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The Annals of Thoracic Surgery, Vol 56, 1515-1517, Copyright © 1993 by The Society of Thoracic Surgeons
S Andreasson, S Gothberg, H Berggren, A Bengtsson, E Eriksson and B Risberg
Complement and fibrinolytic factors were measured in 9 infants undergoing
hemofiltration immediately after cardiopulmonary bypass in an attempt to
reduce activation of these systems. Plasma levels of C3a, C5a, and terminal
complement complexes increased during bypass by 460%, 85%, and 745%. Plasma
levels were reduced after hemofiltration in 8 of the 9 infants, and C3a and
C5a fractions were recovered in the ultrafiltrate. The observed activation
of the fibrinolytic system seemed to be unaltered by hemofiltration.
Fibrinolytic factors were not filtered. Our study shows that increased
concentrations of complement factors in the plasma after bypass in infants
may be reduced by hemofiltration.
ARTICLES
Hemofiltration modifies complement activation after extracorporeal circulation in infants
Department of Pediatric Anesthesia, East Hospital, Gothenburg, Sweden.
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