|
|
||||||||
Ann Thorac Surg 1993;56:1129-1135
© 1993 The Society of Thoracic Surgeons
Division of Cardiothoracic Surgery, Department of Surgery, Washington University School of Medicine, Barnes Hospital, St. Louis, Missouri USA
Accepted for publication January 18, 1993.
* Address reprint requests to Dr Sundaresan, Division of Cardiothoracic Surgery, Washington University School of Medicine, Suite 3107, Queeny Tower, One Barnes Hospital Plaza, St. Louis, MO 63110.
We used a bilateral lung transplant model to confirm, in primates, the results of lung preservation studies previously obtained in a canine single-lung transplant model. The donor lungs were flushed with low-potassium dextran solution and maintained semiinflated with 100% oxygen at 10 °C for a planned ischemic time of 12 hours for the lung implanted first. Of eight experiments performed, results in the 6 operative survivors form the basis of this report. After bilateral lung transplantation, animals were maintained on a ventilator for 6 hours; arterial oxygen tension, pulmonary artery pressure, and pulmonary vascular resistance were determined in the recipients at 2, 4, and 6 hours after transplantation and compared with donor values, which served as controls. Arterial oxygen tension in the recipients did not differ from the controls (p = not significant), whereas the pulmonary artery pressure and pulmonary vascular resistance showed significant elevation (p < 0.05 versus control values). After the 6 hours of assessment, the animals were exhibited and 3 survived for 48 to 72 hours with a mean arterial oxygen tension of 69 mm Hg on room air. These results demonstrate excellent lung function sfter a minimum of 12 hours of preservation in a primate model in which the animal is totally dependent on the function of transplanted lung tissue, and confirm the potential for prolonged clinical lung preservation.
This article has been cited by other articles:
![]() |
M. de Perrot, M. Liu, T. K. Waddell, and S. Keshavjee Ischemia-Reperfusion-induced Lung Injury Am. J. Respir. Crit. Care Med., February 15, 2003; 167(4): 490 - 511. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Eren, H. Esme, A. E. Balci, O. Cakir, H. Buyukbayram, M. N. Eren, L. Erdinc, and O. Satici The effect of aprotinin on ischemia-reperfusion injury in an in situ normothermic ischemic lung model Eur J Cardiothorac Surg, January 1, 2003; 23(1): 60 - 65. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Fischer, D. Hopkinson, M. Liu, and S. Keshavjee RAFFINOSE IMPROVES THE FUNCTION OF RAT PULMONARY GRAFTS STORED FOR TWENTY-FOUR HOURS IN LOW-POTASSIUM DEXTRAN SOLUTION J. Thorac. Cardiovasc. Surg., March 1, 2000; 119(3): 488 - 492. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. I. Gasparri, N. C. P. Jannis, W. J. Flameng, T. E. Lerut, and D. E. M. Van Raemdonck Ischemic preconditioning enhances donor lung preservation in the rabbit Eur J Cardiothorac Surg, December 1, 1999; 16(6): 639 - 646. [Full Text] [PDF] |
||||
![]() |
O. D. SCHNEUWLY, M. LICKER, C. M. PASTOR, A. SCHWEIZER, D. O. SLOSMAN, Y. KAPANCI, L. P. NICOD, J. ROBERT, A. SPILIOPOULOS, and D. R. MOREL Beneficial Effects of Leukocyte-depleted Blood and Low-potassium Dextran Solutions on Microvascular Permeability in Preserved Porcine Lung Am. J. Respir. Crit. Care Med., August 1, 1999; 160(2): 689 - 697. [Abstract] [Full Text] [PDF] |
||||
![]() |
F. SAKAMAKI, H. HOFFMANN, C. MULLER, H. DIENEMANN, K. MESSMER, and F. W. SCHILDBERG Reduced Lipid Peroxidation and Ischemia-Reperfusion Injury after Lung Transplantation Using Low-Potassium Dextran Solution for Lung Preservation Am. J. Respir. Crit. Care Med., October 1, 1997; 156(4): 1073 - 1081. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. C. King, O. A. R. Binns, R. C. Kanithanon, P. E. Parrino, T. B. Reece, J. D. Maliszewskyj, K. S. Shockey, C. G. Tribble, and I. L. Kron Acellular Low-Potassium Dextran Preserves Pulmonary Function After 48 Hours of Ischemia Ann. Thorac. Surg., September 1, 1997; 64(3): 795 - 800. [Abstract] [Full Text] |
||||
![]() |
O. A. R. Binns, N. F. DeLima, S. A. Buchanan, J. T. Cope, R. C. King, C. A. Marek, K. S. Shockey, C. G. Tribble, and I. L. Kron BOTH BLOOD AND CRYSTALLOID-BASED EXTRACELLULAR SOLUTIONS ARE SUPERIOR TO INTRACELLULAR SOLUTIONS FOR LUNG PRESERVATION J. Thorac. Cardiovasc. Surg., December 1, 1996; 112(6): 1515 - 1521. [Abstract] [Full Text] |
||||
![]() |
R. J. Novick, K. E. Gehman, I. S. Ali, and J. Lee Lung Preservation: The Importance of Endothelial and Alveolar Type II Cell Integrity Ann. Thorac. Surg., July 1, 1996; 62(1): 302 - 314. [Abstract] [Full Text] |
||||
![]() |
N. F. DeLima, O. A. R. Binns, S. A. Buchanan, J. T. Cope, M. C. Mauney, K. S. Shockey, C. G. Tribble, and I. L. Kron Low-Potassium Solution for Lung Preservation in the Setting of High-Flow Reperfusion Ann. Thorac. Surg., March 1, 1996; 61(3): 973 - 976. [Abstract] [Full Text] |
||||
![]() |
B. Hausen, S. Demertzis, F. Schroder, M. Beuke, and H.-J. Schafers Double-Lung Transplantation in the Rat: An Acute, Syngeneic In Situ Model Ann. Thorac. Surg., January 1, 1996; 61(1): 184 - 189. [Abstract] [Full Text] |
||||
![]() |
H. Date, S. Izumi, Y. Miyade, A. Andou, N. Shimizu, and S. Teramoto Successful canine bilateral single-lung transplantation after 21-hour lung preservation Ann. Thorac. Surg., February 1, 1995; 59(2): 336 - 341. [Abstract] [PDF] |
||||
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| ANN THORAC SURG | ASIAN CARDIOVASC THORAC ANN | EUR J CARDIOTHORAC SURG |
| J THORAC CARDIOVASC SURG | ICVTS | ALL CTSNet JOURNALS |