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The Annals of Thoracic Surgery, Vol 57, 134-140, Copyright © 1994 by The Society of Thoracic Surgeons
H Komai, F Yamamoto, K Tanaka, T Yagihara and Y Kawashima
To elucidate free radical-induced lung injury associated with open heart
operations for congenital heart defects, we studied 23 such patients.
Maximum plasma chemiluminescence level (a marker of peroxylipids) in
patients with pulmonary hypertension (n = 8) was higher than in patients
with cyanotic disease (n = 8) (1,115.4 +/- 189.9 versus 728.8 +/- 48.3
counts; p < 0.05). There was a significant correlation between the
maximum chemiluminescence level and preoperative pulmonary to systemic
arterial pressure ratio (r = 0.929; p < 0.05). To investigate the effect
of allogeneic leukocytes, we compared pulmonary hypertensive patients
without allogeneic leukocyte transfusion during operation (n = 7) with the
group with pulmonary hypertension. Both maximum chemiluminescence level
during bypass (712.4 +/- 24.9 versus 1,115.4 +/- 189.9 counts; p < 0.05)
and percent decrease in pulmonary arterial pressure after bypass (44.7% +/-
6.2% versus 28.2% +/- 4.5%; p < 0.05) were significantly improved,
suggesting that depletion of leukocytes decreased the lung injury induced
by free radical reaction.
ARTICLES
Prevention of lung injury during open heart operations for congenital heart defects
Department of Cardiovascular Surgery, National Cardiovascular Center, Osaka, Japan.
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