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The Annals of Thoracic Surgery, Vol 55, 1131-1137, Copyright © 1993 by The Society of Thoracic Surgeons
S Demertzis, J Wippermann, J Schaper, T Wahlers, HJ Schafers, I Wagenbreth, B Hausen and A Haverich
Prolongation of the safe period of ischemia of the heart is an efficient
way to overcome donor organ shortage, as demonstrated in renal and hepatic
transplantation. We present the results of a prospective, randomized study
comparing preservation with University of Wisconsin solution (UWS) versus
St. Thomas' Hospital solution (STS) in clinical heart transplantation. A
total of 39 patients were enrolled in the study (n = 20 for UWS and n = 19
for STS). Hemodynamic, electron microscopic, and biochemical evaluation did
not reveal any significant differences in postoperative myocardial
performance. Only the number of intraoperative defibrillations (0.82 for
UWS versus 1.7 for STS) and the rhythm stability after reperfusion (13/20
UWS hearts versus 6/19 STS hearts in sinus rhythm) were significantly
different. Heart preservation with UWS and STS appears to be of comparable
efficacy at mean ischemic times of less than 4 hours.
ARTICLES
University of Wisconsin versus St. Thomas' Hospital solution for human donor heart preservation
Division of Thoracic and Cardiovascular Surgery, Hannover Medical School, Germany.
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