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The Annals of Thoracic Surgery, Vol 56, 1123-1128, Copyright © 1993 by The Society of Thoracic Surgeons
DP Taggart, M el-Fiky, R Carter, A Bowman and DJ Wheatley
Respiratory dysfunction is a well-recognized complication of cardiac
operations. To quantify its current incidence and severity after
uncomplicated cardiopulmonary bypass, serial measurements of arterial
oxygen tension (PaO2), alveolar-arterial oxygen gradient (AaO2), and
percentage pulmonary shunt fraction (%PSF) measured by a noninvasive
technique were made in 129 patients (age, 59 +/- 8 years (mean +/- standard
deviation) with good left ventricular function (left ventricular
end-diastolic pressure < 15 mm Hg) undergoing isolated coronary artery
operations (group 1) and 30 patients undergoing general surgical procedures
(group 2). Measurements were made before operation and on the first,
second, and sixth postoperative days. Seven patients in group 1 who
required prolonged ventilation were excluded from further study. In group
1, between the preoperative and second postoperative days, there was a
marked fall in PaO2 [89 +/- 11 versus 57 +/- 9 mm Hg; p < 0.001] and a
marked increase in the AaO2 gradient [18 +/- 10 versus 50 +/- 11 mm Hg; p
< 0.001)] and %PSF [3 +/- 1% versus 19 +/- 6%; p < 0.001)] with only
modest improvement by the sixth postoperative day [PaO2, 67 +/- 11 mm Hg;
AaO2, 45 +/- 11 mm Hg; %PSF, 15 +/- 4]. There were similar but less severe
changes in PaO2 and AaO2 gradients in group 2 patients, with a return to
baseline values by day 6.(ABSTRACT TRUNCATED AT 250 WORDS)
ARTICLES
Respiratory dysfunction after uncomplicated cardiopulmonary bypass
Department of Cardiac Surgery, Royal Infirmary, Glasgow, Scotland.
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