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The Annals of Thoracic Surgery, Vol 57, 1126-1132, Copyright © 1994 by The Society of Thoracic Surgeons

ARTICLES

Induction therapy for squamous carcinoma of thoracic esophagus

E Laterza, C Griso, US Urso, G de Manzoni, M Malago, C Oliani and C Cordiano
First Department of General Surgery, University of Verona, Italy.

From June 1987 to March 1992, 70 patients with squamous cell carcinoma of the esophagus were entered into a treatment protocol that included a preoperative course of radiotherapy (3,000 cGy) and chemotherapy (cisplatin and 5-fluorouracil). The preoperative therapy was well tolerated. Forty-nine of these patients underwent esophageal resection (total or subtotal) and 6 patients died subsequently (12.2%). The morbidity was not dramatically affected by preoperative treatment. Histopathologic studies showed no residual disease in the resected specimen of 11 patients (19.2%), only some residual microscopic clusters of neoplastic cells in 8 patients (14%) and macroscopic cancer in the remaining patients (66.8%). The estimated overall Kaplan-Meier survival at 1, 2, and 3 years was 53.6%, 28.6%, and 21.5%, respectively. Our study, like other reports, demonstrates an improved survival in the group of patients who had a complete response after radiotherapy or chemotherapy (p = 0.002). Moreover, the lack of diagnostic procedures to evaluate the presence of residual tumor after radiotherapy and chemotherapy, suggests that only surgical resection can provide an accurate prognostic information and a complete treatment.

This article has been cited by other articles:

				G. de Manzoni, C. Pedrazzani, E. Laterza, F. Pasini, A. Grandinetti, M. Bernini, A. Ruzzenente, G. Zerman, A. Tomezzoli, and C. Cordiano Induction Chemoradiotherapy for Squamous Cell Carcinoma of the Thoracic Esophagus: Impact of Increased Dosage on Long-Term Results Ann. Thorac. Surg., October 1, 2005; 80(4): 1176 - 1183. [Abstract] [Full Text] [PDF]

				E. Laterza, G. de Manzoni, A. Guglielmi, L. Rodella, P. Tedesco, and C. Cordiano Endoscopic ultrasonography in the staging of esophageal carcinoma after preoperative radiotherapy and chemotherapy Ann. Thorac. Surg., May 1, 1999; 67(5): 1466 - 1469. [Abstract] [Full Text] [PDF]

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