ATS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
William F. Bailey, Jr
Peter D. Buckman
John D. Mannion
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bailey, W. F.
Right arrow Articles by Mannion, J. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bailey, W. F., Jr
Right arrow Articles by Mannion, J. D.

Ann Thorac Surg 1993;56:1045-1053
© 1993 The Society of Thoracic Surgeons

Articles

Chronic stimulation enhances extramyocardial collateral blood flow after a cardiomyoplasty

William F. Bailey, Jr, MD, Michael G. Magno, PhD, Peter D. Buckman, MD, Fred DiMeo, BS, Thomas Langan, BM, AAS, Vincent T. Armenti, MD, PhD, John D. Mannion, MD*

Division of Cardiothoracic Surgery, Department of Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania USA

* Address reprint requests to Dr Mannion, Department of Surgery, Thomas Jefferson University, 607 College Building, 1025 Walnut St. Philadelpnia, PA 19107.

We have previously demonstrated that collateral blood flow can be established between skeletal muscle and myocardium in animals that have undergone a latissimus dorsi cardiomyoplasty. We have also shown that 5 minutes after the thoracodorsal nerve is electrically stimulated at 1.25 Hz, there is a sixfold increase in the collateral blood flow between the latissimus dorsi and the heart. In this experiment, we hypothesized that chronic stimulation of a latissimus dorsi cardiomyoplasty would result in a sustained increase in the latissimus-derived collateral blood flow. In 24 adult male goats, an ameroid constrictor was placed around a branch of the circumflex coronary artery, and a latissimus dorsi cardiomyoplasty was performed. After a rest period of about 1 week, the latissimus dorsi cardiomyoplasties were stimulated continuously at a 2-Hz frequency for 6 weeks. Collateral blood flow between the muscle and the heart was then measured with colored microspheres. Sixteen animals survived to the final experiment, and collaterals developed in 10. In these 10 animals, the latissimus collaterals continuously delivered 0.17 ± 0.03 mL · g–1 · min–1 (mean ± the standard error) of blood to ischemic myocardium. This flow represents 24.0% ± 3.9% of the flow measured to normal myocardium. These results demonstrate that in an animal model of coronary artery disease, chronic electrical stimulation of a latissimus dorsi cardiomyoplasty maintains an elevated level of latissimus-derived collateral blood flow to the myocardium.




This article has been cited by other articles:


Home page
 Eur J Cardiothorac SurgHome page
R. Krakor, M. Mochalski, T. Kuntze, R. Autschbach, P. Maddaj-Sterba, and F.-W. Mohr
Experimental effects of cardiomyoplasty on stressed normal left ventricle in sheep
Eur J Cardiothorac Surg, November 1, 1999; 16(5): 506 - 512.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
A. T.M Tang, J. C Jarvis, T. L Hooper, and S. Salmons
Observation and basis of improved blood flow to the distal latissimus dorsi muscle: a case for electrical stimulation prior to grafting
Cardiovasc Res, October 1, 1998; 40(1): 131 - 137.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
S. M. Carroll, C. M. A. Carroll, R. W. Stremel, S. J. Heilman, G. R. Tobin, and J. H. Barker
Vascular Delay of the Latissimus Dorsi Muscle: An Essential Component of Cardiomyoplasty
Ann. Thorac. Surg., April 1, 1997; 63(4): 1034 - 1040.
[Abstract] [Full Text]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
J. D. Mannion, V. Blood, W. Bailey, T. L. Bauer, M. G. Magno, F. DiMeo, A. Epple, and F. G. Spinale
THE EFFECT OF BASIC FIBROBLAST GROWTH FACTOR ON THE BLOOD FLOW AND MORPHOLOGIC FEATURES OF A LATISSIMUS DORSI CARDIOMYOPLASTY
J. Thorac. Cardiovasc. Surg., January 1, 1996; 111(1): 19 - 28.
[Abstract] [Full Text]

Home page
 Ann. Thorac. Surg.Home page
G. J. Magovern, F. R. Heckler, S. B. Park, I. Y. Christlieb, G. A. Liebler, J. A. Burkholder, T. D. Maher, D. H. Benckart, G. J. Magovern Jr., and R. L. Kao
Paced skeletal muscle for dynamic cardiomyoplasty
Ann. Thorac. Surg., October 1, 1995; 60(4): 1153 - 1154.
[Abstract] [PDF]

Home page
 Ann. Thorac. Surg.Home page
V. F. Blood, M. G. Magno, W. F. Bailey, Y. Shi, L. Yurgenev, F. DiMeo, R. N. Edie, and J. D. Mannion
Basic fibroblast growth factor identified in chronically stimulated cardiomyoplasties
Ann. Thorac. Surg., November 1, 1994; 58(5): 1320 - 1326.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 1993 by The Society of Thoracic Surgeons.