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Edward L. Bove
Louis A. Brunsting, III
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Richard I. Whyte
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Ann Thorac Surg 1994;57:1545-1548
© 1994 The Society of Thoracic Surgeons

Articles

Selective lung or heart-lung transplantation for pulmonary hypertension associated with congenital cardiac anomalies

Flavian M. Lupinetti, MD*, Steven F. Boiling, MD, Edward L. Bove, MD, Louis A. Brunsting, III, MD, Dennis C. Crowley, MD, Joseph P. Lynch, MD, Mark B. Orringer, MD, Richard I. Whyte, MD, G.Michael Deeb, MD

Section of Thoracic Surgery, Department of Surgery, Division of Pediatric Cardiology, Department of Pediatrics, and Division of Pulmonary Medicine, Department of Medicine, The University of Michigan School of Medicine, Ann Arbor, Michigan, USA

Accepted for publication September 25, 1993.

* Address reprint request to Dr Lupinetti, Division of Cardiovascular Surgery, Children's Hospital and Medical Center. 4800 Sand Point Way, NE, Seattte, WA 98105.

Fixed pulmonary hypertension has been a contraindication to correction of congenital heart defects. Beginning in February 1991, we pursued a policy of performing single-lung transplantation with intracardiac repair for selected patients with this physiology, reserving heart-lung transplantation for those with unreconstructable heart disease. Of 7 patients treated under this protocol, 5 underwent single-lung transplantation and intracardiac repair. The cardiac anomalies included complete atrioventricular canal (1), aortopulmonary window (1), atrial septal defect (1), and ventricular septal defect (2). One patient died perioperatively. All 4 patients surviving operation remained alive through the first postoperative year, but 3 died 13, 17, and 22 months after operation. two other patients with pulmonary hypertension (1 with tricuspid atresia, 1 after failed Mustard procedure) received a heart-lung transplant and are well 15 and 18 that selected patients with major intracardiac defects and pulmonary hypertension may have good early results after cardiac repair and single-lung transplantation, but that long-term results are considerably less favorable.




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