HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Johannes M. Albes Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Albes, J. M. Articles by Borst, H.-G. Search for Related Content PubMed PubMed Citation Articles by Albes, J. M. Articles by Borst, H.-G.

Ann Thorac Surg 1994;57:444-449
© 1994 The Society of Thoracic Surgeons

---

Articles

Improvement of tracheal autograft revascularization by means of fibroblast growth factor

^a Division of Thoracic and Cardiovascular Surgery, Surgical Center, Hannover, Germany
^b Department of Nuclear Medicine, Hannover Medical School, Hannover, Germany
^c Department of Ultrastructure Research, Fraunhofer Institute of Toxicology and Aerosol Research, Hannover, Germany

Accepted for publication April 30, 1993.

^_* Address reprint requests to Dr Schäfers, Klinik für Thorax-, Herz- und Gefäβchirurgie, Medizinische Hochschule Hannover, Konstanty-Gutsehow-Str 8, 3000 Hannover 61, Germany.

Ischemic airway complications after lung transplantation remain a significant problem despite the use of bronchial omentopexy. Clinical observations suggest that enhancement of vascular ingrowth could possibly increase the efficacy of a bronchial omental flap. This study was therefore designed to investigate whether basic fibroblast growth factor can enhance blood supply of an ischemic airway by acceleration of vascular ingrowth in a rabbit autotransplant model. Segments of the trachea were harvested and transplanted into a subcutaneous pouch. The animals were randomly assigned to one of four groups: group I, no omentopexy; group II, omentopexy; group III, omentopexy and fibrin glue; or group IV, omentopexy and fibrin glue enriched with 2.5 µg basic fibroblast growth factor. After 14 days the animals were sacrificed. The extent of perfusion was investigated by means of radioactive microspheres. The morphology of the tracheal segments was investigated in a blinded fashion macroscopically, by means of light microscopy, and by means of scanning electron microscopy. The radioactivity measurements revealed a significantly increased perfusion of group IV (77% ± 42%) as compared with groups I (17% ± 13%) and III (20% ± 16%). By macroscopic and light microscopic assessment, the epithelial integrity of group IV was significantly improved compared with groups I and II. At electron microscopy the integrity of group IV was significantly superior to all remaining groups. We conclude that a deposit of basic fibroblast growth factor and fibrin glue appears to increase revascularization of an ischemic airway from omentum and thus results in improved epithelial preservation of a tracheal autograft.

This article has been cited by other articles:

				M. Behrend, R. von Wasielewski, and J. Klempnauer Failure of airway healing in an ovine autotransplantation model that includes basic fibroblast growth factor J. Thorac. Cardiovasc. Surg., August 1, 2002; 124(2): 231 - 240. [Abstract] [Full Text] [PDF]

				K. Kojima, L. J. Bonassar, A. K. Roy, C. A. Vacanti, and J. Cortiella Autologous tissue-engineered trachea with sheep nasal chondrocytes J. Thorac. Cardiovasc. Surg., June 1, 2002; 123(6): 1177 - 1184. [Abstract] [Full Text] [PDF]

				A. Dodge-Khatami, C. L. Backer, L. D. Holinger, C. Mavroudis, K. E. Cook, and S. E. Crawford Healing of a free tracheal autograft is enhanced by topical vascular endothelial growth factor in an experimental rabbit model J. Thorac. Cardiovasc. Surg., September 1, 2001; 122(3): 554 - 561. [Abstract] [Full Text] [PDF]

				S. W. Sung and T. Won Effects of basic fibroblast growth factor on early revascularization and epithelial regeneration in rabbit tracheal orthotopic transplantation Eur J Cardiothorac Surg, January 1, 2001; 19(1): 14 - 18. [Abstract] [Full Text] [PDF]

				P. Pecher and B. A. Schumacher Angiogenesis in ischemic human myocardium: clinical results after 3 years Ann. Thorac. Surg., May 1, 2000; 69(5): 1414 - 1419. [Abstract] [Full Text] [PDF]

				E. Jadczuk High doses of hydrocortisone improved tracheal autograft revascularization Eur J Cardiothorac Surg, December 1, 1998; 14(6): 615 - 620. [Abstract] [Full Text] [PDF]

				B. Schumacher, P. Pecher, B. U. von Specht, and Th. Stegmann Induction of Neoangiogenesis in Ischemic Myocardium by Human Growth Factors : First Clinical Results of a New Treatment of Coronary Heart Disease Circulation, February 24, 1998; 97(7): 645 - 650. [Abstract] [Full Text] [PDF]

				R. Nakanishi, N. Nagaya, T. Yoshimatsu, T. Hanagiri, and K. Yasumoto OPTIMAL DOSE OF BASIC FIBROBLAST GROWTH FACTOR FOR LONG-SEGMENT ORTHOTOPIC TRACHEAL AUTOGRAFTS J. Thorac. Cardiovasc. Surg., January 1, 1997; 113(1): 26 - 36. [Abstract] [Full Text]