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The Annals of Thoracic Surgery, Vol 55, 1175-1179, Copyright © 1993 by The Society of Thoracic Surgeons
LC John, GM Rees and IB Kovacs
The direct effect of aprotinin on in vitro platelet function was assessed
by hemostatometry (n = 10). No significant enhancement was demonstrated.
However, aprotinin reduced platelet inhibition secondary to heparin.
Hemostatometry demonstrated a significant preservation of in vitro platelet
function (n = 25) (p = 0.04), which was particularly marked (p = 0.003) in
the subgroup (n = 7) demonstrating a severe inhibition of platelet function
with heparin. Aprotinin significantly reduced the binding of
tritium-labeled heparin to both nonactivated (n = 25) (p = 0.004) and
activated platelets (n = 25) (p < 0.0001). We conclude that interference
with heparin-induced inhibition of platelet function by aprotinin may be
one of its hemostatic actions in cardiac surgery. This effect is probably
secondary to aprotinin reducing binding of heparin to platelets.
ARTICLES
Reduction of heparin binding to and inhibition of platelets by aprotinin
Department of Cardiothoracic Surgery, St. Bartholomew's Hospital, London, England.
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