|
|
||||||||
Ann Thorac Surg 1994;57:177-182
© 1994 The Society of Thoracic Surgeons
Department of Surgery, Tottori University School of Medicine, Yonago, Japan
Accepted for publication March 15, 1993.
* Address reprint requests to Dr Mori, Second Department of Surgery, Tottori University School of Medicine, 36-1 Nishi-machi, Yonago, Tottori 683, Japan.
The cardioprotective effect of the magnesium and calcium content of hyperkalemic cardioplegic solutions was investigated using isolated rat hearts subjected to hypothermic ischemic arrest. Hearts were arrested for 180 minutes at 20 °C by administering a 3-minute infusion of cardioplegic solution containing various concentrations of magnesium and calcium. Treatment groups received solution with either 0, 8, or 16 mmol/L magnesium. For each of these magnesium concentrations, 0.1, 0.6, or 1.2 mmol/L calcium was also present in the solution. At each concentration of magnesium, the percentage recovery of aortic flow was dependent on the calcium concentration. The maximum percentage recovery of aortic flow was 67.9% ± 2.3% (mean
standard error of the mean) in the Mg-free, 0.1 mmol/L Ca group, whereas it was 65.1% ± 2.7% in the 8 mmol/L Mg, 0.1 mmol/L Ca group and 70.0% ± 3.5% in the 16 mmol/L Mg, 0.6 mmol/L Ca group. No significant differences in the recovery of cardiac function and creatine kinase leakage were observed between the three groups. The findings suggested that the cardioprotective effect was dependent on the relative concentration of both magnesium and calcium, and that it is important to maintain an appropriate ionic balance in cardioplegic solutions.
This article has been cited by other articles:
![]() |
Y. Maruyama and D. J. Chambers Myocardial protection: efficacy of a novel magnesium-based cardioplegia (RS-C) compared to St Thomas' Hospital cardioplegic solution Interact CardioVasc Thorac Surg, October 1, 2008; 7(5): 797 - 797. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. J Griffiths Calcium handling and cell contraction in rat cardiomyocytes depleted of intracellular magnesium Cardiovasc Res, July 1, 2000; 47(1): 116 - 123. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y. Nakamura, H. Kuroda, N. Takemoto, S. Ohgi, and T. Mori Risk of low calcium and high magnesium in continuous warm hyperkalemic cardioplegia Ann. Thorac. Surg., October 1, 1999; 68(4): 1295 - 1301. [Abstract] [Full Text] [PDF] |
||||
![]() |
P. Menasche Blood Cardioplegia: Do We Still Need to Dilute? Ann. Thorac. Surg., October 1, 1996; 62(4): 957 - 960. [Full Text] |
||||
![]() |
R. Karmy-Jones, A. Hamilton, V. Dzavik, M. Allegreto, B. A. Finegan, and A. Koshal Magnesium sulfate prophylaxis after cardiac operations Ann. Thorac. Surg., February 1, 1995; 59(2): 502 - 507. [Abstract] [PDF] |
||||
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| ANN THORAC SURG | ASIAN CARDIOVASC THORAC ANN | EUR J CARDIOTHORAC SURG |
| J THORAC CARDIOVASC SURG | ICVTS | ALL CTSNet JOURNALS |