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Ann Thorac Surg 1993;56:527-538
© 1993 The Society of Thoracic Surgeons

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Articles

Management of lymphoproliferative disorders after cardiac transplantation

^a Departments of Cardiothoracic Surgery, Pathology, and Cardiology, Columbia University College of Physicians and Surgeons, New York, New York USA
^b Department of Hematologic and Lymphatic Pathology, Armed Forces Institute of Pathology, Washington, DC USA

Accepted for publication December 29, 1992.

^_* Address reprint requests to Dr Michler, Cardiac Transplant Service, Division of Cardiothoracic Surgery, Columbia University College of Physicians and Surgeons, 177 Fort Washington Ave, Med 7-435, New York, NY 10032.

We conducted a retrospective study of 516 cardiac recipients who underwent transplantation between April 1983 and April 1992, 19 of whom had development of posttransplantation lymphoproliferative disorders (PTLDs). These 19 patients presented with involvement of lung (5), gastrointestinal tract (5), disseminated disease (6), and adenoids and lymph nodes (3). B-cell proliferations ranging from an atypical hyperplasia to malignant lymphoma developed in 18 patients, and mixed cellularity Hodgkin's disease developed in 1 patient. The 19 patients with PTLD displayed a predominance of both women and cardiomyopathy as the indication for transplantation when compared with two separate control populations. No correlation was found between demographic criteria analyzed and (1) early versus late diagnosis of PTLD after transplantation, (2) the site of PTLD involvement, or (3) the histopathologic category of the PTLD lesion. Patients with gastrointestinal tract and lung PTLD involvement enjoyed an improved survival after both transplantation and PTLD diagnosis when compared with patients with PTLD involvement of all other extranodal sites. We report a high incidence of PTLD involving the lung and gastrointestinal tract in our cohort study. These sites of involvement responded better to a reduction in immunosuppression than did the other extranodal sites of involvement.

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