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The Annals of Thoracic Surgery, Vol 57, 157-160, Copyright © 1994 by The Society of Thoracic Surgeons

ARTICLES

Induction of heat-shock proteins enhances myocardial and endothelial functional recovery after prolonged cardioplegic arrest

M Amrani, J Corbett, NJ Allen, J O'Shea, SY Boateng, AJ May, MJ Dunn and MH Yacoub
Cardiothoracic Surgery Department, National Heart and Lung Institute, London, England.

The aim of this study was to investigate the role of heat-shock proteins after heat-shock stress on the post-ischemic recovery of cardiac mechanical and endothelial function following a prolonged cardiac arrest. Isolated working rat hearts were subjected to a cardioplegic arrest for 4 hours at 4 degrees C. Three groups (n = 8 in each) were studied: (1) control, (2) sham-treated, and (3) heat-shocked rats. Postischemic recovery of cardiac output and endothelial function (as percent of preischemic control values) was 57.8% +/- 2.8% and 20.8% +/- 3.9% in group 1, 50.9% +/- 4.0% and 26.3% +/- 5.9% in group 2, and 74.0% +/- 2.4% and 51.2% +/- 8.0% in group 3, respectively. Both postischemic myocardial and endothelial function were improved by heat stress.

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