HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Jun Amano Akio Suzuki Makoto Sunamori Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Amano, J. Articles by Sunamori, M. Search for Related Content PubMed PubMed Citation Articles by Amano, J. Articles by Sunamori, M.

Ann Thorac Surg 1994;57:928-932
© 1994 The Society of Thoracic Surgeons

---

Articles

Effects of cardiac denervation on coronary and systemic circulation

Department of Cardiothoracic Surgery, Tokyo Medical and Dental University, Tokyo, Japan

Accepted for publication July 30, 1993.

^_* Address reprint requests to Dr Amano, Department of Cardiothoracic Surgery, Tokyo Medical and Dental University, 1-5-45, Yushima, BunkyoKu, Tokyo, 113, Japan.

The effects of cardiac denervation on coronary circulation and systemic hemodynamics were examined in patients who underwent coronary artery bypass grafting for a totally occluded left anterior descending coronary artery. The results in 14 patients who had undergone a combination of bypass grafting and intrapericardial denervation (group I) were compared with those in 19 patients who had undergone only bypass grafting (group II). The heart rate was 110 ± 4.9 beats/min in group I and 104 ± 3.7 beats/min in group II after denervation. Although the cardiac index was not significantly different between the two groups, the calculated systemic vascular resistance index of group I (1,35B ± 111 dynes · s · cm^–5 · m²) was significantly lower (p < 0.02) than that in group II (1,713 ± 75 dynes · s · cm^–5 · m²). The end-diastolic coronary resistance was significantly lower (p < 0.05) in group I (0.59 ± 0.05 mm Hg · mL^–1 · min^–1) than that in group II (1.04 ± 0.14 mm Hg · mL^–1 · min^–1), and the enddiastolic graft flow/mean graft flow ratio was 1.56 ± 0.05 in group I and 1.28 ± 0.04 in group II (p < 0.01). The plasma norepinephrine concentration in group I (223 ± 52 pg/mL) was significantly low (p < 0.05) compared with that in group II (328 ± 39 pg/mL) after denervation. Thus, cardiac denervation may have a beneficial effect on systemic hemodynamics and coronary circulation.

This article has been cited by other articles:

				I. Bakir, F. P. Casselman, P. Brugada, P. Geelen, F. Wellens, I. Degrieck, F. Van Praet, Y. Vermeulen, R. De Geest, and H. Vanermen Current Strategies in the Surgical Treatment of Atrial Fibrillation: Review of the Literature and Onze Lieve Vrouw Clinic's Strategy Ann. Thorac. Surg., January 1, 2007; 83(1): 331 - 340. [Abstract] [Full Text] [PDF]

				J. Melo, P. Voigt, B. Sonmez, M. Ferreira, M. Abecasis, M. Rebocho, A. Timoteo, C. Aguiar, S. Tansal, H. Arbatli, et al. Ventral cardiac denervation reduces the incidence of atrial fibrillation after coronary artery bypass grafting J. Thorac. Cardiovasc. Surg., February 1, 2004; 127(2): 511 - 516. [Abstract] [Full Text] [PDF]