HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Tabayashi, K. Articles by Mohri, H. Search for Related Content PubMed PubMed Citation Articles by Tabayashi, K. Articles by Mohri, H.

The Annals of Thoracic Surgery, Vol 56, 494-498, Copyright © 1993 by The Society of Thoracic Surgeons

ARTICLES

Protection from postischemic spinal cord injury by perfusion cooling of the epidural space

K Tabayashi, K Niibori, H Konno and H Mohri
Department of Thoracic and Cardiovascular Surgery, Tohoku University School of Medicine, Miyagi, Japan.

To avoid devastating spinal cord injury during aneurysm operations, we evaluated the protective effects of epidural space perfusion cooling during occlusion of the descending thoracic aorta in a canine model. Sixteen dogs were divided into three groups: group 1 (n = 5) underwent 60 minutes of aortic occlusion without epidural space perfusion cooling; group 2 (n = 6), 60 minutes of occlusion with perfusion cooling; and group 3 (n = 5), 120 minutes of occlusion with perfusion cooling. The development of motor disturbance and its severity were examined 7 days after the procedure. In group 1, 1 dog was normal and 4 dogs showed spastic paraplegia with rigidly extended hind limbs. In group 2, 5 dogs were normal and 1 dog was unable to walk although it could move both of its hind legs slightly. In group 3, all 5 dogs were normal. Groups 2 and 3 had a significantly better neurologic outcome than group 1. Histologic examination of the spinal cord in dogs with paraplegia revealed degeneration of gray matter with macrophage infiltration. Histologic examination of the spinal cord in dogs without neurologic deficit showed enlargement of the central canal, light edema, and a small number of dark neurons. We conclude that epidural space perfusion cooling is effective in reducing the incidence of spinal cord injury after temporary occlusion of the descending thoracic aorta.

This article has been cited by other articles:

				A. Yoshitake, A. Mori, H. Shimizu, T. Ueda, N. Kabei, T. Hachiya, H. Okano, and R. Yozu Use of an epidural cooling catheter with a closed countercurrent lumen to protect against ischemic spinal cord injury in pigs. J. Thorac. Cardiovasc. Surg., November 1, 2007; 134(5): 1220 - 1226. [Abstract] [Full Text] [PDF]

				A. Mori, T. Ueda, T. Hachiya, N. Kabei, H. Okano, R. Yozu, and T. Sasaki An Epidural Cooling Catheter Protects the Spinal Cord Against Ischemic Injury in Pigs Ann. Thorac. Surg., November 1, 2005; 80(5): 1829 - 1833. [Abstract] [Full Text] [PDF]

				B. Makkad and S. Pilling Management of Thoracic Aneurysm Seminars in Cardiothoracic and Vascular Anesthesia, September 1, 2005; 9(3): 227 - 240. [Abstract] [PDF]

				G. Takahashi, M. Sakurai, K. Abe, Y. Itoyama, and K. Tabayashi MCI-186 reduces oxidative cellular damage and increases DNA repair function in the rabbit spinal cord after transient ischemia Ann. Thorac. Surg., August 1, 2004; 78(2): 602 - 607. [Abstract] [Full Text] [PDF]

				N. Motoyoshi, G. Takahashi, M. Sakurai, and K. Tabayashi Safety and efficacy of epidural cooling for regional spinal cord hypothermia during thoracoabdominal aneurysm repair Eur. J. Cardiothorac. Surg., January 1, 2004; 25(1): 139 - 141. [Abstract] [Full Text] [PDF]

				N. Motoyoshi, M. Sakurai, T. Hayashi, M. Aoki, K. Abe, Y. Itoyama, and K. Tabayashi Establishment of a local cooling model against spinal cord ischemia representing prolonged induction of heat shock protein J. Thorac. Cardiovasc. Surg., August 1, 2001; 122(2): 351 - 357. [Abstract] [Full Text] [PDF]

				K. Tabayashi and N. Motoyoshi Update: Protection from postischemic spinal cord injury by perfusion cooling of the epidural space Ann. Thorac. Surg., March 1, 2001; 71(3): 1063 - 1064. [Full Text] [PDF]