ATS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 QUICK SEARCH:   [advanced]


     


This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Hikaru Matsuda
Ryota Shirakura
Norihide Fukushima
Kazuhiro Taniguchi
Susumu Nakano
Yasunaru Kawashima
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Matsuwaka, R.
Right arrow Articles by Kawashima, Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Matsuwaka, R.
Right arrow Articles by Kawashima, Y.

Ann Thorac Surg 1994;57:151-156
© 1994 The Society of Thoracic Surgeons


Articles

Changes in left ventricular performance after global ischemia: Assessing LV pressure-volume relationship

Ryousuke Matsuwaka, MD*, Hikaru Matsuda, MD, Ryota Shirakura, MD, Mitsunori Kaneko, MD, Norihide Fukushima, MD, Kazuhiro Taniguchi, MD, Susumu Nakano, MD, Yasunaru Kawashima, MD

First Department of Surgery, Osaka University Medical School, Osaka, Japan

Accepted for publication February 25, 1993.

* Address reprint requests to Dr Matsuwaka, First Department of Surgery, Osaka University Medical School, 2-2, Yamadaoka, Suita, 565, Osaka, Japan.

To determine the effect of ischemia and reperfusion on left ventricular systolic function, we studied the ischemia-induced rightward shift of the ventricular pressure-volume relationship. Eight mongrel dogs were intubated, and their hearts were exposed through a thoracotomy. A conductance catheter and micromanometer were used to obtain instantaneous left ventricular pressure-volume data. The dogs were subjected to 20 minutes of normothermic global myocardial ischemia, followed by 80 minutes of reperfusion under total cardiopulmonary bypass. Data were acquired during transient (10- to 12-second) periods of acute volume loading before ischemia and at 20-minute intervals during reperfusion as bypass was continued. The relationship between stroke work and end-diastolic volume (ie, preioad recruitable stroke work [PRSW]) and the end-systolic pressure-volume relationship were highly linear throughout the study (mean r = 0.954 to 0.983 for PRSW; mean r = 0.954 to 0.984 for end-systolic pressure-volume relationship). Ischemia produced changes in the PRSW; (1) the slope decreased significantly at 20 minutes and 40 minutes of reperfusion then returned to preischemic levels at 60 minutes and 80 minutes, and (2) the x-intercept increased significantly up to 60 minutes. The preload recruitable work area (the area under the linear regression line of PRSW) reflected changes in both slope and x-intercept of PRSW and was significantly decreased throughout the 80 minutes of reperfusion despite gradual recovery. The slope and the x-intercept of the endsystolic pressure-volume relationship did not change after ischemia. These results indicate that systolic dysfunction, defined as preload recruitable work area, is related to the rightward shift of the ventricular pressure-volume relationship and that systolic dysfunction may be present, even when the slopes of both PRSW and the end-systolic pressure-volume relationship have recovered.




This article has been cited by other articles:


Home page
Eur J Cardiothorac SurgHome page
J. B. Ryan, M. Hicks, J. R. Cropper, S. R. Garlick, S. H. Kesteven, M. K. Wilson, P. S. Macdonald, and M. P. Feneley
The preload recruitable stroke work relationship as a measure of left ventricular contractile dysfunction in porcine cardiac allografts
Eur J Cardiothorac Surg, November 1, 2002; 22(5): 738 - 745.
[Abstract] [Full Text] [PDF]


Home page
Eur J Cardiothorac SurgHome page
R. Krakor, M. Mochalski, T. Kuntze, R. Autschbach, P. Maddaj-Sterba, and F.-W. Mohr
Experimental effects of cardiomyoplasty on stressed normal left ventricle in sheep
Eur J Cardiothorac Surg, November 1, 1999; 16(5): 506 - 512.
[Abstract] [Full Text] [PDF]


Home page
Ann. Thorac. Surg.Home page
Y. Uozaki, A. Murakami, H. Asanoi, S. Ishizaka, and T. Misaki
Effect of Assisted Circulation on Left Ventricular Performance in a Canine Model
Ann. Thorac. Surg., March 1, 1998; 65(3): 663 - 666.
[Abstract] [Full Text] [PDF]


Home page
CirculationHome page
X. Y. Jin, D. G. Gibson, and J. R. Pepper
Early Changes in Regional and Global Left Ventricular Function After Aortic Valve Replacement : Comparison of Crystalloid, Cold Blood, and Warm Blood Cardioplegias
Circulation, November 1, 1995; 92(9): 155 - 162.
[Abstract] [Full Text]


Home page
J. Thorac. Cardiovasc. Surg.Home page
J. D. Klemperer, J. Zelano, R. E. Helm, K. Berman, K. Ojamaa, I. Klein, O. W. Isom, and K. Krieger
Triiodothyronine improves left ventricular function without oxygen wasting effects after global hypothermic ischemia
J. Thorac. Cardiovasc. Surg., March 1, 1995; 109(3): 457 - 465.
[Abstract] [Full Text]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 1994 by The Society of Thoracic Surgeons.