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Ann Thorac Surg 1993;56:990-1000
© 1993 The Society of Thoracic Surgeons
Cardiopulmonary Transplant Unit, Freeman Hospital, Newcastle-upon-Tyne, United Kingdom
* Address reprint requests to Mr Kirk, Department of Cardiac Surgery, Level 6, Directorate of Surgery, Bristol Royal Infirmary, Bristol BS2 8HW, United Kingdom.
During the past 10 years, pulmonary transplantation has emerged as a successful mode of surgical therapy for suitable patients with end-stage lung disease. Current preservation techniques of donor lungs for subsequent transplantation include core-cooling and single flush perfusion. The relative merits of these are described. These methods are essentially restricted to 6 hours of ischemia. Research in lung preservation is aimed not only at extending the safe period of ischemia but also at improving the quality of preservation. Areas of interest include the ideal composition of the perfusate, relevant pharmacologic additives, and the best conditions for preservation and harvesting. Advantages and disadvantages of the various animal models are listed in addition to the methods used in assessing the quality of preservation. There have been major advances in experimental lung preservation during the past 10 years, and we are possibly on the threshold of incorporating some of these into clinical practice. Among the most important are the adoption of colloid-based perfusates, the more widespread use of free radical scavengers, and the use of leukocyte depletion.
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Y. Shiraishi, J. R. Lee, H. Laks, P. F. Waters, A. Meneshian, A. Blitz, K. Johnson, L. Lam, and P. A. Chang L-Arginine Administration During Reperfusion Improves Pulmonary Function Ann. Thorac. Surg., December 1, 1996; 62(6): 1580 - 1586. [Abstract] [Full Text]
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Y. Naka, D. K. Roy, H. Liao, N. C. Chowdhury, R. E. Michler, M. C. Oz, and D. J. Pinsky cAMP-Mediated Vascular Protection in an Orthotopic Rat Lung Transplant Model: Insights Into the Mechanism of Action of Prostaglandin E1 to Improve Lung Preservation Circ. Res., October 1, 1996; 79(4): 773 - 783. [Abstract] [Full Text]
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E. A. Bacha, P. Herve, S. Murakami, A. Chapelier, G.-M. Mazmanian, V. de Montpreville, H. Detruit, J.-M. Libert, P. Dartevelle, and P.-S. U. L. T. Group LASTING BENEFICIAL EFFECT OF SHORT-TERM INHALED NITRIC OXIDE ON GRAFT FUNCTION AFTER LUNG TRANSPLANTATION J. Thorac. Cardiovasc. Surg., September 1, 1996; 112(3): 590 - 598. [Abstract] [Full Text]
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D. E. M. Van Raemdonck, N. C. P. Jannis, F. R. L. Rega, P. R. J. De Leyn, W. J. Flameng, and T. E. Lerut External Cooling of Warm Ischemic Rabbit Lungs After Death Ann. Thorac. Surg., August 1, 1996; 62(2): 331 - 337. [Abstract] [Full Text]
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G. Wu, F. Zhang, R. K. Salley, M. C. Robinson, and S. Chien A Systematic Study of Hypothermic Lung Preservation Solutions: Euro-Collins Solution Ann. Thorac. Surg., August 1, 1996; 62(2): 356 - 362. [Abstract] [Full Text]
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D. E. M. Van Raemdonck, N. C. P. Jannis, F. R. L. Rega, P. R. J. De Leyn, W. J. Flameng, and T. E. Lerut Delay of Adenosine Triphosphate Depletion and Hypoxanthine Formation in Rabbit Lung After Death Ann. Thorac. Surg., July 1, 1996; 62(1): 233 - 240. [Abstract] [Full Text]
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R. J. Novick, K. E. Gehman, I. S. Ali, and J. Lee Lung Preservation: The Importance of Endothelial and Alveolar Type II Cell Integrity Ann. Thorac. Surg., July 1, 1996; 62(1): 302 - 314. [Abstract] [Full Text]
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H. Date, A. N. Triantafillou, E. P. Trulock, M. S. Pohl, J. D. Cooper, and G.A. Patterson INHALED NITRIC OXIDE REDUCES HUMAN LUNG ALLOGRAFT DYSFUNCTION J. Thorac. Cardiovasc. Surg., May 1, 1996; 111(5): 913 - 919. [Abstract] [Full Text]
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B. Hausen, S. Demertzis, F. Schroder, M. Beuke, and H.-J. Schafers Double-Lung Transplantation in the Rat: An Acute, Syngeneic In Situ Model Ann. Thorac. Surg., January 1, 1996; 61(1): 184 - 189. [Abstract] [Full Text]
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G. Wu, F. Zhang, R. K. Salley, J. N. Diana, T.-P. Su, and S. Chien DELTA OPIOID EXTENDS HYPOTHERMIC PRESERVATION TIME OF THE LUNG J. Thorac. Cardiovasc. Surg., January 1, 1996; 111(1): 259 - 267. [Abstract] [Full Text]
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S. Kukkonen, L. J. Heikkila, K. Verkkala, S. P. Mattila, and H. Toivonen Prostaglanding E1 or prostacyclin in euro-collins solution fails to improve lung preservation Ann. Thorac. Surg., December 1, 1995; 60(6): 1617 - 1622. [Abstract] [PDF]
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Y. Naka, D. K. Roy, A. J. Smerling, R. E. Michler, C. R. Smith, D. M. Stern, M. C. Oz, and D. J. Pinsky INHALED NITRIC OXIDE FAILS TO CONFER THE PULMONARY PROTECTION PROVIDED BY DISTAL STIMULATION OF THE NITRIC OXIDE PATHWAY AT THE LEVEL OF CYCLIC GUANOSINE MONOPHOSPHATE J. Thorac. Cardiovasc. Surg., November 1, 1995; 110(5): 1434 - 1441. [Abstract] [Full Text]
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L. Normandin, P. Herve, C. Brink, A. R. Chapelier, P. G. Dartevelle, G.-M. Mazmanian, and Paris-Sud University Lung Transplant Group L-arginine and pentoxifylline attenuate endothelial dysfunction after lung reperfusion injury in the rabbit Ann. Thorac. Surg., September 1, 1995; 60(3): 646 - 650. [Abstract] [PDF]
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Y. Naka, N. C. Chowdhury, H. Liao, D. K. Roy, M. C. Oz, R. E. Michler, and D. J. Pinsky Enhanced Preservation of Orthotopically Transplanted Rat Lungs by Nitroglycerin but Not Hydralazine : Requirement for Graft Vascular Homeostasis Beyond Harvest Vasodilation Circ. Res., May 1, 1995; 76(5): 900 - 906. [Abstract] [Full Text]
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