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Ann Thorac Surg 1993;56:910-915
© 1993 The Society of Thoracic Surgeons

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Articles

Biophysical properties of the gelatin-resorcinformaldehyde/glutaraldehyde adhesive

Division of Thoracic and Cardiovascular Surgery and Division of Trauma Surgery, Surgical Center, Hannover Medical School, Hannover, Germany

Accepted for publication December 10, 1992.

^_* Address reprint requests to Dr Albes, Klinik für Thorax-, Herz- und Gefäβchirurgie, Medizinische Hochschule Hannover, KonstantyGutschow-Str 8, D-3000 Hannover 61, Germany.

Refixation of dissected aortic layers with gelatin-resorcinformaldehyde/glutaraldehyde (GRFG) adhesive represents a new option in the surgical treatment of aortic dissection. Because of its ability to reinforce the delicate structures of the acutely dissected aortic wall, GRFG has been used increasingly in recent years. However, the biomechanical properties of the adhesive are still unclear, and little is known regarding the optimal mode of its application. In an ex vivo study, aortic specimens from sheep were glued with warm (45 °C) adhesive under wet and dry conditions and submitted to defined degrees of compression (5 Newtons [N], 20 N). Bonded specimens were retracted to assess tensile strength and elasticity compared with two reference adhesives: cyanoacrylate gel and fibrin glue. Gelatin-resorcin-formaldehyde/glutaraldehyde and cyanoacrylate gel showed similar results at 5 N. Both provided better adhesion when applied under dry conditions (GRFG 5 N: dry, 3.5 ± 1.6 N/cm²; wet, 1.4 ± 1.0 N/cm²; cyanoacrylate gel 5 N: dry, 4.8 ± 1.8 N/cm²; wet, 3.2 ± 1.3 N/cm²). At 20 N, GRFG tensile strength was significantly increased for either condition compared with values at 5 N (GRFG 20 N: dry, 17.1 ± 4.2 N/cm²; wet, 4.8 ± 1.8 N/cm²). Fibrin glue demonstrated only weak adhesive properties even under dry conditions (fibrin glue 5 N: dry, 0.8 ± 0.3 N/cm²). Gelatin-resorcin-formaldehyde/ glutaraldehyde has good adhesive properties both in wet and dry tissue. Bonding capacity can be substantially increased when applied on dry surfaces and at increased pressures.

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