the incision was closed with a thin layer of glue. The healing process was favorable, indicating good biocompatibility. Therefore, GR-DIAL glue is capable of enhancing the use of surgical glues in the field of thoracic surgery by enabling surgeons to close larger parenchyma! lesions than with fibrin glue.




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