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The Annals of Thoracic Surgery, Vol 57, 450-457, Copyright © 1994 by The Society of Thoracic Surgeons
S Steen, PO Kimblad, T Sjoberg, L Lindberg, R Ingemansson and G Massa
The function of six porcine left lung allografts was studied after
pulmonary (140 mL/kg) and bronchial (50 mL/kg) artery perfusion with
Perfadex (Kabi Pharmacia, Uppsala, Sweden) at room temperature, followed by
24-hour storage of the lungs in an atelectatic state in 6 degrees to 8
degrees C Perfadex, which is a low-potassium-dextran solution. Left lung
transplantation was done followed by right pneumonectomy, thereby making
all the animals 100% dependent for their survival on the transplanted
lungs. The pigs (mean weight = 56 kg, range = 51 to 58 kg, n = 18; 6
donors, 6 recipients, and 6 sham operated) were ventilated with a
volume-controlled ventilator (20 breaths/min, 500 mL tidal volume, 8 cm H2O
positive end-expiratory pressure, inspired oxygen fraction = 0.5). All the
transplanted animals were in good condition throughout the 24-hour
observation period with arterial oxygen tensions around 25 kPa (188 mm Hg)
and arterial carbon dioxide tensions around 5 kPa (38 mm Hg). The mean
pulmonary arterial pressure was around 30 mm Hg, and the pulmonary vascular
resistance around 500 dyn.s.cm-5; neither showed any tendency to change
with time. After 24 hours the inspired oxygen fraction was increased to 1.0
and the arterial oxygen tension increased to 43.3 +/- 5 kPa (325 +/- 38 mm
Hg) (mean +/- standard error of the mean; n = 6). A sham operation
(bilateral thoracotomy, right pneumonectomy) was done in 6 pigs, which were
followed up for 24 hours.(ABSTRACT TRUNCATED AT 250 WORDS)
ARTICLES
Safe lung preservation for twenty-four hours with Perfadex
Department of Cardiothoracic Surgery, University Hospital of Lund, Sweden.
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