| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Annals of Thoracic Surgery, Vol 56, 474-478, Copyright © 1993 by The Society of Thoracic Surgeons
JM Redmond, AM Gillinov, RS Stuart, KJ Zehr, JA Winkelstein, A Herskowitz, DE Cameron and WA Baumgartner
Heparin coating of the extracorporeal circuit not only reduces heparin
requirements during cardiac operations but also may reduce organ injury
associated with cardiopulmonary bypass (CPB). To examine this possibility,
pulmonary injury and neutrophil adhesion molecule expression after CPB were
studied in pigs undergoing CPB with a standard extracorporeal circuit
(group S, n = 6) or a heparin-coated CPB circuit (Carmeda BioActive
Surface) (group HC, n = 6). Pigs received heparin sodium (300 U/kg
intravenously) and then underwent 90 minutes of hypothermic (28 degrees C)
CPB using membrane oxygenators, followed by 2 hours of observation. Blood
samples were obtained for determination of neutrophil number and expression
of the neutrophil adhesion molecule subunit CD18 (by immunofluorescence
flow cytometry). The CPB-associated injury was less in group HC. Two hours
after CPB, the arterial oxygen tension group was higher in group HC (597.2
+/- 31.2 versus 220.5 +/- 42.3 mm Hg; p < 0.0001), the pulmonary
vascular resistance was lower in these animals (408.6 +/- 69.4 versus
1,159.8 +/- 202.4 dyne.s.cm-5; p = 0.02), and the static compliance was
higher in group HC (66.4 +/- 5.4 versus 39.8 +/- 5.8 mL/mm Hg; p = 0.004).
After 60 minutes of CPB, both groups had similar increases in expression of
the neutrophil adhesion molecule subunit CD18 (29.4% +/- 19.5% versus 26.0%
+/- 24.4%, group S and group HC, respectively) and similar decreases in
neutrophil counts (6,056 +/- 1,285 to 2,453 +/- 979 cells/microL versus
6,010 +/- 1,748 to 3,197 +/- 1,225 cells/microL, group S and group HC,
respectively).(ABSTRACT TRUNCATED AT 250 WORDS)
ARTICLES
Heparin-coated bypass circuits reduce pulmonary injury
Department of Cardiac Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205.
This article has been cited by other articles:
|
|
 |
|
  G. S. Murphy, E. A. Hessel II, and R. C. Groom Optimal Perfusion During Cardiopulmonary Bypass: An Evidence-Based Approach Anesth. Analg., May 1, 2009; 108(5): 1394 - 1417. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. M. Carvalho, E. A Gabriel, and T. A Salerno Pulmonary Protection During Cardiac Surgery: Systematic Literature Review Asian Cardiovasc Thorac Ann, December 1, 2008; 16(6): 503 - 507. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. C. McGee Jr., P. M. McCarthy, and N. Moazami Temporary Mechanical Circulatory Support Card. Surg. Adult, January 1, 2008; 3(2008): 507 - 534. [Full Text]
|
|
|
|
|
|
D. R. Brinster, R. J. Rizzo, and R. M. Bolman III Ascending Aortic Aneurysms Card. Surg. Adult, January 1, 2008; 3(2008): 1223 - 1250. [Full Text]
|
|
|
|
 |
|
 The Society of Thoracic Surgeons Blood Conservatio, V. A. Ferraris, S. P. Ferraris, S. P. Saha, E. A. Hessel II, C. K. Haan, B. D. Royston, C. R. Bridges, R. S.D. Higgins, G. Despotis, et al. Perioperative Blood Transfusion and Blood Conservation in Cardiac Surgery: The Society of Thoracic Surgeons and The Society of Cardiovascular Anesthesiologists Clinical Practice Guideline Ann. Thorac. Surg., May 1, 2007; 83(5_Supplement): S27 - S86. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Khoshbin, A. E. Dux, H. Killer, A. W Sosnowski, R. K Firmin, and G. J Peek A comparison of radiographic signs of pulmonary inflammation during ECMO between silicon and poly-methyl pentene oxygenators Perfusion, January 1, 2007; 22(1): 15 - 21. [Abstract] [PDF]
|
|
|
|
|
|
M. E. Jessen Pro: Heparin-Coated Circuits Should be Used for Cardiopulmonary Bypass Anesth. Analg., December 1, 2006; 103(6): 1365 - 1369. [Full Text] [PDF]
|
|
|
|
|
|
Y. Yang, J. Cai, S. Wang, H. Zhang, J. Liu, Z. Xu, and Z. Su Better protection of pulmonary surfactant integrity with deep hypothermia and circulatory arrest. Ann. Thorac. Surg., July 1, 2006; 82(1): 131 - 136. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Khoshbin, C. Westrope, S. Pooboni, D. Machin, H. Killer, G. J Peek, A. W Sosnowski, and R. K Firmin Performance of polymethyl pentene oxygenators for neonatal extracorporeal membrane oxygenation: a comparison with silicone membrane oxygenators Perfusion, May 1, 2005; 20(3): 129 - 134. [Abstract] [PDF]
|
|
|
|
 |
|
 J. M. Dodd-o, L. E. Welsh, J. D. Salazar, P. L. Walinsky, E. A. Peck, J. G. Shake, D. J. Caparrelli, R. C. Ziegelstein, J. L. Zweier, W. A. Baumgartner, et al. Effect of NADPH oxidase inhibition on cardiopulmonary bypass-induced lung injury Am J Physiol Heart Circ Physiol, August 1, 2004; 287(2): H927 - H936. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. de Vroege, W. van Oeveren, J. van Klarenbosch, W. Stooker, M. A. J. M. Huybregts, C. E. Hack, L. van Barneveld, L. Eijsman, and C. R. H. Wildevuur The Impact of Heparin-Coated Cardiopulmonary Bypass Circuits on Pulmonary Function and the Release of Inflammatory Mediators Anesth. Analg., June 1, 2004; 98(6): 1586 - 1594. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Dodd-o, L. E. Welsh, J. D. Salazar, P. L. Walinsky, E. A. Peck, J. G. Shake, D. J. Caparrelli, B. T. Bethea, S. M. Cattaneo, W. A. Baumgartner, et al. Effect of bronchial artery blood flow on cardiopulmonary bypass-induced lung injury Am J Physiol Heart Circ Physiol, February 1, 2004; 286(2): H693 - H700. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Moazami and P. M. McCarthy Temporary Circulatory Support Card. Surg. Adult, January 1, 2003; 2(2003): 495 - 520. [Full Text]
|
|
|
|
|
|
C. A. Anderson, R. J. Rizzo, and L. H. Cohn Ascending Aortic Aneurysms Card. Surg. Adult, January 1, 2003; 2(2003): 1123 - 1148. [Full Text]
|
|
|
|
|
|
H. I Flom-Halvorsen, E Ovrum, F Brosstad, G Tangen, M A. Ringdal, and R Oystese Effects of two differently heparin-coated extracorporeal circuits on markers for brain and myocardial dysfunction Perfusion, September 1, 2002; 17(5): 339 - 345. [Abstract] [PDF]
|
|
|
|
 |
|
 C. S.H. Ng, S. Wan, A. P.C. Yim, and A. A. Arifi Pulmonary Dysfunction After Cardiac Surgery* Chest, April 1, 2002; 121(4): 1269 - 1277. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K McCusker, V Vijay, W DeBois, R Helm, and D Sisto MAST system: a new condensed cardiopulmonary bypass circuit for adult cardiac surgery Perfusion, December 1, 2001; 16(6): 447 - 452. [Abstract] [PDF]
|
|
|
|
 |
|
 G. E. Hill The Inflammatory Response to Cardiopulmonary Bypass-- Should It Be Treated? Seminars in Cardiothoracic and Vascular Anesthesia, September 1, 2001; 5(3): 229 - 235. [Abstract] [PDF]
|
|
|
|
 |
|
 E. Ovrum, G. Tangen, R. Oystese, M. A. L. Ringdal, and R. Istad Comparison of two heparin-coated extracorporeal circuits with reduced systemic anticoagulation in routine coronary artery bypass operations J. Thorac. Cardiovasc. Surg., February 1, 2001; 121(2): 0324 - 330. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. Gott Leukodepletion and aprotinin improve clinical outcome after extracorporeal circulation Perfusion, January 1, 2001; 16(1_suppl): 5 - 9. [Abstract] [PDF]
|
|
|
|
 |
|
 A. Belboul, C. Lofgren, C. Storm, and M. Jungbeck Heparin-coated circuits reduce occult myocardial damage during CPB: a randomized, single blind clinical trial Eur. J. Cardiothorac. Surg., May 1, 2000; 17(5): 580 - 586. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Ozawa, K. Yoshihara, N. Koyama, Y. Watanabe, N. Shiono, and Y. Takanashi Clinical efficacy of heparin-bonded bypass circuits related to cytokine responses in children Ann. Thorac. Surg., February 1, 2000; 69(2): 584 - 590. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. F Larson, D. Arzouman, L. Kleinert, V. Patula, and S. Williams Comparison of Sarns 3M heparin bonded to Duraflo II and control circuits in a porcine model: macro- and microanalysis of thrombi accumulation in circuit arterial filters Perfusion, January 1, 2000; 15(1): 13 - 20. [Abstract] [PDF]
|
|
|
|
 |
|
 K. A. Eagle, R. A. Guyton, R. Davidoff, G. A. Ewy, J. Fonger, T. J. Gardner, J. P. Gott, H. C. Herrmann, R. A. Marlow, W. C. Nugent, et al. ACC/AHA guidelines for coronary artery bypass graft surgery: A report of the American College of Cardiology/ American Heart Association task force on Practice Guidelines (Committee to revise the 1991 Guidelines for Coronary Artery Bypass Graft Surgery) J. Am. Coll. Cardiol., October 1, 1999; 34(4): 1262 - 1347. [Full Text] [PDF]
|
|
|
|
|
|
H. Kumano, S. Suehiro, K. Hattori, T. Shibata, Y. Sasaki, M. Hosono, and H. Kinoshita Coagulofibrinolysis during heparin-coated cardiopulmonary bypass with reduced heparinization Ann. Thorac. Surg., October 1, 1999; 68(4): 1252 - 1256. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Asimakopoulos, P. L.C. Smith, C. P. Ratnatunga, and K. M. Taylor Lung injury and acute respiratory distress syndrome after cardiopulmonary bypass Ann. Thorac. Surg., September 1, 1999; 68(3): 1107 - 1115. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. B. Mahoney and G. M. Lemole Transfusion after coronary artery bypass surgery: the impact of heparin-bonded circuits Eur. J. Cardiothorac. Surg., August 1, 1999; 16(2): 206 - 210. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Asimakopoulos Mechanisms of the systemic inflammatory response Perfusion, July 1, 1999; 14(4): 269 - 277. [PDF]
|
|
|
|
|
|
H. Watanabe, J.-i. Hayashi, H. Ohzeki, H. Moro, M. Sugawara, and S. Eguchi Biocompatibility of a silicone-coated polypropylene hollow fiber oxygenator in an in vitro model Ann. Thorac. Surg., May 1, 1999; 67(5): 1315 - 1319. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Picone, C. J. Lutz, C. Finck, D. Carney, L. A. Gatto, A. Paskanik, B. Searles, K. Snyder, and G. Nieman Multiple sequential insults cause post-pump syndrome Ann. Thorac. Surg., April 1, 1999; 67(4): 978 - 985. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ranucci, A. Mazzucco, R. Pessotto, G. Grillone, V. Casati, L. Porreca, R. Maugeri, M. Meli, P. Magagna, S. Cirri, et al. Heparin-coated circuits for high-risk patients: a multicenter, prospective, randomized trial Ann. Thorac. Surg., April 1, 1999; 67(4): 994 - 1000. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Lodge, P. J. Chai, C. W. Daggett, R. M. Ungerleider, and J. Jaggers METHYLPREDNISOLONE REDUCES THE INFLAMMATORY RESPONSE TO CARDIOPULMONARY BYPASS IN NEONATAL PIGLETS: TIMING OF DOSE IS IMPORTANT J. Thorac. Cardiovasc. Surg., March 1, 1999; 117(3): 515 - 522. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Asimakopoulos and K. M. Taylor Effects of cardiopulmonary bypass on leukocyte and endothelial adhesion molecules Ann. Thorac. Surg., December 1, 1998; 66(6): 2135 - 2144. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. Gott, W. A. Cooper, F. E. Schmidt Jr, W. M. Brown III, C. E. Wright, J. D. Merlino, J. D. Fortenberry, W. S. Clark, and R. A. Guyton Modifying risk for extracorporeal circulation: trial of four antiinflammatory strategies Ann. Thorac. Surg., September 1, 1998; 66(3): 747 - 754. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. S. Aldea, P. O'Gara, O. M. Shapira, P. Treanor, A. Osman, E. Patalis, C. Arkin, R. Diamond, V. Babikian, H. L. Lazar, et al. Effect of Anticoagulation Protocol on Outcome in Patients Undergoing CABG With Heparin-Bonded Cardiopulmonary Bypass Circuits Ann. Thorac. Surg., February 1, 1998; 65(2): 425 - 433. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. S Shekerdemian, A. Bush, C. Lincoln, D. F Shore, A. J Petros, and A. N Redington Cardiopulmonary interactions in healthy children and children after simple cardiac surgery: the effects of positive and negative pressure ventilation Heart, December 1, 1997; 78(6): 587 - 593. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M Ranucci, G Soro, A Frigiola, L Menicanti, A Ditta, G Candido, and S Tambalo Normothermic perfusion and lung function after cardiopulmonary bypass: effects in pulmonary risk patients Perfusion, September 1, 1997; 12(5): 309 - 315. [Abstract] [PDF]
|
|
|
|
|
|
H. L. Lazar, X. Zhang, T. Hamasaki, C. A. Memmelo, P. Treanor, S. Rivers, G. S. Aldea, S. A. Bernard, and R. J. Shemin Heparin-Bonded Circuits Decrease Myocardial Ischemic Damage: An Experimental Study Ann. Thorac. Surg., June 1, 1997; 63(6): 1701 - 1705. [Abstract] [Full Text]
|
|
|
|
|
|
O. Moen, K. Hogasen, E. Fosse, E. Dregelid, V. Brockmeier, P. Venge, M. Harboe, and T. E. Mollnes Attenuation of Changes in Leukocyte Surface Markers and Complement Activation With Heparin-Coated Cardiopulmonary Bypass Ann. Thorac. Surg., January 1, 1997; 63(1): 105 - 111. [Abstract] [Full Text]
|
|
|
|
|
|
E. Ovrum, E. A. Holen, G. Tangen, and M.-A. L. Ringdal Heparinized Cardiopulmonary Bypass and Full Heparin Dose Marginally Improve Clinical Performance Ann. Thorac. Surg., October 1, 1996; 62(4): 1128 - 1133. [Abstract] [Full Text]
|
|
|
|
|
|
G. S. Aldea, M. Doursounian, P. O'Gara, P. Treanor, O. M. Shapira, H. L. Lazar, and R. J. Shemin Heparin-Bonded Circuits With a Reduced Anticoagulation Protocol in Primary CABG: A Prospective, Randomized Study Ann. Thorac. Surg., August 1, 1996; 62(2): 410 - 418. [Abstract] [Full Text]
|
|
|
|
|
|
S. Daniel Review on the multifactorial aspects of bioincompatibility in CPB Perfusion, May 1, 1996; 11(3): 246 - 255. [Abstract] [PDF]
|
|
|
|
|
|
M. Ranucci, S. Cirri, D. Conti, A. Ditta, A. Boncilli, A. Frigiola, and L. Menicanti Beneficial Effects of Duraflo II Heparin-Coated Circuits on Postperfusion Lung Dysfunction Ann. Thorac. Surg., January 1, 1996; 61(1): 76 - 81. [Abstract] [Full Text]
|
|
|
|
|
|
E. Ovrum, T. E. Mollnes, E. Fosse, E. A. Holen, G. Tangen, M. Abdelnoor, M.-A. L. Ringdal, R. Oystese, and P. Venge COMPLEMENT AND GRANULOCYTE ACTIVATION IN TWO DIFFERENT TYPES OF HEPARINIZED EXTRACORPOREAL CIRCUITS J. Thorac. Cardiovasc. Surg., December 1, 1995; 110(6): 1623 - 1632. [Abstract] [Full Text]
|
|
|
|
|
|
P. W. Weerwind, J. G. Maessen, L. J. H. van Tits, R. K. Stad, E. J. Fransen, D. S. de Jong, and O. C. K. M. Penn INFLUENCE OF DURAFLO II HEPARIN-TREATED EXTRACORPOREAL CIRCUITS ON THE SYSTEMIC INFLAMMATORY RESPONSE IN PATIENTS HAVING CORONARY BYPASS J. Thorac. Cardiovasc. Surg., December 1, 1995; 110(6): 1633 - 1641. [Abstract] [Full Text]
|
|
|
|
|
|
D. D. Muehrcke, P. M. McCarthy, R. W. Stewart, S. Seshagiri, D. A. Ogella, R. C. Foster, and D. M. Cosgrove Complications of extracorporeal life support systems using heparin-bound surfaces: The risk of intracardiac clot formation J. Thorac. Cardiovasc. Surg., September 1, 1995; 110(3): 843 - 851. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| ANN THORAC SURG | ASIAN CARDIOVASC THORAC ANN | EUR J CARDIOTHORAC SURG |
| J THORAC CARDIOVASC SURG | ICVTS | ALL CTSNet JOURNALS |
