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Ann Thorac Surg 1994;57:1484-1491
© 1994 The Society of Thoracic Surgeons

Articles

Performance of an intravenous gas exchanger (IVOX) in a venovenous bypass circuit

Weike Tao, MD, Joseph B. Zwischenberger, MD*, Thuan T. Nguyen, MD, Alexander E. Tzouanakis, MD, Edward J. Matheis, MD, Daniel L. Traber, PhD, Akhil Bidani, MD, PhD

Departments of Surgery, Internal Medicine, and Anesthesiology, University of Texas Medical Branch and Shriners Burns Institute, Galveston, Texas, USA

* Address reprint requests to Dr Zwischenberger, Cardiothoracic Surgery, University of Texas Medical Branch, Galveston, TX 77555-0528.

To analyze quantitatively the performance of the intravenacaval blood gas exchanger (IVOX), we developed a right atrium-pulmonary artery venovenous extracorporeal bypass circuit Oxygen transfer and carbon dioxide removal were calculated at different blood flow rates, different hemoglobin levels, and during permissive hypercapnia. Oxygen transfer increased linearly with blood flow up to 41 mL/min. Likewise, O2 transfer increased linearly with hemoglobin levels up to 7. 5 g/dL, but no further increases were achieved above this level. Carbon dioxide removal increased linearly as flow increased from 1.0 to 3.0 L/min but did not increase further for higher flows. Carbon dioxide removal was 45 mL/min at blood carbon dioxide tension of 42 mm Hg but increased to a maximum of 81 mL/min at a carbon dioxide tension of 90 mm Hg. We conclude that IVOX is a diffusion-limited device dependent on blood flow, hemoglobin content, and the gas pressure gradient across the membrane. Further engineering improvements are needed to improve the gas exchange performance of IVOX.




This article has been cited by other articles:


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 PerfusionHome page
J. B Zwischenberger, S. K Alpard, S. A Conrad, R. H Johnigan, and A. Bidani
Arteriovenous carbon dioxide removal: development and impact on ventilator management and survival during severe respiratory failure
Perfusion, July 1, 1999; 14(4): 299 - 310.
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