| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Ann Thorac Surg 1994;57:134-140
© 1994 The Society of Thoracic Surgeons
Department of Cardiovascular Surgery, National Cardiovascular Center, Osaka, Japan
Accepted for publication February 22, 1993.
* Address reprint requests to Dr Yamamoto, Department of Cardiovascular Surgery, National Cardiovascular Center, 5-7-1 Fujishirodai, Suita, Osaka, 565 Japan.
To elucidate free radical-induced lung injury associated with open heart operations for congenital heart defects, we studied 23 such patients. Maximum plasma chemiluminescence level (a marker of peroxylipids) in patients with pulmonary hypertension (n = 8) was higher than in patients with cyanotic disease (n = 8) (1,115.4 ± 189.9 versus 728.8 ± 48.3 counts; p < 0.05). There was a significant correlation between the maximum chemiluminescence level and preoperative pulmonary to systemic arterial pressure ratio (r = 0.929; p < 0.05). To investigate the effect of allogeneic leukocytes, we compared pulmonary hypertensive patients without allogeneic leukocyte transfusion during operation (n = 7) with the group with pulmonary hypertension. Both maximum chemiluminescence level during bypass (712.4 ± 24.9 versus 1,115.4 ± 189.9 counts; p < 0.05) and percent decrease in pulmonary arterial pressure after bypass (44.7% ± 6.2% versus 23.2% ± 4.5%; p < 0.05) were significantly improved, suggesting that depletion of leukocytes decreased the lung injury induced by free radical reaction.
This article has been cited by other articles:
|
|
 |
|
  A. Afrasiabi, M. Samadi, and H. Montazergaem Valved Patch for Ventricular Septal Defect With Pulmonary Arterial Hypertension Asian Cardiovasc Thorac Ann, December 1, 2006; 14(6): 501 - 504. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Komai, Y. Naito, and Y. Okamura Dextran sulfate as a leukocyte-endothelium adhesion molecule inhibitor of lung injury in pediatric open-heart surgery Perfusion, March 1, 2005; 20(2): 77 - 82. [Abstract] [PDF]
|
|
|
|
 |
|
 B. S. Allen The reoxygenation injury: Is it clinically important? J. Thorac. Cardiovasc. Surg., July 1, 2002; 124(1): 16 - 19. [Full Text] [PDF]
|
|
|
|
|
|
S J Morris Leukocyte reduction in cardiovascular surgery Perfusion, September 1, 2001; 16(5): 371 - 380. [PDF]
|
|
|
|
|
|
B. S Allen and M. N Ilbawi Hypoxia, reoxygenation and the role of systemic leukodepletion in pediatric heart surgery Perfusion, January 1, 2001; 16(1_suppl): 19 - 29. [Abstract] [PDF]
|
|
|
|
|
|
H. Komai, Y. Naito, K. Fujiwara, Y. Takagaki, Y. Noguchi, and Y. Nishimura The protective effect of a leucocyte removal filter on the lung in open-heart surgery for ventricular septal defect Perfusion, January 1, 1998; 13(1): 27 - 34. [Abstract] [PDF]
|
|
|
|
 |
|
 B. S. Allen, S. Rahman, M. N. Ilbawi, M. Kronon, K. S. Bolling, A. O. Halldorsson, and H. Feinberg Detrimental Effects of Cardiopulmonary Bypass in Cyanotic Infants: Preventing the Reoxygenation Injury Ann. Thorac. Surg., November 1, 1997; 64(5): 1381 - 1388. [Abstract] [Full Text]
|
|
|
|
|
|
K. S. Bolling, A. Halldorsson, B. S. Allen, S. Rahman, T. Wang, M. Kronon, and H. Feinberg PREVENTION OF THE HYPOXIC REOXYGENATION INJURY WITH THE USE OF A LEUKOCYTE-DEPLETING FILTER J. Thorac. Cardiovasc. Surg., June 1, 1997; 113(6): 1081 - 1090. [Abstract] [Full Text]
|
|
|
|
|
|
Q. Zhou, Y. Lai, H. Wei, R. Song, W. Yafeng, and H. Zhang Unidirectional valve patch for repair of cardiac septal defects with pulmonary hypertension Ann. Thorac. Surg., November 1, 1995; 60(5): 1245 - 1249. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| ANN THORAC SURG | ASIAN CARDIOVASC THORAC ANN | EUR J CARDIOTHORAC SURG |
| J THORAC CARDIOVASC SURG | ICVTS | ALL CTSNet JOURNALS |
