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Ann Thorac Surg 1994;57:657-662
© 1994 The Society of Thoracic Surgeons

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Articles

Effect of triiodothyronine on postischemic myocardial function in the isolated heart

Division of Cardiothoracic Surgery, Medical College of Virginia-Virginia Commonwealth University, Richmond, Virginia USA

Accepted for publication May 25, 1993.

^_* Address reprint requests to dr Wechsler, Department of Surgery, Medical College of Virginia, MCV Station BOX 645, Richmond, VA 23298-0645.

Thyroid dysfunction has been shown to have a significant impact on hemodynamic status and cardiac function. The purpose of this study was to determine the influence of triiodothyronine (T₃) on cardiac functional recovery after ischemia in a dose-dependent manner. Postischemic functional recovery was assessed in isolated rabbit hearts mounted in a modified Langendorff preparation. Left ventricular systolic, diastolic, and peak developed pressures were measured before and after ischemia, and calculated as a percentage of preischemic function. Two cohorts of hearts were studied: the first was exposed to warm ischemia until a myocardial contracture of 4 mm Hg was produced; the second cohort was exposed to warm ischemia until a contracture of 15 mm Hg was observed. In each cohort, T₃ was added to the perfusion solution after ischemia in a physiologic concentration (2.5 x 10^–9 g/mL; 1 x T₃), as well as ten times (2.5 x 10^–8 g/ml; 10 x T₃ and a hundred times (2.5 x 10^–7 g/mL; 100 x T₃) the physiologic concentration. One group, given the carrier only but without T₃, served as the control. Rabbit hearts exposed to a short period of ischemia (4-mm Hg diastolic contracture) showed increased recovery with 1 x T₃ and 10 x T₃,100 x T₃ did not bring about improved left ventricular recovery versus that in the control group. Rabbit hearts in the 15 mm Hg-diastolic contracture cohort showed increased recovery with 10 x T₃ but not with 1 x T₃. 100 x T₃ led to decreased recovery in this cohort versus that in the control group. T₃ supplementation had no influence either on the wet-dry weight ratio of myocardium, measured at the end of reperfusion, or on coronary flow throughout the postischemic period. These findings indicate that T₃ enhances recovery after ischemia in a relatively dose-dependent fashion over a wide therapeutic range.

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				Q. Liu, A. S. Clanachan, and G. D. Lopaschuk Acute effects of triiodothyronine on glucose and fatty acid metabolism during reperfusion of ischemic rat hearts Am J Physiol Endocrinol Metab, September 1, 1998; 275(3): E392 - E399. [Abstract] [Full Text] [PDF]

				J. D. Klemperer, J. Zelano, R. E. Helm, K. Berman, K. Ojamaa, I. Klein, O. W. Isom, and K. Krieger Triiodothyronine improves left ventricular function without oxygen wasting effects after global hypothermic ischemia J. Thorac. Cardiovasc. Surg., March 1, 1995; 109(3): 457 - 465. [Abstract] [Full Text]