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Ann Thorac Surg 1994;57:214-216
© 1994 The Society of Thoracic Surgeons
Department of Thoracic Surgery and the Vanderbilt Transplant Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA
Accepted for publication March 19, 1993.
* Address reprint requests to Dr Frist, Department of Thoracic Surgery, Vanderbilt University Medical Center, TVC 2973, Nashville, TN 37232-5734.
We have previously reported a case of recurrent cardiac rejection in a heart transplant recipient successfully treated with total lymphoid irradiation. Five years after transplantation chronic myelogenous leukemia was diagnosed in this patient. The long-term effects of total lymphoid irradiation in the heart transplant population have not been reported. Based on the known relationships among irradiation, gene translocations, and leukemia, we postulate that this patient's chronic myelogenous leukemia may be a long-term sequela of previous total lymphoid irradiation.
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