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Ann Thorac Surg 1993;56:462-468
© 1993 The Society of Thoracic Surgeons

Articles

St. Jude prosthesis for aortic and mitral valve replacement: A ten-year experience

John M. Kratz, MD*, Fred A. Crawford, MD, Robert M. Sade, MD, Arthur J. Crumbley, MD, Martha R. Stroud, MS

Division of Cardiothoracic Surgery, Medical University of South Carolina, Charleston, South Carolina USA

* Address correspondence to Dr Kratz, Division of Cardiothoracic Surgery, Medical University of South Carolina, 171 Ashley Ave, Rm 409, CSB, Charleston, SC 29425.

From January 1, 1979 through December 1990, 456 adult patients underwent isolated aortic (AVR) (254) or mitral (MVR) (202) valve replacement with the St. Jude prosthesis at the Medical University of South Carolina. Age ranged from 21 to 84 years (mean: 54 ± 15 years for AVR; 51 ± 13 years for MVR). Male sex predominated in the AVR group (66%) and female sex in the MVR group (64%). Ninety-two patients (20%) had associated coronary artery bypass grafting (AVR, 25%; MVR, 14%). There were 17 deaths (3.7%) occurring during the same hospitalization or within 30 days (AVR, 10/254 [3.9%]; MVR, 7/202 [3.5%]). Follow-up is 94.5% complete and ranges from 1.0 to 131 months (mean, 55 ± 37 months; total, 2,073 patient-years). In the AVR group, 53 late deaths have occurred and actuarial survival is 80% ± 3% at 5 years and 47% ± 9% at 10 years. Twenty-one patients have sustained thromboembolic episodes (1.8%/patient-year), and the probability of remaining free of thrombo-embolism at 10 years is 67% ± 13%. The mean improvement in New York Heart Association functional class from preoperative to postoperative is 3.1 ± 0.76 to 1.6 ±0.84 p < 0.0001). In the MVR group, there have been 41 late deaths, and the actuarial survival was 80% ± 3% at 5 years and 63% ± 5% at 10 years. Twenty-eight patients have sustained thromboembolic complications (2.9%/ patient-year), and the probability of remaining free of thromboembolism at 10 years is 77% ± 5% The mean improvement in New York Heart Association functional class is from 3.4 ± 0.63 preoperatively to 1.8 ± 0.91 postoperatively (p < 0.0001). There were no mechanical failures, but 19 patients underwent 22 replacements of a previously implanted St. Jude prosthesis for endocarditis (14), paravalvular leak (4), thrombosis (2), and hemolysis (2). This intermediate-term follow-up confirms our earlier impression that in adults in whom valve repair is not possible, the St. Jude valve is a reliable, durable prosthesis with excellent hemodynamic function and a low rate of thrombosis/thromboembolism.




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