HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Mark W. Turrentine Kenneth A. Kesler Yousuf Mahomed John W. Brown Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Turrentine, M. W. Articles by Brown, J. W. Search for Related Content PubMed PubMed Citation Articles by Turrentine, M. W. Articles by Brown, J. W.

Ann Thorac Surg 1994;57:546-554
© 1994 The Society of Thoracic Surgeons

---

Articles

Cardiac transplantation in infants and children

Departments of Surgery, Pediatrics, and Anesthesia, Riley Hospital for Children, Indiana University Medical Center, Indianapolis, Indiana USA

^_* Address reprint requests to Dr Turrentine, Indiana University Medical Center, 545 Bamhill Dr, EM #212, Indianapolis, IN 46202-5125.

Cardiac transplantation has become a more frequently used therapeutic modality for select cardiac pathology in infants and children. Since June 1986, 30 pediatric patients (19 male and 11 female) ranging in age from 4 days to 15 years (11 1 month old) have undergone orthotopic cardiac transplantation at our institution. Indications included idiopathic cardiomyopathy (n = 8), hypoplastic left heart syndrome (n = 13), and other forms of complex congenital heart disease (n = 9). There have been four operative and three late deaths only in the groups with hypoplastic left heart syndrome and other forms of complex congenital heart disease. Cumulative survival is 77% after a mean follow-up of 30 months (range, 6 to 77 months). Three operative deaths were attributable to pulmonary hypertension, and the other was due to pulmonary hemorrhage. Two late deaths were secondary to allograft rejection, and the third was due to infection. There has been uniform survival in the group with idiopathic cardiomyopathy, and intermediate-term survival rates are 78% and 62% in the groups with complex congenital heart diseases and hypoplastic left heart syndrome, respectively (p = 0.15). Although longer-term results are necessary, orthotopic cardiac transplantation appears to be an acceptable mode of therapy for end-stage heart disease in the pediatric age group and technically can be performed despite complex malformations of the great arteries or atria.

This article has been cited by other articles:

				M. B. Mitchell, D. N. Campbell, M. M. Boucek, H. M. Sondheimer, K. C. Chan, D. D. Ivy, B. Pietra, and T. Mackenzie Mechanical limitation of pulmonary blood flow facilitates heart transplantation in older infants with hypoplastic left heart syndrome Eur J Cardiothorac Surg, May 1, 2003; 23(5): 735 - 742. [Abstract] [Full Text] [PDF]

				M. B. Mitchell, D. N. Campbell, D. R. Clarke, D. A. Fullerton, F. L. Grover, M. M. Boucek, B. Pietra, M. Luna, A. L. Shroyer, J. R. Coll, et al. Infant heart transplantation: improved intermediate results J. Thorac. Cardiovasc. Surg., August 1, 1998; 116(2): 242 - 246. [Abstract] [Full Text] [PDF]

				A. J. Razzouk, R. E. Chinnock, S. R. Gundry, J. K. Johnston, R. L. Larsen, M. F. Baum, N. F. Mulla, and L. L. Bailey Transplantation as a Primary Treatment for Hypoplastic Left Heart Syndrome: Intermediate-Term Results Ann. Thorac. Surg., July 1, 1996; 62(1): 1 - 7. [Abstract] [Full Text]

				K. Bando, M. W. Turrentine, K. Sun, T. G. Sharp, R. L. Caldwell, R. K. Darragh, G. J. Ensing, T. M. Cordes, T. Flaspohler, and J. W. Brown Surgical Management of Hypoplastic Left Heart Syndrome Ann. Thorac. Surg., July 1, 1996; 62(1): 70 - 76. [Abstract] [Full Text]