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The Annals of Thoracic Surgery, Vol 57, 214-216, Copyright © 1994 by The Society of Thoracic Surgeons

ARTICLES

Chronic myelogenous leukemia after lymphoid irradiation and heart transplantation

WH Frist and VJ Biggs
Department of Thoracic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee 37232-5734.

We have previously reported a case of recurrent cardiac rejection in a heart transplant recipient successfully treated with total lymphoid irradiation. Five years after transplantation chronic myelogenous leukemia was diagnosed in this patient. The long-term effects of total lymphoid irradiation in the heart transplant population have not been reported. Based on the known relationships among irradiation, gene translocations, and leukemia, we postulate that this patient's chronic myelogenous leukemia may be a long-term sequela of previous total lymphoid irradiation.


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 J Am Coll CardiolHome page
S. A. Hunt and F. Haddad
The Changing Face of Heart Transplantation
J. Am. Coll. Cardiol., August 19, 2008; 52(8): 587 - 598.
[Abstract] [Full Text] [PDF]


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